AGING

This study looks at whether a combination of physical exercise and a thermogenic nutritional supplement can help improve body composition, metabolism, and overall health in adults aged 50-65 who are overweight but not obese. Participants must have at least two signs of metabolic …

This study tests two drugs, sirolimus and everolimus, given once a week to see if they can safely target the basic biology of aging. Healthy adults aged 55 to 89 take one of three doses for 6 weeks. The goal is to find a dose that is safe and could help control the aging process.

This study tests whether a daily supplement called nicotinamide mononucleotide (NMN) can reduce biological age in healthy adults aged 40-70. Participants will take NMN or a placebo for 12 months, and researchers will measure aging using blood tests and other markers. The goal is …

This study looks at whether adding a special care program (GRACE) to regular annual check-ups can improve health and reduce hospital stays for older adults with multiple health issues. About 6,000 people aged 65 and older with complex needs will take part. The goal is to see if t…

This study tests a daily oral supplement designed to boost nitric oxide, a natural chemical that helps blood vessels relax and stay clot-free. As we age, blood vessels can become less efficient, raising the risk of heart disease. The supplement aims to lower levels of PAI-1, a bl…

This study looks at whether taking a natural supplement and doing moderate exercise twice a week can improve immune function and reduce inflammation in adults aged 65 and older. Sixty participants will take either the supplement or a placebo for six months while following a super…

This study looks at how binge drinking affects blood pressure, blood vessel health, and nerve activity in people aged 50-64. It then tests whether 8 weeks of aerobic exercise can improve these measures. The goal is to find a non-drug way to reduce heart risks in this group.

This study tests whether short, controlled low-oxygen breathing sessions (intermittent hypoxia) can improve blood flow to the brain and thinking skills in adults aged 60-85 with type 2 diabetes. Researchers will compare the breathing training to a placebo in 80 participants. The …

This study tests whether a traditional Chinese medicine (TCM) formula can improve muscle strength and bone health in older adults who are starting to become frail. 90 people aged 65 and older who are pre-frail will be randomly assigned to take either the TCM formula or a nutritio…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older with high blood pressure. It compares this quick exercise to the standard…

This study tests whether a smartphone app with reminders and education can help older adults (60+) with mild memory problems stick to their blood pressure medication routine. About 100 participants will use the app or receive standard education for 16 weeks. The goal is to see if…

This study tests whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve health in people aged 70 to 85. Researchers believe that restoring gut bacteria may help with aging-related issues like memory, physical function, and inflammation. T…

This study is testing whether a 12-week program combining a special nutritional supplement (with synbiotics) and supervised exercise can improve muscle strength, gut health, immune function, and thinking skills in 40 adults aged 50-80 who are showing early signs of frailty. The g…

This study tests whether a special food containing probiotics and prebiotics can help slow or reverse bone loss in older women. About 220 women aged 60 and older will take either the active food or a placebo for 18 months. The main goal is to see if it improves spine bone density…

This study tests whether a ketone supplement can reduce the harmful effects of a high-salt diet in adults aged 60-85. Researchers will measure changes in blood pressure, blood vessel function, and kidney health. The goal is to find a simple way to protect older adults from salt-r…

This study tests two ways to help people with peripheral artery disease (PAD) walk farther and with less pain. It compares supervised treadmill exercise versus home walking, with or without nitrate-rich beetroot juice. The goal is to find a more convenient and effective treatment…

This study tests whether the drug sirolimus can slow down aging in adults aged 65 to 80. Researchers will measure changes in aging-related blood markers and physical abilities like walking speed over one year. The goal is to see if sirolimus can reduce age-related decline and pre…

This study tests whether the weight-loss drug tirzepatide can slow biological aging in 90 adults aged 55-70. Participants will receive weekly injections or no drug for 24 weeks, then be followed for 12 more weeks. The focus is on changes in DNA-based aging markers, not weight los…

This study looks at whether a type of dietary fiber (soluble corn fiber) can help older men absorb more calcium and improve bone health. Researchers think fiber changes gut bacteria, which may boost calcium absorption. Thirty male Veterans aged 60 and older will take part in this…

This study tests whether a daily pill called empagliflozin (a type of SGLT2 inhibitor) can reduce stiffening of arteries that happens with age. The trial will include 80 healthy adults aged 60-80 who have some artery stiffness but no diabetes. Participants will take the drug or a…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during a hospital stay. One program uses hospital staff, while the other also involves family members or care partners. The goal is to see which approach works better to reduce confus…

This study tests a new program called Cafe Move that aims to prevent age-related physical frailty. Researchers will enroll 36 older adults who live independently and can walk without help. The program is designed to be easy to access and helps people take charge of their own phys…

This study looks at whether different types of exercise can improve brain health and reduce the risk of Alzheimer's disease in older African Americans. Researchers will compare a cardio-dance fitness program to a strength, flexibility, and balance program over six months. Partici…

This study looks at whether combining physical exercise with cognitive training (like brain games) can improve memory, thinking speed, and overall brain health in people aged 50 and older with stable chronic heart failure. Researchers will also check if the benefits differ betwee…

This study tests two injectable products, INNEA and INNEA AQUA, to see how well they reduce wrinkles on the cheeks and décolletage (upper chest). About 55 women aged 35 to 65 with at least mild wrinkles will receive up to three injections. Doctors will check wrinkle improvement o…

This study tests whether a program of exercise, nutrition advice, and geriatric care before surgery can help adults aged 65+ with breast cancer maintain physical function and reduce complications. About 90 participants will follow the 8-week program, and researchers will track ch…

This study tests a personalized digital meditation program (MediTrain) in 90 older adults aged 60-85 with mild cognitive impairment (MCI). The goal is to see if it improves sleep quality, reduces stress, and boosts cognitive abilities compared to healthy older adults. Participant…

This study tests a supplement called EGA® to see if it helps healthy adults aged 60 to 80 exercise longer. Participants will take the supplement or a placebo and measure how long they can cycle before getting tired. The goal is to improve exercise tolerance and understand effects…

This study tests how well different cooling methods (like fans or cold water) reduce heart strain in healthy adults aged 65 and older during simulated heat waves. Researchers will measure body temperature and heart function to find the best way to keep seniors safe in extreme hea…

This study tests whether a daily vitamin B3 supplement called Nicotinamide Riboside (NR) can improve brain health and memory in healthy older adults aged 60 to 85. Researchers will measure changes in brain blood flow and activity using non-invasive techniques like brain scans and…

This study tests whether a special video-based game can help adults aged 60 and older improve their balance, thinking skills, and self-confidence. Participants will play the game twice a week for six weeks. Researchers will compare their results to a group that does not play the …

This study tests a chatbot that guides people through telling their life story to improve emotional well-being. It includes healthy adults, people with mental health conditions in residential care, and older adults aged 65+. The chatbot is not a treatment but a tool to support em…

This study tests three different exercise programs—core stabilization, amplitude-based movements, and a combination of both—in healthy adults aged 65 and older. The goal is to see which program best improves dynamic balance and reduces fall risk. Participants will be assessed on …

This study looks at whether adding mental tasks (like memory games) to water aerobics can improve thinking skills in older women who don't currently exercise. About 98 women aged 60-75 will be placed into one of three groups: water aerobics with brain games, water aerobics alone,…

This study looks at whether a 16-week program combining mindfulness meditation and Nordic walking-pole exercise can improve physical function, mood, and sleep in adults aged 55 and older. About 1,500 participants will take part from community settings. The goal is to see if this …

After total knee replacement, many patients experience lasting leg weakness. This study tests whether adding neuromuscular electrical stimulation (NMES) to standard physical therapy can improve strength and mobility. Researchers will enroll 3,250 patients across two large healthc…

This study tests whether a daily ketone supplement can help adults aged 65 and older who are starting to lose strength and mobility. Over 20 weeks, 180 participants will either take a ketone drink or a placebo and be monitored for changes in physical function, immune health, and …

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood tests at the start and end. The goal is to see if…

This study tests whether a natural supplement combined with a supervised exercise program can improve mood, sleep, memory, and physical function in women going through perimenopause. Researchers will compare the supplement to a placebo while all participants exercise three times …

This study tests whether two natural substances, urolithin A and fisetin, can improve sleep quality and reduce signs of aging in adults aged 30 to 75. Eighty participants will take daily capsules for 12 weeks and undergo sleep tests, blood work, and other health checks. The goal …

This study tests whether a technology-assisted block training program can improve cognitive function, hand dexterity, and grip strength in community-dwelling older adults aged 65 and older. Participants will engage in block-building activities with technological support, and rese…

This study tests a device called Walkasins that provides gentle vibrations to the legs to replace lost foot sensation. Researchers want to see if it helps 30 older adults (ages 65-95) with foot numbness walk more automatically and with less mental effort. Participants will walk w…

This early-stage study tests whether fisetin, a compound found in fruits, can reduce aging-related cells in the body and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will take fisetin or a placebo for several months, and researc…

This study looks at whether a one-year, home-based exercise program can help older adults (60+) who are undergoing cancer treatment. Participants will be randomly assigned to either the exercise program or usual care. Researchers will measure walking speed, balance, muscle streng…

This study is testing whether nicotine gum can reverse age-related hearing problems. Researchers will give nicotine gum to healthy adults aged 18 to 85 and measure their hearing and brain responses. The goal is to see if nicotine can improve how the brain processes sound, which c…

This study is testing whether a precise vibration system can improve muscle strength, coordination, and movement, and reduce pain in older adults and stroke survivors. Researchers will recruit 80 participants to try the vibration exercises and measure changes in strength, balance…

This study tests whether a topical product can improve skin hydration and reduce wrinkles in adults aged 45 to 65. Researchers will measure changes in skin moisture and wrinkle depth after 2 and 8 weeks of use. The study involves 30 healthy volunteers with visible facial wrinkles…

This study tests a program called SickleFit that combines exercise and nutrition coaching for adults aged 35 and older with sickle cell disease. The goal is to see if the program is safe, doable, and liked by participants. About 40 people will take part, with some getting the pro…

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults (60+) who have had lasting cognitive symptoms after COVID-19. 75 participants will either use the brain-training program or do other computer activities for about 6 week…

This study tests three types of leg exercises (leg press, vibration, or mixed) to see which best improves blood flow and walking ability in older adults with poor circulation or chronic wounds. 425 participants will exercise 3 times a week for 12 weeks. The goal is to find a safe…

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study tests whether doing exercises that challenge both the mind and body at the same time—like walking while counting backwards—can improve balance, reduce falls, and enhance sleep in older adults. The exercises are done at home through video calls, making them easy to acce…

This study tests whether a special type of tai ji quan that combines physical movement with mental tasks can reduce falls in older adults with mild cognitive impairment (MCI). Researchers will enroll 336 people aged 65 and older who have memory complaints and a history of falls o…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study tests whether shining a specific red light on the legs each day before a walking workout can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to narrowed arteries. The trial will involve 32 adults aged 50 and…

This study explores whether taking a daily polyphenol supplement (natural compounds found in plants) alongside a 12-week exercise program can help older adults build strength and physical function better than exercise alone. Researchers will recruit 40 people over 60 to test if t…

This study tests a small, TENS-like device that gives mild electrical stimulation to see if it can improve balance and walking in older adults. About 120 people aged 60 and older will do tasks like walking for 6 minutes and standing on foam while wearing the device. The goal is t…

This study looks at whether whole body vibration therapy, when added to usual care, can improve muscle mass, strength, and function in older adults. Forty people aged 65 and older with mild frailty will be randomly assigned to receive vibration therapy plus usual care or usual ca…

This study looks at how well a blood test can predict a person's fitness level, measured by VO₂max. Researchers will collect blood samples and fitness data from 250 healthy adults. The goal is to see if certain molecules in the blood can accurately estimate how fit someone is, an…

This study is testing a digital meditation program to see if it can improve thinking and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. The goal is to find the best amount of meditation needed to help with mem…

This study looks at how two drugs, sirolimus and everolimus, work in the bodies of healthy adults aged 65 and older. The goal is to measure drug levels and their effects on aging-related markers. 60 participants will take the drugs for a short time and undergo tests. The results …

This study aims to create a large, diverse group of 1,000 older adults (age 60+) to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will have yearly check-ups including memory tests, brain s…

This study looks at how a single dose of psilocybin, the active ingredient in magic mushrooms, might change brain structure and activity in healthy older adults. Forty volunteers aged 60 to 85 will receive a dose ranging from micro to moderate-high and undergo MRI scans. The goal…

This study looks at whether common heart medications called beta blockers (propranolol and metoprolol) cause older adults to get hotter during extreme heat exposure. Researchers will measure body temperature and sweat rate in 22 healthy adults aged 65 and older over 3 hours in a …

This study looks at whether taking low-frequency ultrasound baths can help people age more healthily. Twenty volunteers aged 70 and older will either get real ultrasound baths or plain baths (no ultrasound) three times a week for 8 weeks. Researchers will check changes in muscle …

This study tests whether guided mental imagery can help mid-life adults stay motivated to exercise regularly. Researchers will track how often 160 participants attend workouts and measure changes in brain activity using MRI. The goal is to find a simple way to improve long-term e…

This study is observing 650 adults to understand how obesity and aging interact. Researchers will measure blood markers and body fat to see if obesity makes people age faster biologically. The goal is to lay groundwork for future treatments or lifestyle changes that could slow ag…

This study tests a special toolkit designed to help primary care doctors have better conversations about future care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolkit leads…

This study looks at why older adults respond differently to the same exercise program. Researchers will measure fitness, muscle strength, and balance in 250 healthy adults aged 60 and older who have not been exercising regularly. The goal is to understand these differences and ev…

This study looks at how blood vessels in the arm respond to low oxygen levels in women at different stages of menopause. Researchers will measure blood flow in 75 healthy women who are premenopausal, perimenopausal, or postmenopausal. No treatments are given—this is an observatio…

This study explores why older adults often have weaker responses to the pneumonia vaccine. Researchers will compare immune cells called neutrophils in 60 healthy young (21-40) and older (65+) adults before and after receiving the Prevnar-13 vaccine. The goal is to understand age-…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain oscillations. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective…

This study looks at how aging changes the way your body uses energy and how your physical and mental abilities decline over time. Researchers will study 100 healthy adults of different ages, including people over 100, to understand why some people stay healthier longer. The goal …

This study uses advanced MRI scans to understand how the brain and kidneys change as we age, and how these changes relate to thinking abilities. Healthy adults aged 18 and older will undergo MRI and cognitive tests. The goal is to gather knowledge, not to provide treatment.

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel health in the brains of inactive older adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers. The goal is to fi…

This study looks at how estrogen levels affect the way women's bodies handle heat. Researchers will compare women before and after menopause (ages 42–64) by measuring skin blood flow, sweating, and body temperature during mild heating. No treatment is given—the goal is simply to …

This study looks at whether using common moisturizers like Vaseline or CeraVe can lower inflammation in adults aged 70 and older with dry skin. Participants will apply a moisturizer daily for 4 weeks and then stop for 4 weeks, acting as their own control. The main goal is to see …

This study is following 10,000 adults aged 18 and older to learn how muscle loss (sarcopenia), metabolic diseases, and aging are connected. Researchers will collect health data, lifestyle info, and biosamples over time. The goal is to understand how these factors together affect …

This study looks at how short-term pain, created using a capsaicin heat patch, affects the ability of older adults (ages 55-90) to learn and remember a new walking pattern on a split-belt treadmill. Researchers will measure how well participants adapt their steps and how much the…

This study looks at how getting older and having tired muscles affect a person's balance and walking. Researchers will test 140 healthy adults (young and old) before and after exercises that tire out their arms or legs. The goal is to understand these effects better, not to provi…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in normal aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and those with early Alzheimer's. They aim to better u…

This study looks at how well people can control their hip muscles and whether that affects their balance, walking, and fall risk. Researchers will compare healthy adults of different ages with people who have Parkinson's disease. The goal is to better understand what causes balan…

This study looks at how small blood vessels in frail older adults handle the stress of intense exercise. Researchers want to see if a simple technique called ischemic conditioning—using a blood pressure cuff to briefly restrict blood flow—can protect the vessels. Sixty adults age…

This study looks at how different blood pressure treatment targets (intensive vs. standard) affect artery stiffness in veterans over 60 with high blood pressure. Researchers will use a new, non-invasive method to measure artery stiffness and also analyze genetic factors. The goal…

This study aims to learn why our bodies and minds decline as we get older. Researchers will use brain scans, fitness tests, and wearable devices to track health in 770 adults aged 18-85. The goal is to better understand aging and how factors like race, sex, and lifestyle affect i…

This study looks at whether blood flow in fat tissue differs between healthy younger adults (18-35) and older adults (65-80). Participants will have their fat tissue blood flow measured, provide two small fat samples from the belly, and drink a sugary drink. The goal is to unders…

This small pilot study looks at whether whole-body electrical muscle stimulation (WB-EMS) combined with exercise can improve how nerves activate muscles in healthy older adults. Twelve participants will undergo testing before and after four weeks of twice-weekly WB-EMS sessions. …

This study tests two drugs, rapamycin and everolimus, in healthy adults aged 65-90 to find doses that safely reduce age-related cell changes. Researchers will measure drug levels and activity in blood, fat, and muscle. The goal is to learn how to mimic younger cellular function, …

This pilot study looks at whether reducing alcohol and taking probiotics can improve thinking skills and brain energy use in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to drink less and take either a probiotic or a placebo pill. The goal…

This study uses yearly PET scans to track amyloid proteins in the brains of 400 adults aged 55 and older over 5 years. The goal is to see how these proteins relate to memory loss and other thinking problems as people age. Participants also complete memory tests and questionnaires…

This study aims to understand frailty in people with HIV who are 50 or older. Researchers will measure physical performance and quality of life in 100 participants. No treatment is given; the goal is to gather information to help design future programs for healthy aging.

This study looks at how the brain changes as we age, using EEG to measure brain activity in healthy adults and mice. Researchers will also test whether tiny particles from stem cells, called exosomes, can reverse some age-related brain changes in mice. The goal is to find new way…

This study looks at healthy adults over 60 to see if brain scans and eye-tracking tests can predict who will keep good memory and thinking skills as they age. Researchers will measure a small brain area called the locus coeruleus and link it to cognitive function. No treatment is…

This study aims to understand how our sense of touch works in healthy people, so that this knowledge can be used to create prosthetic limbs that provide realistic sensory feedback. Researchers will use a technique called microneurography to record nerve signals while participants…

This study looks at how the nervous system and blood vessels change as women age. Researchers will measure blood flow in the forearm of 64 women aged 18-70. The goal is to better understand early signs of aging in the body's blood vessels.

This study looks at how aging affects muscle and heart health in people over 60 with multiple sclerosis (MS) compared to those without MS. Participants will do an exercise program for about 4 months to see how their bodies respond. The goal is to understand differences between mo…

This study follows 10,000 adults aged 18 and older over many years to see if a set of health measurements can predict how long people live and what diseases they may get. Participants undergo health screenings and are followed until death. The goal is to better understand aging a…

This study measures the temperature and humidity levels where older adults can no longer keep their body cool during exercise. Researchers will test 190 people in different conditions to find the breaking point that raises risk of heat illness. The goal is to identify dangerous e…

This study is testing a new system that continuously tracks vital signs like heart rate and oxygen levels in older adults, both in the hospital and at home. About 15 participants will use the device and provide feedback on how easy it is to use and whether it helps doctors get th…

This study aims to understand why older adults, especially frail ones, lose important immune cells (T cells) from their noses, which may make them more prone to lung infections. Researchers will compare nasal samples from 170 healthy young adults, healthy older adults, and frail …

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and test memory and physical function in 150 participants. The goal is to find factor…

This study tests whether a natural supplement from brown seaweed (fucoidan) can slow or reverse biological aging in 60 pre-frail men aged 50-80. Researchers will measure changes in DNA methylation (a marker of biological age) and inflammation. The goal is to see if activating a l…

This study looks at how older adults with hearing loss understand speech in noisy settings, like a crowded room. Researchers will test 121 people—young and older with normal hearing, plus older adults with hearing loss—using listening tasks and brain wave measurements. The goal i…

This study looks at how older women (65+) handle extreme heat and humidity. Researchers will expose 12 women to increasing humidity in a hot room to find the exact point where their bodies can no longer keep cool. The goal is to better understand heat risks for this group as clim…

This study tests whether a digital intervention can improve working memory and self-control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home brain training, with a fol…

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help reduce the risk of elder fraud.

This study tests three approaches to help older adults with HIV become more physically active: coaching, cognitive behavioral therapy for barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit to track steps. The…

This pilot study is testing whether a 14-day program combining exercise, mindfulness, sleep tips, a Mediterranean diet, and supplements is practical for adults aged 55-70 who are at risk for faster aging. Only 10 people will take part, and the main goal is to see if the study pro…

This study looks at bone marrow from 24 adults aged 65 and older who are having hip surgery. Researchers will analyze the samples to see how metabolism and gene activity differ in stem cells with certain age-related mutations. The goal is to better understand clonal hematopoiesis…

This study looks at how long-term inflammation impacts muscle function and how older adults respond to exercise. Researchers will measure muscle protein building rates in 120 older participants. The goal is to better understand age-related muscle decline, not to test a treatment.

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a hormone infusion. The goal is to underst…

This study looks at how past sports injuries and sitting too much can affect the long-term health of former athletes. Researchers will compare strength, physical activity, and overall health in 450 current and former athletes, as well as non-athletes, to understand why some peopl…

This study tests whether an online program that teaches positive emotion skills can improve mental well-being and slow biological aging. Researchers will measure changes in mood, purpose, and biological age markers in 80 adults aged 40-70 from the Chicago area. The program is sel…

This study looks at how different amounts of resistance (strength) training affect inflammation in adults aged 60-75. Participants will be placed into one of three training groups (low, medium, or high volume) or a non-exercise group for 4 weeks, followed by 4 weeks of rest. The …

This study tests whether drinking cold water (4°C) four times a day for six months can lower body fat and slow aging in healthy adults aged 50–65. Participants are split into two groups: one drinks cold water, the other drinks room-temperature water (37°C). Researchers will measu…

This early-phase study tests whether passive heat exposure (raising body temperature by about 1°C) can improve how small blood vessels widen and respond to blood flow demands in 20 healthy adults aged 18-80. Researchers aim to understand if heat can mimic some benefits of exercis…

This study looks at how mild dehydration (losing 2-3% of body weight) and then rehydrating affects inflammation, blood sugar, sleep, and strength in healthy adults aged 45-65. Researchers will measure changes in cells and body functions over 12 days. The goal is to understand if …

This study tests whether combining fasting with exercise can slow the aging process in healthy adults over 65. Two hundred forty participants will be split into four groups: exercise only, fasting only, both, or neither. Researchers will measure biological age using DNA markers a…

This study compares two online training programs for staff who care for people with dementia in assisted living facilities. About 1,764 staff and family members will take part to see if the training improves staff knowledge, attitudes, and care practices. The goal is to find the …

This study looks at why older adults respond differently to strength training. Researchers will track 300 people aged 65 and older who are at risk for mobility problems. Participants will do progressive resistance training, and scientists will measure changes in physical function…

This study looks at how different types of dietary fats affect brain function in healthy adults aged 65 to 75. Participants will follow two one-week diets: one similar to a typical North American diet and one similar to a Mediterranean diet. Researchers will measure memory and br…

This study aims to understand how people age by following healthy volunteers for life. Participants aged 20 and older undergo physical and mental tests every few years. The goal is to learn how people can adapt to aging successfully.

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study looks at how the changing seasons—summer to winter—might affect your biological age, which is a measure of how well your body is aging compared to your actual age. Researchers will track 60 healthy adults over 40 for one year, using blood or saliva samples to measure a…

This study looks at how getting older and feeling stressed can change the way we remember and find our way around. Researchers will have 85 adults aged 65-80 do a virtual navigation task while their brains are scanned. Some will be put under mild stress to see if it makes them re…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild memory problems. Researchers want to see how tau relates to thinking skills, brain activity, and the risk of future decline. About 105 people aged 55–90 who …