COGNITIVE DECLINE
Clinical trials for COGNITIVE DECLINE explained in plain language.
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Blood test breakthrough could spot Alzheimer's early
Diagnosis CompletedThis study tested a new blood test to see if it can help diagnose Alzheimer's disease. Researchers measured two specific markers in the blood of 200 people, including those with Alzheimer's and healthy volunteers, over 24 months. The goal was to see if these markers can reliably …
Matched conditions: COGNITIVE DECLINE
Sponsor: Amoneta Diagnostics SAS • Aim: Diagnosis
Last updated May 20, 2026 11:55 UTC
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Heart disease raises dementia risk: can simple lifestyle changes save your memory?
Prevention CompletedThis study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older with a history of cardiovascular disease who were not alrea…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Rush University Medical Center • Aim: Prevention
Last updated May 26, 2026 06:48 UTC
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New hope: culturally tailored program may shield HIV+ latinos from memory loss
Prevention CompletedThis study tested a health program designed for older Latino adults living with HIV to see if it could help prevent memory and thinking problems. Thirty participants joined the program, which was tailored to their culture and needs. The main goal was to see if the program was pra…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: University of Miami • Aim: Prevention
Last updated May 26, 2026 06:47 UTC
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Robot teachers aim to keep Seniors' minds sharp
Prevention CompletedThis study tested whether an 8-week course led by a robot (called Kebbi) could help prevent or delay cognitive decline in older adults. 80 people aged 65 and older with mild memory problems took part. The robot taught lessons and led interactive games to boost thinking, mood, and…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: National Taiwan Normal University • Aim: Prevention
Last updated May 22, 2026 13:52 UTC
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Chicken soup for the brain? study tests supplement for memory decline
Prevention CompletedThis study tested whether a chicken extract and a peptide supplement could help prevent memory and thinking decline in older adults without dementia. 276 people aged 55-75 with either mild memory concerns or mild cognitive impairment took the supplements or a placebo for two year…
Matched conditions: COGNITIVE DECLINE
Phase: EARLY_PHASE1 • Sponsor: Brand's Suntory Asia • Aim: Prevention
Last updated May 22, 2026 13:50 UTC
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Fit mind program shows promise in reducing Alzheimer's risk
Prevention CompletedThis study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 older adults living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the program m…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Burdur Mehmet Akif Ersoy University • Aim: Prevention
Last updated May 15, 2026 11:57 UTC
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Zapping the brain to save memories: new hope for MCI?
Symptom relief CompletedThis study tested if a noninvasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain areas o…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Palo Alto Veterans Institute for Research • Aim: Symptom relief
Last updated May 26, 2026 06:59 UTC
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Virtual time travel: VR nostalgia lifts spirits and sharpens minds in seniors
Symptom relief CompletedThis study tested whether a virtual reality program featuring nostalgic scenes could improve emotional well-being and thinking skills in older adults (65+) with mild memory problems. Participants used VR headsets twice a week for about 20 minutes, reliving familiar experiences. R…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: National Taiwan Normal University • Aim: Symptom relief
Last updated May 26, 2026 06:57 UTC
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Turning the tide: new exercise study aims to boost balance and brain power in diabetes patients
Symptom relief CompletedThis study tested whether turning-based dual-task training (exercises that combine movement and thinking) could improve balance and mild cognitive issues in 50 adults with diabetic peripheral neuropathy. Participants were aged 50 and older and had both balance problems and mild c…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Foundation University Islamabad • Aim: Symptom relief
Last updated May 26, 2026 06:47 UTC
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Brain blossom supplement tested for memory boost in older adults
Symptom relief CompletedThis study tested whether a natural supplement called Brain Blossom can improve memory and thinking skills in adults aged 50 to 70. Sixty participants took either the supplement or a placebo for 8 weeks and completed memory tests and questionnaires. The goal was to see if the sup…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Bio Nature Health • Aim: Symptom relief
Last updated May 26, 2026 06:47 UTC
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Brain games show promise for Alzheimer's patients
Symptom relief CompletedThis study looked at whether digital or physical brain exercises could help older adults with mild to moderate Alzheimer's disease. Over 500 people in Portugal took part. The goal was to see if these activities could improve memory, thinking, mood, and quality of life.
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Rsocialform - Geriatria, Lda • Aim: Symptom relief
Last updated May 26, 2026 06:47 UTC
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Can a Live-Streaming group program boost brain health in seniors?
Symptom relief CompletedThis study tested a live-streaming group program called Brain Health Together for older adults with mild memory problems. 208 participants joined from home to learn about brain-healthy habits like exercise, social connection, and healthy eating. The goal was to see if the program…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated May 26, 2026 06:46 UTC
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Common heart pill may shield brain tumor patients from memory loss
Symptom relief CompletedThis study tested whether ramipril, a common blood pressure medicine, could help prevent memory loss in 75 people with glioblastoma who were receiving brain radiation and chemotherapy. Participants took ramipril during treatment and for four months after. Researchers measured mem…
Matched conditions: COGNITIVE DECLINE
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated May 26, 2026 06:45 UTC
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Brain games and light exercise aim to sharpen MS minds
Symptom relief CompletedThis study tested two different computer-based brain training programs, combined with light physical activity, to see if they could improve thinking skills like memory and attention in people with multiple sclerosis (MS). Forty adults with MS who had some cognitive complaints too…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated May 22, 2026 13:59 UTC
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Can mushroom gummies boost your brain? small study says maybe
Symptom relief CompletedThis study tested whether Auri Super Mushroom Daily Gummies can help adults aged 30 and older who struggle with forgetfulness, focus, low energy, and mood. Thirty-five participants took two gummies daily for 8 weeks and completed memory and attention tests. The goal was to see if…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Auri Nutrition • Aim: Symptom relief
Last updated May 20, 2026 11:54 UTC
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Brain training after hospital confusion shows promise for older adults
Knowledge-focused CompletedThis study tested whether starting cognitive training early in the hospital and continuing it at home for 12 weeks could improve thinking and memory in older adults (65+) who experienced delirium. 283 participants were randomly assigned to receive the training or usual care. The …
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated May 26, 2026 07:01 UTC
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Light on the head: new study tests brain boost
Knowledge-focused CompletedThis study looked at whether shining a special light on the head (called transcranial photobiomodulation) can improve blood flow in the brain and help with thinking skills. Researchers tested 24 adults aged 18 to 80. The goal was to understand how the light affects brain health, …
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: The University of Texas at Arlington • Aim: Knowledge-focused
Last updated May 26, 2026 06:57 UTC
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New study creates brain test norms for older adults
Knowledge-focused CompletedThis study gathered cognitive test results from 1,300 healthy adults aged 50 and older to create a standard reference for the BrainCheck device. The goal was to establish normal score ranges and check if the test produces consistent results over time. Participants completed compu…
Matched conditions: COGNITIVE DECLINE
Sponsor: BrainCheck, Inc. • Aim: Knowledge-focused
Last updated May 26, 2026 06:51 UTC
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Exercise might keep your brain young and your gut happy
Knowledge-focused CompletedThis study looked at how exercise affects memory and the gut microbiome in healthy adults aged 45-65 who were not regular exercisers. 52 participants completed the study, which measured changes in memory tasks and gut bacteria. The goal was to understand the connection between ph…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: King's College London • Aim: Knowledge-focused
Last updated May 26, 2026 06:50 UTC
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Pain may worsen motor learning in older adults, study finds
Knowledge-focused CompletedThis study looked at how short-term pain affects the ability to learn and remember new movement patterns in 61 healthy young and older adults. Researchers tested walking patterns and memory tasks to see if pain impairs learning and if older adults are more affected. The goal is t…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: University of Delaware • Aim: Knowledge-focused
Last updated May 26, 2026 06:50 UTC
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Pilot study tests combo of lifestyle, meds, and supplements for healthier aging
Knowledge-focused CompletedThis pilot study explored whether combining lifestyle changes, risk factor management, medications, and supplements could improve motor, cognitive, and immune function in aging adults. 23 sedentary adults aged 50-70 participated. The main goal was to see if the program was feasib…
Matched conditions: COGNITIVE DECLINE
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated May 26, 2026 06:49 UTC
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Beetroot juice may boost aging brains and arteries
Knowledge-focused CompletedThis early-stage study tested whether drinking beetroot juice (rich in natural nitrates) could improve blood vessel stiffness and brain blood flow in 16 adults aged 50-79. Participants were randomly assigned to drink either nitrate-rich or nitrate-free beetroot juice. The goal wa…
Matched conditions: COGNITIVE DECLINE
Phase: EARLY_PHASE1 • Sponsor: Gary L. Pierce, PhD • Aim: Knowledge-focused
Last updated May 26, 2026 06:46 UTC
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Brain zapping study hints at new way to fight memory loss
Knowledge-focused CompletedThis study tested whether a gentle electrical current applied to the scalp (called tACS) at a specific frequency (40 Hz) could strengthen brain waves linked to memory in 30 healthy older adults aged 50-80. The goal was to see which brain areas to stimulate for the best effect, wh…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: The National Brain Mapping Laboratory (NBML) • Aim: Knowledge-focused
Last updated May 26, 2026 06:44 UTC
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Digital tool spots hidden memory issues in seniors
Knowledge-focused CompletedThis study tested a digital tool that scans electronic health records to find older adults who may have undetected memory problems or early Alzheimer's disease. Over 3,400 patients aged 65 and older from primary care clinics took part. The goal was to see if the tool could help i…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated May 22, 2026 14:04 UTC
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Brain games before surgery may predict delirium risk in seniors
Knowledge-focused CompletedThis study looked at whether older adults (60+) can play a short set of brain-training games on a tablet before major surgery. The goal was to see if their first-time performance could help predict who might experience confusion (delirium) after the operation. Researchers tested …
Matched conditions: COGNITIVE DECLINE
Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated May 22, 2026 14:01 UTC
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Doctors use virtual patients to see if new Alzheimer's blood test improves care
Knowledge-focused CompletedThis study looked at whether a new blood test for Alzheimer's disease helps doctors make better decisions. Instead of real patients, 178 neurologists used virtual patient simulations. The goal was to see if having the blood test results changed how doctors diagnosed and treated s…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: Qure Healthcare, LLC • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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New drink tested for heart and brain boost in small study
Knowledge-focused CompletedThis study looked at whether drinking a KETO5 XOGenius beverage every day could improve markers of heart health, blood pressure, cholesterol, and thinking skills. Six healthy adults aged 18 to 50 took part. The goal was to see if the drink might lower risks for heart disease and …
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: The University of Texas at Arlington • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC
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Can bilingualism and exercise slow brain aging? new study investigates
Knowledge-focused CompletedThis study looked at whether regular exercise and being bilingual can help older adults maintain their language and thinking skills. Over 200 healthy older adults took part, with some doing a home-based high-intensity workout program. The goal was to measure changes in fitness, l…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: University of Agder • Aim: Knowledge-focused
Last updated May 18, 2026 12:11 UTC
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Soul food makeover: can a MIND+SOUL diet boost heart and brain health?
Knowledge-focused CompletedThis study looked at whether older African Americans (55+) with heart disease risk factors could follow a special diet called MIND+SOUL. The diet combines brain-healthy foods with soul food traditions. Researchers measured how many people stuck with the diet and checked changes i…
Matched conditions: COGNITIVE DECLINE
Phase: NA • Sponsor: University of Kansas Medical Center • Aim: Knowledge-focused
Last updated May 18, 2026 11:58 UTC