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Veterans study: shedding pounds and moving more may cool inflammation

NCT ID NCT00667030

Knowledge-focused Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 100 overweight veterans to see if losing weight and doing aerobic exercise could lower inflammation linked to aging. Researchers measured inflammatory chemicals from fat tissue and checked fitness, body composition, and blood sugar. The goal was to understand how lifestyle changes might improve health in older adults.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could show that moderate weight loss and exercise reduce inflammation, pointing toward lifestyle changes that improve health in older adults.
What could go wrong
This is an observational study with no treatment being tested, so it won't prove cause and effect. Results may not apply to everyone, and lifestyle changes can be hard to maintain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Jul 2005

Finished

Sep 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI 20-40 kg/m2 * Waist 80-120cm (men), 70-110cm (women) * Stable Medical Regimen \> or = 30 days * All women over the age of 50 must be postmenopausal for at least 1 year, have serum FSH \>30 mIU/ml, and agree to remain off hormone replacement therapy for the duration of the study Exclusion Criteria: * Pregnancy or Nursing Mothers * Cigarette Smoking * Diabetes on Medication or Fasting Glucose \>126 mg/dl * Poorly controlled hypertension requiring \>3 drugs or beta blockers * Hyperlipidemia with TG\>400mg/dl, LDL\>190mg/dl or on Lipitor or Crestor * Other medications affecting glucose, lipid or cytokine levels * Thyroid Disease * Weight gain/loss \>5kg in preceding 3 months * Alcohol \>3oz/day * Caffeine \>120 oz/day * Chronic liver, renal or hematological disease * Lung disease requiring oxygen * Active cancer on radiation or chemotherapy treatment * HIV (+) or other disease prone to malnutrition * Sickle cell anemia * Active psychosis or dementia * Chronic untreated depression * Hemiparetic Stroke * Coronary Artery or cerebrovascular disease precluding exercise * Implantable defibrillator * Other medical condition precluding exercise testing or participation in exercise and weight loss programs, as per medical judgement of study team

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease metabolic disease Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Exercise Inflammation Metabolism

Contacts and locations

Locations

  • University of Maryland; Baltimore VA Medical Center

    Baltimore, Maryland, 21044, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.