ANESTHESIA

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium, cognitive decline, and disability. About 2,766 participants will be randomly assigned to one of two an…

This study tests three different approaches given during donor surgery to improve how well a transplanted kidney works afterward. Sixty adults with end-stage kidney disease who are getting a living-donor transplant will take part. The methods include a drug called mannitol, anoth…

This study compares two standard drugs, norepinephrine and phenylephrine, used to treat low blood pressure during major surgery. The goal is to see which one better prevents kidney injury after the operation. About 18,000 adults having non-cardiac surgery lasting at least two hou…

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This study compares two pain management techniques for people having total knee replacement surgery. One group gets a single injection near the knee, while the other gets a continuous pain pump through a small tube. The goal is to see which method reduces the need for opioid pain…

This study compares two methods of calculating propofol (anesthesia) doses for obese patients undergoing surgery. Researchers want to see if using adjusted body weight instead of total body weight leads to safer and more precise anesthesia delivery. The trial involves 46 obese ad…

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each patient's needs can prevent big drops in blood pressure during the start of anesthesia. It involves 320 adults aged 55 and older having planned non-cardiac surgery. The goal is to …

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to improve safety an…

This study compares two methods of pain control after total shoulder replacement: a continuous nerve block catheter versus a single injection of long-lasting medication. About 56 adults having reverse shoulder replacement will be randomly assigned to one of the two groups. The go…

This study tests if the drug Aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either Aprepitant or standard care. The goal is to see if fewer children need extra anti-nausea medication after…

This study tests if a newer sedative, remimazolam, works better than the standard drug propofol for people undergoing endoscopy (a tube camera procedure). The goal is to see which drug provides safer and more comfortable sedation. About 100 adults having planned endoscopy will ta…

This study compares two ways to manage pain after laparoscopic colorectal surgery. One group gets a standard abdominal nerve block, and the other gets that block plus an additional sacral block. The goal is to see if the combined approach reduces pain and the need for strong pain…

This study looks at 100 women having gynecologic surgery to see if a mix of intravenous and inhaled anesthesia helps them recover better than inhaled anesthesia alone. Recovery is measured by a questionnaire about pain, comfort, and daily activities. The goal is to find which met…

This study compares two medications, labetalol and lignocaine, given before a breathing tube is placed during gallbladder surgery. The goal is to see which drug better prevents sudden rises in heart rate and blood pressure, which can be risky. About 116 adults having planned gall…

This study tests if a nerve block called PENG can control pain after hip replacement as well as the standard method of injecting pain medicine into the surgery site. About 60 adults having hip replacement will be randomly assigned to one of the two pain relief methods. Researcher…

This study compares standard spinal anesthesia (bupivacaine) with a version that adds dexmedetomidine for women having planned C-sections. The goal is to see if the combination provides longer pain relief and faster recovery. 300 healthy pregnant women aged 20-35 will take part.

This study compares three medications (dexmedetomidine, fentanyl, and magnesium sulfate) used alongside standard anesthesia for people having brain tumor surgery. The goal is to see which one reduces the total amount of main anesthetic needed and helps patients wake up faster for…

This study looks at whether using epidural anesthesia (numbing the lower chest) instead of general anesthesia (being fully asleep) can improve patient satisfaction and reduce complications during laparoscopic kidney removal. About 80 adults scheduled for this surgery will take pa…

This study compares standard pain relief (IV drugs plus wound numbing) to a combination of two nerve blocks (BAP and TAP) in 140 adults having minimally invasive left-sided colorectal surgery. The goal is to see if the nerve blocks lower pain intensity and reduce the need for opi…

This study tests whether giving methadone as a pill before heart surgery works better than giving it through an IV during surgery to control pain afterward. About 100 adults having planned heart surgery will take part. Researchers will measure how much additional pain medicine pa…

This study tests whether a virtual reality simulation that mimics an MRI scan can help children aged 4-18 stay calm enough to complete the real scan without anesthesia. About 288 children will either use the VR prep, read a booklet, or receive usual care before their MRI. The mai…

This study looks at how different strengths of the numbing medicine ropivacaine affect how fast and how long ankle blocks work for people having bunion surgery. About 174 adults will be randomly assigned to receive one of three concentrations. The goal is to find the best strengt…

This study compares two medications, dexmedetomidine and dexamethasone, added to a standard nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having upper l…

This study looks at two different numbing methods for children getting cavities filled in their back teeth. One method uses a digital device to inject numbing medicine into the bone, while the other uses a manual injection into the gum. The goal is to see which method causes less…

This study tests a new type of nerve block, called a deep rectus sheath block, to see if it reduces pain after laparoscopic gallbladder removal. Sixty adults having this surgery will receive the block, and researchers will measure how much morphine they need in the first 24 hours…

This study tests whether itopride, a drug that helps the stomach empty faster, can reduce the risk of food or liquid staying in the stomach after 8 hours of fasting in people taking semaglutide. The trial involves 60 diabetic patients scheduled for hysterectomy. Researchers will …

This study tests whether interventional radiologists can safely give deep sedation (using ketamine) for procedures that normally require general anesthesia. The goal is to see if this approach works well and is safe, with anesthesiologists on standby if needed. About 40 adults wi…

This study explores whether a non-invasive lung recruitment maneuver can predict if a child under general anesthesia will respond to intravenous fluids. Researchers aim to help anesthesiologists give the right treatment for low blood pressure and avoid unnecessary fluid administr…

This study looks at 120 women having laparoscopic gynecologic surgery (including for cancer) to compare two ways of using the breathing machine: volume-controlled and pressure-controlled ventilation. The goal is to see which method better protects lung function and brain oxygen l…

This study tests a new anesthesia method for heart bypass surgery that aims to be better for the environment, cheaper, and help patients recover faster. About 116 adults having planned bypass surgery will be split into two groups: one gets the new technique, the other gets standa…

This study looks at 110 adults having surgery to see if brain wave patterns and thinking tests can predict how much propofol (a sleep medicine) is needed for deep anesthesia. Researchers will measure brain activity before and during anesthesia. The goal is to understand why peopl…

This study looks at children who had surgery 1-2 years ago to see if using a special brain monitor (pEEG) during anesthesia helped them have fewer behavior problems afterward. Researchers will compare kids who got pEEG-guided anesthesia with those who got standard care. The goal …

This study looks at how often children develop low blood sugar (hypoglycemia) when they fast before surgery. Fasting is required to keep kids safe during anesthesia, but it may cause blood sugar drops, especially in younger children. Researchers will monitor over 6,500 children a…

This study looks at how a low dose of nitrous oxide (laughing gas) affects the brain when people feel pain and form memories. Healthy volunteers will have brain scans while receiving mild pain with or without the gas. The goal is to understand which brain areas are involved, not …

This study explores whether a person's genetic makeup influences their risk of complications during and after surgery, such as nausea, vomiting, heart problems, and pain. Researchers will collect data from 20,000 adults scheduled for surgery to look for links between genes and ou…

This study observes 80 adults with and without diabetes to see how long-term blood sugar control (measured by HbA1c) relates to brain oxygen levels during urologic surgery. Researchers will use a special light-based device (NIRS) to monitor brain oxygen and track recovery. The go…

This study tests a new, compact version of a computer-controlled anesthesia delivery system that automatically adjusts medicine based on brain activity. It involves 150 adults aged 18-65 having non-cardiac surgery lasting at least 60 minutes. The goal is to see if the new system …

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will look at problems like nausea, low blood pressure, and kidney injury. The goal is to improve fasting guidelines for the millions of people who have procedures each y…

This study looks at whether military medics with little intubation experience can safely use the SaCoVLM™ video laryngeal mask airway. It has two parts: training on a simulator and then using the device on sedated patients having elective surgery. The goal is to see how often the…

This study looks at two types of anesthesia—conscious sedation and general anesthesia—used during painless stomach exams (gastroscopy) in frail patients aged 65 and older. The goal is to see which method leads to fewer heart-related problems like irregular heartbeat, blood pressu…

This study explores a new way to measure anesthesia depth by analyzing chemicals in a patient's exhaled breath. Researchers will enroll 500 adults having surgery to see if breath levels of two anesthetics match standard brain-activity monitors. The goal is to develop a non-invasi…

This study aims to count every anesthesia-related activity in Catalonia over 14 days, including surgeries, ICU care, pain management, and deliveries. It includes over 13,000 patients and all anesthesia staff. The goal is to gather data to better plan future resources and staffing…

This study looks at whether how active you are before surgery can help predict your risk of complications or death after the operation. Researchers will track 50,000 adults having planned non-cardiac surgery at two hospitals. The goal is to see if adding physical activity to stan…

This study looks at how small amounts of carbon monoxide (CO) in the blood during anesthesia affect certain proteins linked to inflammation and cell health. Researchers will measure CO levels and three proteins (NF-kB, NRF2, PGC-1α) in 120 adults having surgery. The goal is to un…

This study looks at whether changing the amount of carbon dioxide (CO2) in a child's breath during anesthesia affects how deeply asleep they are. Researchers will measure brain activity in 100 children aged 3-11 undergoing minor procedures. The goal is to see if higher CO2 levels…

This study looks at whether a specific method of removing the breathing tube after abdominal surgery can prevent lung problems like collapsed lungs or pneumonia. It involves 270 adults at moderate or high risk for these complications. The goal is to find the best extubation techn…

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a combination of brain stimulation and EEG can measure brain complexity during sedation without…

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity and brain waves. Researchers will give these drugs to 60 healthy adults and use MRI and EEG to measure effects on memory and pain perception. The goal is to understand how these drug…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung problems after delayed hip surgery in people aged 65 and older. About 40 participants will be assigned to one of the two anesthesia types. The goal is to help doctors choose the safer option f…

This study aims to develop a portable, radiation-free software that uses facial recognition and AI to predict how difficult it will be to place a breathing tube during anesthesia. Researchers will collect facial features and neck movement data from 1,800 adults before surgery to …

This study looks at whether using positive or negative words when describing an epidural procedure changes how much pain a person feels. Researchers will compare pain scores in 30 first-time mothers receiving their first epidural. The goal is to see if careful wording can reduce …

This study follows 2000 adults who are having weight-loss surgery to understand how pain and daily activities change afterward. Researchers will ask patients about their pain, side effects, and ability to do everyday tasks. The goal is to learn what influences pain after surgery,…

This study looks at whether blocking light with an eye shield during general anesthesia changes how much sedative medicine is needed. About 66 adults having surgery will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asleep, a…

This study compares two types of anesthesia—inhaled gas versus intravenous propofol—during surgery for early-stage non-small cell lung cancer. The goal is to see if one method leads to fewer cancer recurrences or deaths. Over 5,000 adults undergoing curative lung removal will be …

This study watches how a standard dose of dexamethasone, a drug often given during surgery, changes blood sugar levels in 100 adults having non-cardiac surgery. Participants wear a continuous glucose monitor for 10 days after surgery, and their blood sugar is also checked with fi…

This study aims to find out how often heart injury occurs after non-cardiac lumbar surgery and what factors increase that risk. Researchers will follow 180 adults undergoing elective lumbar stabilization surgery for 30 days. The goal is to better understand and identify risk fact…

This study is a large registry that will collect information from up to 50,000 people who receive emergency blood transfusions during active bleeding. The goal is to analyze how transfusions affect blood clotting and other key health measures. By understanding these patterns, res…

This study looks at how the body processes anesthetics and painkillers in children and teenagers up to age 18. By measuring drug levels in the blood, researchers hope to find the right doses for safer and more effective pain control. The study is currently recruiting 500 particip…

This study uses brain scans (fMRI) to understand how the sedative remimazolam affects memory, pain perception, and brain activity. About 60 healthy adults will receive the drug and then perform memory tasks while experiencing mild pain. The goal is to learn more about how the dru…

This study tests whether a device called CoreSys can help doctors manage stress during abdominal hysterectomy. The monitor tracks consciousness, pain, and stress levels during surgery. 30 women having the procedure will be split into two groups: one with standard anesthesia care,…

This study tests whether a multilingual AI chatbot called PEAR helps patients understand anesthesia risks better than the usual face-to-face talk with a doctor. About 120 adults having planned surgery will take part. The goal is to see if the chatbot improves understanding and re…

This study aims to understand why some people experience low blood pressure after receiving general anesthesia for surgery. Researchers will monitor heart function and blood flow in 250 adults before and after anesthesia. The goal is to identify key changes that lead to this comm…