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Anti-Inflammatory diet tested as long COVID fatigue fix for seniors

NCT ID NCT05977179

Symptom relief Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether following a healthy US-style diet rich in anti-inflammatory foods can reduce fatigue and improve muscle and physical function in adults aged 50 and older with long COVID. Over 16 weeks, participants are randomly assigned to either receive personalized diet plans and weekly sessions or attend general health sessions. The goal is to see if a whole-diet approach can ease lingering symptoms after COVID-19.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
healthy US-style anti-inflammatory diet
What this could lead to
If it works, this could point toward a simple dietary approach to ease fatigue and improve physical function in older adults with long COVID.
What could go wrong
This is a small early-stage trial with only 56 participants, so results may not apply to everyone. Diet changes can be hard to stick with, and the effect may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 94 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age of 50 years or older 2. No known active infectious disease (COVID-19 or other). 3. Participant diagnosed with long-COVID/ post- acute COVID-19 syndrome (PACS) /ICD-10-CM codes U09.9 4. Moderate/severe fatigue Brief Fatigue Inventory (BFI)≥4 5. Poor diet quality assessed by the short Healthy Eating Index (HEI)\<70 Exclusion Criteria: 1. Participants with a home oxygen requirement or requiring chronic ventilator support 2. Participants diagnosed with diabetes who do not have a recent HbA1c level or with HbA1c \> 9% 3. Participants diagnosed with Congestive Heart Failure (CHF New York Heart Association) \> class 2 4. Participants with dietary restrictions due to medication use that affects blood clotting, such as Warfarin or other reasons. 5. Evidence of any condition as determined by a physician or the study team that would lead to an increased risk of illness due to any aspect of proposed testing and interventions, or introduce unanticipated confounding of study results. 6. Participants diagnosed with uncontrolled hypertension that will be defined as: 1. Systolic blood pressure consistently equal to or higher than 190 mmHg. 2. Diastolic blood pressure consistently equal to or higher than 110 mmHg. 3. Participants with a recent history of hypertensive crisis (severe elevation in blood pressure requiring immediate medical intervention), regardless of current blood pressure levels. 7. Participants with diet restrictions or allergies that can affect adherence to the diet, such as allergy to fish or shellfish. 8. Participation in another trial in which active intervention is being received. 9. Participants with active drug or alcohol use/dependence that would interfere with adherence to the study. 10. Participants scheduled for surgical procedures within the next 6 months. 11. Participants diagnosed with active cancer. 12. Participants diagnosed with liver diseases. 13. Participants diagnosed with kidney-related conditions, including Chronic Kidney Disease (CKD) \> stage 3. 14. Below the age of 50 years.

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Conditions

The condition(s) this trial relates to.

Fatigue long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fatigue Post-acute COVID-19 syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Maryland, Baltimore

    RECRUITING

    Baltimore, Maryland, 21201, United States

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