University Hospital, Grenoble

This study is a French registry that will follow 100 adults with high blood pressure who undergo a procedure called renal denervation, which uses radiofrequency or ultrasound to calm overactive kidney nerves. The goal is to see how much blood pressure drops one year after the pro…

This study looks at how different types of anesthesia affect blood pressure stability during organ removal surgery in brain-dead donors. About 270 donors will be randomly assigned to receive a gas anesthetic, a painkiller, or no anesthesia. The goal is to see which approach keeps…

This study tests whether specially trained nurses can safely diagnose and manage non-traumatic chest pain in the emergency department. About 182 adults with chest pain will be randomly assigned to either nurse-led or standard doctor-led care. The goal is to see if nurse-led care …

This study aims to see if Alzheimer's disease can be detected by measuring specific proteins (amyloid and tau) in stool samples. Currently, diagnosis often happens late and requires invasive or expensive tests. Researchers hope this simple, non-invasive method could lead to earli…

This study looks at two types of exercise for frail adults aged 70 and older: high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT). The goal is to see which one better improves heart and lung fitness and reverses age-related decline. Participa…

This study tests whether giving a specific pain-relief injection (erector spinae plane block) early after a severe chest injury can reduce the number of days a patient needs a breathing machine. The trial will include 400 adults with three or more broken ribs from blunt chest tra…

This study tests whether a low dose of morphine can help people with severe COPD who need a breathing mask (non-invasive ventilation) during a flare-up. The goal is to reduce early failure of the mask by easing pain, shortness of breath, and anxiety. About 24 adults will take par…

This study tests if a liquid medicine called midazolam can help elderly patients with moderate to severe memory problems feel calmer and accept care they usually resist. About 30 hospitalized patients will receive the medicine before care routines. The goal is to reduce their res…

This early study tests if a procedure called arterial embolization, using a substance called Lipiodol, is safe for people with painful hand osteoarthritis that hasn't improved with standard treatments. Fifteen participants will receive the procedure and be monitored for 6 months …

This study looks at whether measuring carbon dioxide in a person's breath (EtCO2) can help doctors quickly tell how serious a COPD flare-up is. Researchers will watch 240 adults who come to the emergency room with breathing trouble. If EtCO2 works well, it could reduce the need f…

This study is testing a new device that uses light to measure pulse wave velocity and blood pressure without needing a traditional cuff. Researchers will compare the device's readings to standard equipment in 27 healthy adults. The goal is to see if this light-based method is rel…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel health in the brains of inactive older adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers. The goal is to fi…

This study collects tumor tissue from 60 people with colorectal cancer before they start chemotherapy. Researchers will grow mini-tumors in the lab to study how the immune system and cancer cells interact. The goal is to understand why some tumors don't respond to treatment and f…

This study looks at blood samples from 30 people who have had a Pseudomonas aeruginosa infection to find and create special antibodies that could attack this bacteria. The goal is to develop a new treatment for infections that are resistant to many antibiotics. Participants give …

This study follows 1,600 adults aged 60 and older who are hospitalized with respiratory infections like flu, COVID-19, or RSV. Researchers measure changes in daily living skills, such as bathing and cooking, to understand how these infections affect independence. The goal is to i…

This study asks adults with type 1 diabetes who use a closed-loop insulin system how they feel about the special 'physical activity mode' designed to prevent low blood sugar during exercise. Researchers will use a questionnaire to gather feedback from up to 900 participants. The …

This study is testing a way to find early liver scarring (fibrosis) in people who don't have symptoms yet. Doctors will use a simple blood test called FIB-4, followed by a more detailed test if needed. The goal is to see if this approach helps catch serious liver problems earlier…

This study looks at a new way for family doctors to work with a hospital to find liver scarring (fibrosis) early. It will include 150 adults who are at risk due to alcohol, diabetes, or other factors. The goal is to see if patients get the right follow-up care after a simple, non…

This study is a planning step for future clinical trials. It will test brain imaging and heart monitoring equipment in 150 healthy volunteers, people with Parkinson's disease, and those with paralysis. The goal is to make sure the tools and procedures work well before larger stud…

This study looks at whether a type of scan called SPECT/CT can help doctors see if treatment is working in men with advanced prostate cancer. The treatment uses a radioactive drug (Lu-177 PSMA) that targets cancer cells. Researchers want to see if SPECT/CT, which is cheaper and m…