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Scientists investigate why older patients need less anesthesia

NCT ID NCT07372417

Knowledge-focused Sponsor: University of Chile Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether inflammation linked to aging affects how much anesthesia older adults need during major abdominal surgery. Researchers will compare younger (18-30) and older (60+) patients by monitoring brain activity, blood markers, and tissue samples. The goal is to understand the connection between immune cells, inflammation, and anesthetic sensitivity, which could improve safety for older surgical patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients from Hospital Clínico Universidad de Chile, in Santiago de Chile, that require elective abdominal surgery and are willing to participate in the study, meeting inclusion criteria and signing the informed consent.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18-30 years or over 60 years old * Scheduled for abdominal surgery * General anesthesia planned with or without spinal anesthesia * Able and willing to provide written informed consent. Exclusion Criteria: * Chemotherapy or systemic corticosteroid use within the past 2 weeks. * Pregnancy. * Active sepsis or systemic infection. * Emergency surgery. * Requirement of ketamine or dexmedetomidine during the first hour of anesthesia. * History or diagnosis of: stroke with persistent neurological deficit, dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, central nervous system autoimmune disorders, systemic autoimmune diseases, or infectious diseases of the central nervous system. * Current treatment with immunomodulatory medications. * Psychiatric disorders with psychotic features. * Use of psychoactive or psychotropic recreational drugs within the week prior to surgery.

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Anesthesia brain monitor Anesthesia depth monitoring Blood-brain barrier permeability Inflammaging Inflammation Inflammation biomarkers Monocyte

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Clínico Universidad de Chile

    Santiago, Santiago Metropolitan, Chile

More trials for these conditions

Other studies related to the condition(s) this trial covers.