Could a gut supplement boost brain health in schizophrenia?
NCT ID NCT05527210
First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 37 times
Summary
This study tests whether a prebiotic supplement (Prebiotin®) can reduce inflammation and improve thinking in people with schizophrenia or schizoaffective disorder. Sixty adults aged 18-60 who are stable on antipsychotics will take the prebiotic or a placebo for 12 weeks. Researchers will measure changes in blood butyrate levels, cognitive test scores, and side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Maryland Psyciatric Research Center
RECRUITINGCatonsville, Maryland, 21228, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prebiotin® (a prebiotic dietary supplement)
What this could lead to
If it works, this could point toward a simple, safe way to improve thinking and reduce inflammation in people with schizophrenia.
What could go wrong
This is a small, early-stage trial with only 60 participants. The prebiotic may not change inflammation or cognition, and results may not apply to everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.