University Of Maryland, Baltimore

This study tested how well the drug primaquine prevents the return of P. vivax malaria in 160 adults. Participants had uncomplicated malaria and normal G6PD levels. The goal was to see if a short treatment could stop relapses, aiming for a complete cure.

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This early-stage trial tested a combination of two drugs, pegcrisantaspase and venetoclax, in 27 adults whose acute myeloid leukemia had come back or not responded to standard treatments. The main goal was to find safe doses and check for side effects. Researchers also looked at …

This study tested a simple change in how lab results for respiratory cultures are reported to doctors. For patients on ventilators who did not meet clinical criteria for pneumonia, the lab report noted that the bacteria found might just be harmless colonization. The goal was to s…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study tested a counseling program adapted for young adults (ages 13-35) who have early psychosis and use cannabis. The program aimed to reduce cannabis use and help manage psychosis symptoms. Seventeen participants completed the pilot, which focused on education and harm red…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This pilot study tested whether using smart insulin pens together with continuous glucose monitors (CGMs) can improve blood sugar control in adults with type 2 diabetes. Thirty participants with poorly controlled diabetes used these devices for six months. The goal was to see if …

This study tested whether H.P. Acthar Gel can improve symptoms and quality of life in people with CNS sarcoidosis, a rare condition where inflammation affects the brain and spinal cord. Four adults with the disease received the gel to see if it could control disease activity and …

This pilot study looked at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder could help them cut down on smoking. The 36 participants were not trying to quit smoking at the start. Researchers measured how many people switched to …

This study looked at whether special hip muscle exercises can help older adults improve their balance and prevent falls. Researchers tested 97 people aged 65 and older who were generally healthy and living independently. They compared high-velocity hip power training to conventio…

This study tested whether luteolin, a natural supplement found in foods like celery and chamomile tea, can improve symptoms in people with schizophrenia or schizoaffective disorder. 85 clinically stable adults took either luteolin or a placebo for 12 weeks while continuing their …

This study tested a home-based telerehabilitation system for veterans with multiple sclerosis. The system provided exercise instructions and tracked daily logs to help improve balance and mobility. The goal was to see if this approach was feasible and acceptable to patients.

This study tested whether combining robotic arm training with functional electrical stimulation (FES) helps people with chronic stroke improve arm movement more than robotic training alone. 24 adults who had a stroke at least 6 months earlier participated. The goal was to see if …

This study looked at whether gentle touch and massage therapy can help very premature babies in the NICU. 32 babies were split into two groups: one received massage therapy plus standard care, the other received standard care alone. Researchers tracked how long each baby stayed i…

This study looked at whether adding the antidepressant duloxetine to a walking program helps older adults with both knee osteoarthritis and depression. All 43 participants received the same combination treatment. The goal was to see if the approach is feasible and if it reduces p…

This study looked at whether brief Christian prayer, given in person or virtually, can lower pain and anxiety in adults visiting a family medicine clinic. 180 participants with moderate or higher pain or anxiety were randomly assigned to receive prayer or listen to 5 minutes of r…

This study tested whether virtual reality (VR) exercises can improve memory and thinking in adults aged 65 and older who had a mild traumatic brain injury. Thirty participants used VR at home for six weeks. The goal was to see if VR could help with attention, memory, and visual s…

This study looked at whether suvorexant, an FDA-approved sleep medication, can improve daytime symptoms like fatigue, mood, and thinking in older adults with insomnia. Forty participants took either the drug or a placebo and used a smartphone app to report how they felt throughou…

This study tested a smartphone app called POSTHOC that helps cancer survivors manage symptoms and track healthy behaviors after finishing treatment. Fifty-one adults who recently completed cancer therapy used the app or received standard care for 12 weeks. The goal was to see if …

This completed early-phase study looked at how epinephrine (adrenaline) affects blood vessel function and clotting in 32 healthy adults. Researchers gave participants epinephrine or a placebo and measured changes in artery dilation. The goal was to better understand why people wi…

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 adults with schizophrenia or related disorders. Participants took tryptophan to raise a brain chemical called kynurenic acid, then had cognitive tests and brain scans. T…

This early-phase study tested whether the antidepressant fluoxetine (Prozac) can improve the body's ability to respond to low blood sugar during exercise in people with type 1 diabetes. It included 64 adults (32 with type 1 diabetes and 32 healthy controls) aged 18-45. Researcher…

This study tested whether a 6-week breathing muscle training program is feasible for typically developing children aged 6-12. Researchers measured how well children completed the training and how it affected their breathing during exercise. The goal was to understand the diaphrag…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at whether a 6-week breathing muscle training program is possible for childhood cancer survivors and how it affects their breathing during exercise. Seven survivors who finished cancer treatment at least a year ago took part. The goal was to see if they could st…

This study looked at how watching someone else experience pain relief can actually reduce your own pain. Researchers used brain scans to see which parts of the brain are involved in this effect. 211 healthy adults took part, and the goal was to understand the brain mechanisms beh…

This study looked at whether two specially made estrogen creams deliver similar amounts of the hormone into the blood. Eight postmenopausal women aged 45 to 65 used both creams, and researchers measured hormone levels after single and repeated use. The goal was to check quality, …

This study looked at how age and body fat affect inflammation in 100 veterans. Researchers wanted to see if losing a moderate amount of weight and increasing aerobic exercise could lower inflammation. Participants were overweight or obese but otherwise stable on their medical tre…

This study tested a wellness program for long-term care workers to see if it could reduce stress and improve heart health. About 159 staff and residents took part. The program focused on healthy habits like diet, exercise, and stress management, and also looked at whether staff r…

This study looked at how a non-invasive brain stimulation technique called TMS affects brain activity in people with schizophrenia. Ten participants received both real and fake TMS in separate sessions. Researchers measured brain connections and electrical signals before and afte…