Which ventilation mode protects the brain and lungs best during keyhole surgery?
NCT ID NCT06482983
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at 120 women having laparoscopic gynecologic surgery. It compares two ways of using a breathing machine (volume-controlled vs. pressure-controlled ventilation) to see which one better protects lung function and brain oxygen levels during surgery. The goal is to find the safest approach for patients in the head-down position with gas inflation of the abdomen.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors choose the best ventilation method to reduce breathing and brain oxygen risks during laparoscopic gynecologic surgery.
- What could go wrong
- This is a small, early-stage study (120 participants) that only measures short-term effects. Results may not apply to all patients or surgeries.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2023
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-70 age * ASA 1-3 Exclusion Criteria: * Under 18 years of age, over 70 years of age, * ASA IV, * history of severe chronic obstructive pulmonary disease (COPD, GOLD III or IV) ,-history of severe or uncontrolled bronchial asthma, presence of restrictive lung disease, * history of any thoracic surgery operation, need for thoracic drainage before surgery * patients receiving preoperative renal replacement therapy, * congestive heart failure (NYHA grade III or IV), * extremely obese (body Mass Index, BMI \> 35 Kg/m2) * patients without patient consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Umraniye research and education hospital
RECRUITINGIstanbul, Umraniye, 34764, Turkey (Türkiye)
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