COGNITIVE DECLINE

This study tests whether a personalized, data-driven hearing rehabilitation program works better than standard care for older adults with mild to moderate hearing loss. The goal is to improve hearing and possibly slow down age-related cognitive decline. Two hundred first-time hea…

This study looks at whether using hearing aids over the long term can slow down memory loss and reduce the risk of dementia in older adults. It follows 629 people aged 70-84 who already took part in a previous hearing study. Researchers will compare those who got hearing help rig…

This study tests whether taking high-dose vitamin D (4,000 IU daily) for 3.5 years can correct vitamin D deficiency and slow down memory and thinking decline in older adults aged 65-90. Researchers will compare high-dose to standard-dose vitamin D in 180 participants with normal …

This study tests whether a device that delivers light and sound stimulation for 60 minutes each day can slow the decline in memory and daily living skills in people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inac…

This study tests whether a daily soy-based supplement called Equol can slow down stiffening of the arteries, reduce small blood vessel damage in the brain, and help prevent memory decline. Researchers will follow 369 adults aged 65-85 for two years, using scans and thinking tests…

This study is testing a new automated tool that helps primary care doctors quickly screen older adults for early memory and thinking problems. The tool uses simple symbol matching and voice tasks on an iPad to give a risk score. Researchers hope it will make screening easier and …

This study tests a program called ADL+2.0 designed to prevent or delay cognitive decline in adults aged 60 and older who have memory concerns but no dementia. Participants will receive a mix of cognitive training, physical exercises, and wellness activities, either remotely or co…

This study tests whether a 24-week program combining aerobic exercise, cognitive training on a mat, and turmeric (with black pepper) can prevent cognitive decline in people aged 55-70 who have insulin resistance and memory concerns. Participants will be randomly assigned to recei…

This study tests whether an online, coach-assisted program called Luci can help adults aged 50 to 75 improve their lifestyle habits—like being more active, eating a Mediterranean diet, and staying mentally engaged—to reduce their risk of dementia. About 370 participants with modi…

This study tests whether a digital platform called ToBrainHealth can help people aged 40-75 adopt and stick to brain-healthy habits like exercise, better sleep, and social activities. 120 volunteers will be split into three groups: one gets general advice, another gets personaliz…

This study tests whether a special diet called the MIND diet can help prevent memory loss and dementia in people who have had a stroke. Researchers will compare the MIND diet to usual post-stroke care in 250 adults aged 55 and older. The goal is to see if the diet protects the br…

This study tests a nutritional product called Radicle Clarity™ 25_RAM to see if it can improve cognitive function and reduce brain fog in adults aged 40 and older. Participants take the product or a placebo for 8 weeks and answer surveys about their thinking, fatigue, and sleep. …

This study tests whether a daily probiotic capsule can improve memory and thinking in adults aged 50 and older. Over 6 months, 110 participants will take either the probiotic or a placebo, then switch. Researchers will also look at how diet and gut bacteria influence the results.

This study looks at whether a drug that increases dopamine (carbidopa/levodopa) can improve thinking speed, walking, and mood in older adults with depression. About 100 people aged 60 and older with depression and slow thinking or walking will take the drug or a placebo. The goal…

This study planned to see if eating blueberries for 12 weeks could improve thinking skills in adults aged 65 and older with mild memory complaints. Participants would have eaten whole blueberries or a powder, compared to a placebo. However, the study was withdrawn before any volu…

This study is creating a large database of information from 250 older adults (65+) having surgery. Researchers collect blood samples, brain wave recordings, and memory tests before and after surgery. The goal is to find patterns that could one day help predict who might experienc…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will follow 505 adults aged 50 and older to see how many experience mental fogginess (called postoperative cognitive dysfunction) up to 4.5 months after surgery. The goal …

This study looks at whether certain mental and physical activities can slow the normal decline that comes with aging. Researchers will follow 400 healthy Malaysian adults aged 60 and older for four years, measuring changes in thinking, brain structure, and other health markers. T…

This study aimed to understand how changes in blood pressure when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare those with and without orthostatic hypotension (low blood pressure upon standing) using …

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that may lead to thinking problems in CKD patients. Participan…

This study looks at whether treating chewing problems in older adults can improve memory and thinking. Eighty people aged 65 to 80 with poor chewing ability will get dental work to fix their bite. Researchers will test their memory and brain function before and after treatment to…

This study looks at whether stereotactic radiosurgery (a precise type of radiation) for brain tumors causes thinking or memory problems. About 80 adults with brain metastases or benign meningiomas will take memory tests and quality-of-life surveys before and after treatment. Rese…

This study uses a special PET scan to measure tau protein buildup in the brains of healthy older African Americans. The goal is to learn how these brain changes relate to normal aging versus early Alzheimer's disease. Participants are already part of a long-term study and will ha…