COGNITIVE DECLINE

This study tests whether daily lutein from microalgae can slow age-related mental decline and reduce inflammation in 300 postmenopausal women with belly obesity. Participants will take either 6 mg, 14 mg of lutein, or a placebo for 6 months. Researchers will measure changes in me…

This study tests whether eating foods with resistant starch (a type of fiber) can slow down memory loss in people at high genetic risk for cognitive decline. About 70 adults aged 40 and older with certain risk factors will be randomly assigned to eat either high-resistant starch …

This study looks at whether eating 50 grams of walnuts every day for 24 weeks can improve brain blood flow and insulin sensitivity in adults aged 45-75 with abdominal obesity. Participants will have MRI scans and thinking tests before and after the walnut or no-walnut period. The…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory or thinking problems. Participants will receive six sessions of targeted magnetic pulses over three weeks. Researche…

This study tests whether the antibiotic minocycline can safely stop or reverse thinking and memory problems in adults with sickle cell disease. The drug may reduce brain inflammation that causes cognitive decline. Thirty participants will take either a low dose, high dose, or pla…

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to connect with family. Over six weeks, 40 participants will try the app at home. The goal …

This study tests a community-based program designed to reduce loneliness and social isolation in older adults (60+) living in rural Ecuador. The program includes group activities, peer support, and home coaching. Researchers will measure if it improves heart health, thinking skil…

This study looks at whether heart bypass surgery (CABG) or stents (PCI) cause more long-term memory and thinking problems. Researchers will test 600 adults with computer-based brain games before their procedure and again at 1 month, 1 year, and 2 years after. The goal is to help …

This study tests whether AI-powered fitness trackers and smartphone apps can help older adults (65+) who live alone and have mild memory problems become more physically active. Researchers will track activity levels and well-being over six months in 64 participants. The goal is t…

This study looks at how short bursts of aerobic exercise might help the brain learn and adapt better in older adults and stroke survivors. About 48 participants will do cycling at different intensities, then complete memory and movement tasks while their brain activity is measure…