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Massive trial aims to settle debate: which common surgery drug saves kidneys?

NCT ID NCT06802224

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two standard blood pressure medications, norepinephrine and phenylephrine, given during major non-cardiac surgery to prevent acute kidney injury. About 18,000 adults having surgery lasting at least two hours will be included. Hospitals will alternate which drug they use each month, and researchers will track kidney and heart outcomes using routine medical data.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine and phenylephrine
What this could lead to
If this trial succeeds, it could identify which standard blood pressure drug is better at preventing kidney and heart complications after major surgery.
What could go wrong
This is a large pragmatic trial, but it compares two already-approved drugs, so the difference may be small. Results may not apply to all surgery types or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 18,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Surgery under general anesthesia with a surgery duration of 2 hours or more * Received intravenous vasopressors during surgery Exclusion Criteria: * Cardiac surgery * Extra-corporeal membrane oxygenation * Organ transplantation * Obstetric procedures * Procedures on the kidney * Outpatient procedures * Already receiving NE or PE or inotropes before induction of anesthesia (at the time of anesthesia start) * American Society of Anesthesiologists physical status classification 5 or 6 * Patient for whom a local protocol recommends a specific first line vasopressor * Most recent documented estimated glomerular filtration rate (eGFR) \< 15 mL/min/1.73m\^2 or preoperative renal replacement therapy within 60 days before surgery * Patients who do not have a preoperative creatinine value within 60 days before surgery * Alive patients who do not have a postoperative creatinine value

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury (AKI) Anesthesia Hypotension during surgery Myocardial injury after noncardiac surgery (MINS) Noncardiac surgery Surgery with general anesthesia Vasopressor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Henry Ford Health

    RECRUITING

    Detroit, Michigan, 48202, United States

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

  • University Health Network

    RECRUITING

    Toronto, Ontario, M5G 2C4, Canada

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

  • University of Maryland

    RECRUITING

    College Park, Maryland, 20742, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98195, United States

  • Wake Forest University School of Medicine

    RECRUITING

    Winston-Salem, North Carolina, 27101, United States

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