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This study tests whether taking MitoQ, a dietary supplement that targets cell powerhouses (mitochondria), for 3 months can improve brain artery function in healthy women aged 60 and older who have gone through menopause. Researchers will compare MitoQ to a placebo to see if it re…

This early-stage study tests a new mRNA medicine (aKL003) designed to increase levels of a protein linked to healthy aging. About 21 healthy adults aged 50–90 will receive two injections of either the active drug or a placebo. The main goal is to check safety and how well the bod…

This study tests two over-the-counter supplements to see if they can slow down immune aging in people with HIV who drink alcohol. The trial will involve 160 adults aged 40 and older. Participants will try each supplement for a period, and researchers will measure changes in immun…

This study looks at whether taking a nitrate supplement (like beetroot juice) can help older adults get more health benefits from exercise. Researchers will have 226 people aged 60 and older do a mix of endurance and strength training for 12 weeks. Half will get the supplement, h…

This study tests a new program that combines thinking exercises with physical movement to help older adults with mild memory problems. The goal is to improve balance, activity levels, and quality of life, and to slow or prevent progression to dementia. Forty-six participants aged…

This study tests a non-invasive, drug-free brain stimulation method called tACS to improve memory in healthy adults aged 65 and older. Researchers will use EEG to personalize the stimulation in real time, targeting brain networks that support memory. The goal is to see if this ap…

This pilot study will test whether combining physical exercises with non-immersive virtual reality can improve balance, thinking skills, and daily activities in adults aged 65 and older. Sixty participants will be split into three groups: one doing combined exercise and VR, one d…

This study tests a program called VIVE-AT that uses assistive technology to help older Latinos with physical disabilities improve their daily function and quality of life. About 76 participants aged 65 and older from a low-income clinic in Puerto Rico will either receive the prog…

This study will test whether interactive, game-based exercises (exergames) can improve foot muscle function, balance, and mobility in older adults. Forty healthy seniors aged 65-80 will be randomly assigned to either exergame training or standard balance exercises for 8 weeks. Re…

This study tests a gel called STYLAGE® HydroMax to see how well it reduces cheek wrinkles. About 81 adults aged 35 to 70 with mild to moderate wrinkles will receive the gel or a control. Researchers will check wrinkle improvement and safety over 6 weeks.

This study tests if a brief, phone-delivered insomnia treatment (BBTI) can improve sleep and thinking in older adults with HIV compared to a mindfulness approach. 214 participants aged 50+ with insomnia will complete 4 weeks of therapy and be followed for a year. The goal is to s…

This study tests a program called SPARK for adults aged 50 and older who have ongoing pain, depressive symptoms, and trouble moving around. Participants will receive 8 nurse visits at home to learn ways to cope with pain and improve mood. The goal is to see if this approach reduc…

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to connect with family. Over six weeks, 40 participants will try the app at home. The goal …

This study tests whether voice therapy exercises (PhoRTE®) work as well through video calls as they do in person for adults aged 55 and older with age-related voice problems. Thirty participants will receive four therapy sessions either face-to-face or via telehealth. Researchers…

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare active stimulation plus targete…

This study looks at why older adults may need less anesthesia during major abdominal surgery. Researchers will compare younger and older patients to see if inflammation linked to aging plays a role. Participants will have their anesthesia doses tracked, brain activity monitored, …

This study looks at whether a 12-week aerobic exercise program can improve the immune system of adults aged 60 and older living in care homes. Participants will either exercise three times a week or continue their usual routine. Researchers will measure changes in blood markers a…

This study looks at whether a dietary supplement called TA-65 can help blood vessels work better as people age. Researchers will measure blood vessel function in healthy younger and older adults, as well as people with coronary artery disease. The goal is to see if activating tel…

This study looks at how healthy young and older adults use their brains to make memory decisions. Researchers will use brain scans to see if older adults rely more on combining past experiences. The goal is to understand normal aging, not to treat any disease.

This study aims to understand why some people live to 95 or older by looking at their genes, proteins, and lifestyle. Researchers in Hong Kong will collect blood samples and health information from 2500 long-lived individuals. The goal is to find biomarkers and habits that promot…

This study will check if common weight loss medications (semaglutide or tirzepatide) combined with lifestyle coaching can reduce a person's biological age. Researchers will measure aging using a special blood test called LinAge2. The study includes 440 adults aged 40-89 who are o…

This study will test whether having nursing students wear an aging simulation suit helps them understand the physical and emotional challenges older adults face. About 102 third-year nursing students will take part. The goal is to see if this hands-on experience improves their at…

This study looks at whether measuring walking speed during regular check-ups can help spot early signs of physical decline in veterans aged 60 and older. The goal is to catch problems before they lead to falls or hospital stays. Over 10,000 veterans will take part across VA prima…

This study looks at fat that builds up inside muscles as people age, which may cause inflammation and damage. Researchers will have 16 older adults (ages 65-80) do a 12-week calf exercise program. Before and after, they will measure muscle strength, take CT scans, and collect sma…

This study is testing a digital platform called MEVA that measures cognitive wellness in healthy adults aged 55 to 75. Researchers want to see if the platform gives consistent results when used twice, about two weeks apart, and whether older adults find it easy and acceptable to …

This study aims to create a comprehensive health database for middle-aged and elderly people in Taiwan. Researchers will measure brain volume, sleep patterns, and cognitive changes in 250 volunteers aged 40 and older. The goal is to better understand healthy aging, not to test a …

This study explores whether involving seniors in designing their own physical activity programs leads to better long-term exercise habits. Researchers will enroll 60 adults aged 60 and older who are not yet regularly active. Participants will co-create their exercise plans and be…

This study looks at whether a 12-week Tai Chi program can improve balance in adults aged 55 and older who live in the community. About 90 participants will be randomly assigned to either Tai Chi classes or health education. The researchers will measure balance, physical function,…

This study looks at whether motivational text messages written by humans or by artificial intelligence (AI) can help middle-aged and older adults (40+) who are not very active become more physically active. Participants will wear a Fitbit and a thigh monitor, play brain games on …

This study looks at whether an electronic health assessment (eCGA) can help family doctors better understand frailty in adults aged 65 and older. About 120 participants will use the tool and some will also get a personalized exercise program. The goal is to see if this approach c…

This study tests a new digital training program that uses animated stories to teach older adults in nursing homes about common health risks like falls and medication safety. Researchers will compare the knowledge and frailty levels of 66 participants who either receive the animat…

This study tests whether a three-session education program can help adults aged 65 and older improve their confidence, healthy habits, and ability to understand health information. One hundred participants from primary care centers will either take the program or receive usual ca…

This study will follow 2,800 adults aged 55 and older in Hangzhou, China, for many years. Researchers will collect information on diet, lifestyle, thinking skills, brain scans, and gut bacteria. The goal is to learn more about healthy aging and cognitive decline, not to test a tr…

This study tests whether a safe, non-invasive device that stimulates the vagus nerve can improve memory in healthy older adults. Researchers will compare memory performance with and without stimulation in 150 people aged 65-80 and a younger group. They also want to see if gut hea…

This study looks at whether adding neck-strengthening exercises to standard balance training can help older adults at risk of falling. Researchers will measure balance, neck strength, and eye movements in 110 people aged 65 and older. The goal is to find better ways for physical …

This study aims to validate an Italian version of the dynamic Neurocognitive Adaptation (dNA) Scale, a questionnaire that measures how much older adults engage in physical, mental, creative, and social activities. Researchers will recruit 265 people aged 65 and older, including t…

This early-stage study tests whether age-related vision problems are caused by changes in brain wave patterns. Researchers will use noninvasive brain stimulation to try to restore these patterns and improve how older adults see contrast and 3D motion. The study involves 240 healt…

This study looks at how well the body handles phosphate from food as people age and whether men and women respond differently. Researchers will give a phosphate drink to 40 healthy adults (young and older) and measure blood levels. The goal is to understand normal changes in kidn…

This study looks at how short bursts of aerobic exercise might help the brain learn and adapt better in older adults and stroke survivors. About 48 participants will do cycling at different intensities, then complete memory and movement tasks while their brain activity is measure…