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Can a quick bike ride boost brain power? new study investigates

NCT ID NCT06950060

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Participants will complete learning tasks and brain tests to see if exercise helps improve movement and memory. The goal is to find simple, low-cost ways to support brain health as we age or recover from a stroke.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For All Participants: * Able to provide informed consent * Right-handed (for TMS consistency) * English-speaking * Clearance for moderate-intensity aerobic exercise * Able to safely sit and pedal a stationary cycle ergometer * No contraindications to TMS (e.g., no metal in skull, pacemakers, or seizure history) Younger Adults (18-35): * No history of neurological or psychiatric conditions * Not currently on medications that affect the central nervous system Older Adults (60-85): * No diagnosis of dementia * Independent in activities of daily living * No stroke history Stroke Survivors (40-85): * At least 6 months post-stroke (chronic phase) * Medically stable and cleared for aerobic exercise * Able to engage in motor learning task (with or without hemiparetic adaptations) Exclusion Criteria: * History of epilepsy or seizures * Current substance abuse or uncontrolled psychiatric disorder * Severe cardiovascular disease or unstable medical condition * Pregnancy * Contraindications to TMS or exercise testing (e.g., implanted neurostimulators, severe hypertension) * Participation in another interventional trial within the past 30 days

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome Cognitive Dysfunction movement disorder Neurologic Manifestations stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Cognitive decline Motor dysfunction Neuroplasticity Stroke, chronic

Contacts and locations

Locations

  • CH19 933 19th St S

    Birmingham, Alabama, 35233, United States

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