COGNITIVE CHANGE

This study tests a program that combines motivational interviewing with text messages to help Native American elders (age 50+) with sleep apnea use their breathing machine more regularly. Better use of the machine may improve sleep and lower the risk of memory problems. About 300…

This study looks at whether different types of exercise can improve brain health and reduce the risk of Alzheimer's disease in older African Americans. Researchers will compare a cardio-dance fitness program to a strength, flexibility, and balance program over six months. Partici…

This study tests whether a 6-month online educational program called Brain Health PRO can help people at risk for dementia make lasting lifestyle changes—like improving diet, exercise, sleep, and social connections. About 700 Canadian adults with mild memory concerns or risk fact…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking in breast cancer patients undergoing chemotherapy. About 90 women with early-stage breast cancer will be split into three groups: memantine plus exercise, mema…

This study looks at whether a 16-week high-intensity interval training (HIIT) program can improve brain function and heart health in women with breast cancer who are receiving chemotherapy. About 30 women will participate, and their thinking skills and fitness will be measured be…

This study tests whether a gentle, non-invasive brain stimulation technique called HD-tDCS can improve word-finding difficulties in people who had a traumatic brain injury at least one year ago. About 24 adults will receive either real or fake stimulation during word and memory t…

This study tests whether customizing the electrical dose of electroconvulsive therapy (ECT) for each person can better treat depression and reduce memory problems compared to a standard dose. Researchers will enroll 50 older adults with depression who are already scheduled for EC…

This study checks whether keeping indoor temperatures at 26°C (about 79°F) is enough to protect healthy, active young adults (ages 18-29) from heat strain. Participants will spend 8 hours in a warm room, either resting in light clothes or doing light exercise in extra layers. Res…

This study aims to understand how chemotherapy given before surgery for advanced ovarian cancer affects thinking skills like memory and attention. Researchers will enroll 18 adults recently diagnosed with ovarian cancer who are scheduled to receive standard chemo drugs (carboplat…

This study looks at how different types of brain training (like adding game elements or coaching) can improve memory and thinking skills in teenagers, including those with ADHD. About 780 teens aged 12-17 will complete 40 training sessions over 4 weeks and take tests before, afte…

This study looks at how training on computer tasks can change the way people think and process information. Researchers will test adults aged 18-30 and 60-85 who have normal vision and no neurological conditions. The goal is to understand how training improves skills like vision,…

This study looks at how being in a hot room affects the body, thinking, and mood of people with schizophrenia. Ten adults with and without the condition will sit in a warm or very hot room for six hours, doing light activity. The goal is to learn how heat impacts them, so better …

This study looks at whether improving deep sleep can help protect against Alzheimer's disease in older adults. Researchers will ask 116 people aged 65-85 with mild sleep issues to slightly reduce time in bed for four weeks to boost deep sleep. They will measure changes in memory,…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking performance in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants complete sho…

This study looks at 65 adults with obstructive sleep apnea to see how three weeks of breathing therapy (ventilotherapy) changes their thinking skills, blood markers linked to brain health, and overall well-being. Participants take thinking tests, give blood samples, and answer qu…

This study aims to find out if keeping indoor temperatures at 26°C (the recommended limit for older adults) can prevent dangerous heat strain and mental decline in children during a simulated heatwave. Ten children aged 10 to 15 will spend six hours in a warm room, doing light ac…

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help reduce the risk of elder fraud.

This study aims to find out if cognitive training (like brain games) can improve memory, attention, and problem-solving. It will enroll 1,600 healthy adults ages 18-30 or 60-85. Participants will complete up to 15 hours of computer-based tasks over 4-8 weeks. This is a research s…