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Thin air for thicker brains? study tests hypoxia against aging

NCT ID NCT05048680

Knowledge-focused Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. The goal is to find new ways to preserve cognitive and physical function as we age.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hypoxia (low-oxygen air) and/or exercise training
What this could lead to
If it works, this could point toward a simple, drug-free way to help maintain brain health and slow cognitive decline in older adults.
What could go wrong
This is an early-stage study with only 64 participants, looking at short-term changes in blood flow, not long-term health outcomes. The benefits may be small or not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2021

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 60 to 80 years of age; * Being physically inactive (less than 150 min/week of moderate to intense physical activity); * No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program; * Health coverage; * Being able to provide written fully informed consent. Exclusion Criteria: * Body-mass index \>30 kg/m2; * Smoking (\> cigarettes/day); * Alcohol use (\> 10g/day); * Mental disorder or history of mental disorder; * Beta-blockade treatment; * Inability or refusal to provide informed consent; * No health coverage * People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials; * People deprived of freedom by judicial or administrative decision; * People subject to legal protection, who cannot be included in clinical trials.

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Conditions

The condition(s) this trial relates to.

brain disorder brain hypoxia - ischemia Cognitive Dysfunction Hypoxia Hypoxia, Brain Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Brain diseases Cerebral hypoxia Cognitive decline Exercise Healthy aging Hypoxia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Grenoble Alpes

    RECRUITING

    La Tronche, Auvergne-Rhône-Alpes, 38700, France

More trials for these conditions

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