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Stanford launches study to predict brain fog after surgery in seniors

NCT ID NCT03839784

Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

Researchers at Stanford are creating a database to better understand why some older adults experience memory or thinking problems after surgery with anesthesia. They will collect information from 250 patients aged 65 and older, including blood samples, brain wave recordings, and thinking tests before and up to a year after surgery. The goal is to build a model that can predict who might have these problems, so doctors can personalize anesthesia care in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a tool that predicts which older patients are at risk for memory or thinking problems after surgery with anesthesia.
What could go wrong
This is an early-stage data-gathering study, not a treatment trial. It may not produce a usable prediction model, and results may not apply to all older patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2020

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Stanford Hospital geriatric patients having surgery.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 65 years old (inclusive) * Non cardiac general elective surgery * General anesthesia is expected for 2+ hours Exclusion Criteria: * Alzheimer's * Dementia * Parkinson's * History of neurodegenerative diseases * Medication for depression (ie. Benzodiazepines) * Alcoholism * Discretion of PI

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia; adverse effect Anesthesia; reaction Cognitive change Cognitive decline Cognitive impairment Postoperative delirium

Contacts and locations

Locations

  • Stanford Medical Center

    Stanford, California, 94305, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.