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Parkinson's study probes blood Pressure's role in brain function

NCT ID NCT06252376

Knowledge-focused Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) using cognitive tests and brain monitoring. However, the study was withdrawn before enrolling any participants, so no results are available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Expected to start

Aug 2025

An estimate. Start dates often move.

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of idiopathic Parkinson's disease (PD) using the Movement Disorders Society (MDS) Clinical Diagnostic Criteria (Postuma, 2015) * Age least 50 years old * Hoehn \& Yahr (H\&Y) stages I to III (early to moderate stage PD) * Proficiency in the English language (native English speaker level) Exclusion Criteria: * Any involuntary movements (i.e., tremor or dyskinesia) greater than 3 cm in amplitude, since the motion artifact can interfere with BP monitor cuff * Taking antihypertensive medications or alpha-adrenergic blocking medications since these can cause hypotension. * Dementia (including PD dementia (Emre, 2007) characterized by either Dementia Rating Scale 2 (DRS-2) score) 124 or less or clinical evidence of impaired instrumental activities of daily living * History of deep brain stimulation (DBS) surgery * Any unstable, active medical problem, e.g., decompensated heart failure, liver failure, etc. * Moderate or severe carotid artery stenosis (according to North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria (Ferguson, 1999) * History of cerebral infarction or hemorrhage * Uncontrolled diabetes or any other systemic disease that causes autonomic failure * Any terminal illness with life expectancy less than 2 years * Illiteracy * Impairment of hearing or vision that is not corrected by devices (e.g., hearing aids or glasses) * Currently pregnant (will be confirmed with a urine pregnancy screening test in people of child-bearing potential) * Any other condition, which, in the opinion of the investigator, could place the participant at increased risk (e.g., substance abuse)

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive change Cognitive decline Cognitive impairment Orthostatic hypertension Parkinson disease

More trials for these conditions

Other studies related to the condition(s) this trial covers.