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Lighter anesthesia may shield seniors from Post-Surgery confusion

NCT ID NCT06268080

Disease control Sponsor: Auckland City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion—and long-term memory problems. About 2,766 participants will be randomly assigned to one of two anesthesia levels, guided by a brain monitor. If effective, this simple change could help millions of seniors stay mentally sharp after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,766 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged ≥ 65 years, and Māori, Pacific or Indigenous participants aged ≥ 55 years who are undergoing major elective or non-elective surgery with expected surgical duration ≥ 2 hours and postoperative hospital stay ≥ 2 nights. * Having general anesthesia using total intravenous anesthesia (TIVA) with pEEG monitoring * Able to provide informed consent (including patients with mild preoperative neurocognitive disorders) Exclusion Criteria: * Intracranial or cardiac surgery * Undergoing surgery with 'wake up' test * Previous enrollment in Balanced-2 study * Terminal illness with expected survival \<3 months * Emergency surgery within 6 hours of presentation to hospital * Cognitive impairment with no capacity to consent or activated enduring power of attorney * Clinically impaired and unable to consent due to acute pathology or preoperative delirium

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Conditions

The condition(s) this trial relates to.

Cognition Disorders cognitive disorder Cognitive Dysfunction delirium Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Cognition disorder Cognitive decline Delirium Delirium, postoperative Surgery--complications

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Auckland City Hospital, Health New Zealand

    RECRUITING

    Grafton, Auckland, 1024, New Zealand

  • Christchurch Hospital

    RECRUITING

    Christchurch, South Island, 4710, New Zealand

  • North Shore Hospital

    NOT_YET_RECRUITING

    Auckland, North Island, 0622, New Zealand

More trials for these conditions

Other studies related to the condition(s) this trial covers.