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Sound waves aim to stop hand cramps in musicians and writers

NCT ID NCT06367608

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests whether MRI-guided focused ultrasound can safely treat task-specific focal hand dystonia, a condition that causes hand cramps during activities like writing or playing an instrument. Ten adults who have not improved with standard treatments will receive a precise ultrasound procedure to a small brain area. Researchers will track side effects and measure changes in hand function and quality of life over six months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Clinical diagnosis of moderate to severe TSFD with impact in their daily function or occupation function 2. Patients who failed to response or had unsatisfactory response to the first treatment, such as Botulinum toxin treatment or DBS or refuse these alternative options 3. Age greater than 21 and less than 75 years 4. Subjects who are able and willing to give consent and able to attend all study visits, 5. Documented chronic, symptoms for more than 6 months duration 6. Pallidotomy is feasible based on evaluation of imaging studies 7. Patient able to communicate sensations during the ExAblate TcMRgFUS treatment 8. Two members of the medical team have agreed upon inclusion and exclusion criteria Exclusion Criteria: 1. Patient with contraindications to MRI such as severe claustrophobia and metallic implants incompatible with MRI. 2. Presence of generalized dystonia or involvement of two or more contiguous body regions (such as Arm along with neck) 3. Severe psychiatric disorder such as uncontrolled depression, anxiety, bipolar disorder, prior attempt at suicide or suicide ideation in preceding 12 months 4. Life expectancy less than 12 months 5. Anticoagulant or antiplatelet medications as well as underlying coagulopathy 6. Pregnant ladies or women of childbearing age who are sexually active and not using contraception 7. Inability to provide informed consent, for example due to underlying cognitive impairment or aphasia 8. Presence of intracranial mass or an acute intracranial abnormality 9. Subjects with unstable cardiac status such as unstable angina pectoris, documented myocardial infarction within 6 months of protocol entry or ejection fraction less than 40 10. Subjects exhibiting any behavior(s) consistent with ethanol or substance abuse as defined by the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders(DSM-IV) 11. Severe hypertension (diastolic blood pressure \> 100 on medication or persistently elevated systolic blood pressure\>140 mmHg despite adequate antihypertensive medications) 12. History of intracranial hemorrhage, traumatic brain injury or thalamic stroke. 13. Cerebrovascular disease (multiple cerebrovascular accident's (CVA) or CVA within 6 months) 14. Subjects with life-threatening systemic disease that include and not limited to the following will be excluded from the study participation: HIV, Liver Failure, blood dyscrasias, etc. 15. Subjects with a history of seizures within the past year 16. Individuals who are not able or willing to tolerate the required prolonged stationary supine position during treatment (can be up to 4 hours of total table time.) \-

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Maryland Medical Center

    RECRUITING

    Baltimore, Maryland, 21201, United States