COGNITIVE DECLINE

This study tests whether a daily supplement called Sabroxy® (made from the Oroxylum indicum tree bark) can improve insulin resistance and memory in 140 adults aged 40-80 with mild cognitive impairment and insulin resistance. Participants take either the supplement or a placebo fo…

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium, cognitive decline, and disability. About 2,766 participants will be randomly assigned to one of two an…

This study is testing a new automated tool that helps primary care doctors quickly screen older adults for early signs of memory loss or cognitive decline. About 100 Spanish-speaking adults aged 60 and older will use an iPad to complete symbol matching and voice tasks. The goal i…

This study looks at whether combining the MIND diet (a mix of the Mediterranean and DASH diets) with aerobic exercise can help prevent thinking and memory problems in Black adults ages 35-75 who have high blood pressure. Participants will either receive food delivery, cooking les…

This study is testing whether helping older adults (70+) keep their blood pressure under control can prevent memory loss and dementia. Researchers will compare a special care program (with decision support and team-based care) to usual care in 4,000 participants. The goal is to s…

This study tests whether playing video games or tossing a ball can help improve eye-hand coordination in people aged 60 and older with mild cognitive impairment (MCI). Poor coordination can make daily tasks like dressing or eating harder. The study will compare the two activities…

This study tests whether a daily broccoli sprout extract can improve memory and thinking in 100 adults aged 55-85 who have mild cognitive impairment (some memory loss but not dementia). Participants will take the extract or a placebo for 12 weeks, and researchers will measure cha…

This study tests a 12-week mindful walking program for older South Asian family caregivers (age 45+) who care for someone with cognitive disabilities and feel stressed. Half of the 50 participants will learn mindful walking and use a Fitbit, while the other half continues usual c…

This study explores whether adding immersive virtual reality (VR) 360-degree videos to aerobic exercise can improve memory, attention, and thinking skills in older adults with mild cognitive impairment (MCI). About 34 people aged 60 and older with MCI will either do aerobic exerc…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, have MRI brain scans, and complete memory and physical te…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking in breast cancer patients undergoing chemotherapy. About 90 women with early-stage breast cancer will be split into three groups: memantine plus exercise, mema…

This study tests whether a technology-assisted block training program can improve cognitive function, hand dexterity, and grip strength in community-dwelling older adults aged 65 and older. Participants will engage in block-building activities with technological support, and rese…

This study tests whether a door-through-door rideshare service, where a trained companion helps participants from their home into the doctor's office, can reduce missed medical appointments for older adults with Alzheimer's or related dementias. About 120 participants will be ran…

This study tests whether a mobile health program (mPATH) can improve memory and sleep in low-income older adults who are not very active and have trouble sleeping. About 176 participants will use a smartphone app to guide physical activity. The goal is to see if this approach hel…

This study tests whether playing soft sounds during deep sleep can improve memory and slow cognitive decline in older adults. Sixty people aged 60-85 with mild memory problems will use a home device for 4 weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests an internet-based cognitive behavioral therapy (CBT) program called Good Days Ahead for older adults (50+) who have depression after an ICU stay. The goal is to see if treating depression can slow down memory and thinking problems. About 300 participants will be …

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study looks at how removing a type of brain tumor called a meningioma affects a person's thinking and memory over a year. Researchers will test 50 adults before and after surgery to see if their cognitive skills change. The goal is to better understand the long-term effects …

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel health in the brains of inactive older adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers. The goal is to fi…

This study looks at whether a gentle electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare results from 110 participants aged 60-95, including both people with MCI and healthy older…

This study looks at whether sleep and body-clock patterns can help predict delirium (sudden confusion) after major orthopedic surgery in adults aged 70 and older. Researchers will track sleep with a watch worn for two weeks before surgery and collect blood samples to check for Al…

This study tests a goals-based exercise program designed with the Black community to help adults aged 45-65 become more active. The goal is to see if the program improves exercise habits and reduces risks linked to cognitive decline, heart disease, and diabetes. Participants will…

This study looks at how past traumatic brain injuries (TBI) may affect thinking skills and blood vessel health in military personnel and veterans. Researchers will measure substances in the blood linked to blood vessel damage, inflammation, and brain cell loss. They aim to find p…

This study is testing a digital meditation program to see if it can improve thinking and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. The goal is to find the best amount of meditation needed to help with mem…

This study aims to see if a quick cognitive test, given during regular check-ups, can help doctors detect early memory problems or dementia in underserved communities. Over 45,000 adults without prior diagnosis will take part across 24 clinics. The goal is to improve early detect…

This study is looking for DNA markers that might predict the risk of silent strokes in older adults having a minimally invasive heart valve replacement called TAVR. Researchers will measure DNA methylation in blood samples before and after the procedure and compare it to brain sc…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to learn how to better predict and prevent these complic…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants fro…

This study looks at whether successfully treating obstructive sleep apnea (OSA) in older adults can improve memory and lower Alzheimer's-related brain changes. About 200 cognitively normal adults aged 55-85 with moderate-to-severe OSA will either receive immediate treatment (CPAP…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see which factors—like insulin resistance or inflammation—are linked to changes in memory, proce…

This study looks at whether bladder tumor surgery and general anesthesia cause short-term memory or thinking problems. Researchers will test 42 adults aged 18-80 before and after surgery using simple mental quizzes and blood tests for brain injury markers. The goal is to understa…

This study compares two forms of DHA (a type of omega-3 fat) in 153 older adults aged 55-82 who have early signs of memory decline. One group takes a special form called LPC-DHA, the other takes standard DHA, for 24 weeks. Researchers measure DHA levels in spinal fluid and blood,…

This study will follow 5,000 middle-aged and older Tzu Chi volunteers in Taiwan to see how vegetarian and plant-based diets affect healthy aging. Researchers will measure thinking skills, muscle mass, grip strength, and signs of frailty. The goal is to learn which eating patterns…

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain function in healthy older adults and people with very early Alzheimer's disease. Participants will receive daily stimulation sessions for two weeks, w…

This study is testing whether combining biological tests (like brain scans and blood work) with psychological and social factors can help doctors diagnose Alzheimer's disease earlier and more accurately. Researchers will follow 80 people with cognitive decline and their caregiver…

This study aims to understand why some people experience changes in thinking and memory as they get older. Researchers will use brain scans (MRI and PET) and memory tests to detect early signs of decline in 300 healthy adults aged 60 and older. The goal is to find better ways to …

This study looks at how different types of dietary fats affect thinking and memory in adults who have mild memory complaints. Over 88 participants will eat a special snack each day for one week. Researchers will measure brain function and gut health to see if certain fats can hel…

This study looks at how natural plant compounds (flavonoids) from a Mediterranean-style diet are broken down by gut bacteria and whether these byproducts help protect memory and thinking in older adults. Researchers will measure changes in blood, stool, and cognitive test scores …

This study tests whether a special program can reduce confusion (delirium) after surgery in older adults. Researchers will screen patients aged 60 and older before their operation to find those at highest risk. Those identified will receive extra care recommendations and educatio…