INFLAMMATION

This study looks at whether eating grapes every day can improve gut health, reduce inflammation, and help blood vessels work better in overweight adults aged 45 to 70. Participants will drink grape powder or a placebo twice daily for three weeks. Researchers will measure changes …

This study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can help control atherosclerosis…

This study tests whether the anti-inflammatory painkiller ketorolac can improve outcomes for 360 people undergoing emergency surgery for a severe tear in the main artery from the heart (Stanford Type A aortic dissection). Participants receive either ketorolac or a placebo before …

This study tests whether giving a high-protein diet and using mild electrical pulses to stimulate leg muscles soon after a brain bleed can help prevent muscle loss and improve recovery. Researchers will compare these patients to others receiving standard care. The goal is to see …

This study tests whether colchicine, an anti-inflammatory drug used for gout, can reduce the risk of major heart problems and limb complications in people with peripheral artery disease (PAD). About 6,150 adults with symptomatic PAD will take either low-dose colchicine or a place…

This study is testing whether taking propolis and royal jelly supplements for two months can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will measure changes in inflammatory markers from blood samples. The study involves 48 adults with…

This study tests a drug called orticumab in 240 people who have had a heart attack and still have high inflammation in their heart arteries. The goal is to see if orticumab can lower this inflammation better than a placebo over 6 months. Participants will have CT scans to measure…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, thinking skills, and gut bacteria in women aged 20-65 who have prediabetes and are overweight. Participants will take the powder for a set period while researchers…

This study tests whether a comprehensive treatment plan can reduce serious heart events in people with rapidly-progressive coronary artery disease driven by inflammation. Researchers will compare each participant's outcomes before and after treatment. The study enrolls 39 adults …

This study tests whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps. Participants and their household partners will follow a special diet and provide blood and stool samples. The goal is to see if diet can lower …

This study tests whether nattokinase, an enzyme from fermented soy (natto), can reduce inflammation and improve heart health markers in people with high cholesterol. Researchers will give 48 adults either nattokinase or a placebo for two months and measure changes in blood marker…

This study tests a special blood filter (HA380) in 40 very ill adults who need dialysis or a heart-lung machine. The filter is designed to remove harmful inflammatory substances from the blood. Researchers want to see if using the filter is practical and if it can reduce time on …

This study compares two healthy diets—one centered on beef and one following a typical US pattern—to see which better lowers inflammation and improves other health markers in people with metabolic syndrome or pre-diabetes. About 56 adults aged 18-74 with elevated inflammation and…

This study tests whether a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. Half will get the parenting progra…

This study tests whether ziltivekimab, an anti-inflammatory drug, can reduce inflammation in the artery walls of people with heart disease. About 40 adults aged 50 and older with multiple blocked arteries and high inflammation levels will receive either the drug or a placebo. Res…

This study tests whether adding omega-3 fatty acids from fish or plant oils to the diet can reduce inflammation and improve heart health in people at moderate to high risk. About 324 adults over age 55 will take fish oil, camelina oil, or a regular diet for 12 weeks. Researchers …

This study tests whether royal jelly, a substance made by bees, can lower inflammation and oxidative stress in people with high blood pressure. Researchers will give 34 participants royal jelly or a placebo for 8 weeks and measure changes in blood markers. The goal is to see if t…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries and have their blood pressure, artery stiffness, and memory tested. The…

This study tests the drug anakinra in very premature infants (born between 24 and 29 weeks) to find the safest and most effective dose and way to give it (through a vein or under the skin). The goal is to control harmful inflammation that can lead to serious complications. About …

This study tests whether red propolis, a natural bee product, can lower inflammation and oxidative stress in people with chronic kidney disease. Researchers will measure changes in inflammatory markers in 40 patients who are not yet on dialysis. The goal is to see if this supplem…

This study tests whether a special food containing probiotics and prebiotics can help slow or reverse bone loss in older women. About 220 women aged 60 and older will take either the active food or a placebo for 18 months. The main goal is to see if it improves spine bone density…

This study tests whether a ketone supplement can reduce the harmful effects of a high-salt diet in adults aged 60-85. Researchers will measure changes in blood pressure, blood vessel function, and kidney health. The goal is to find a simple way to protect older adults from salt-r…

This study tests if a drug called icosapent ethyl (Vascepa) can reduce inflammation in the arteries of adults hospitalized with community-acquired pneumonia. Inflammation from pneumonia can harm blood vessels, raising heart risks. Over 6 months, 168 participants will take either …

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease to help develop better diagnostic tests. Researchers will compare new test methods with standard ones to see if they are accurate and reliable. The goal is to creat…

This study looks at whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophil count)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires a hospital-based breathing challenge test that is hard to acces…

This study looks at whether measuring inflammation in the breath and blood can help prioritize who gets asthma tests first. About 1,500 people aged 6 and older with suspected asthma will take a simple breath test and a blood test before their regular lung function tests. The goal…

This study tests whether lifestyle changes—like regular exercise, a Mediterranean diet, and cognitive training—can prevent memory and thinking problems in adults aged 50-80 who have depression or depressive symptoms but no current cognitive decline. Researchers will compare three…

This study compares two types of carbohydrates—low-glycemic index (GI) versus standard whole grains—to see which better improves metabolic health in 40 adults with high triglycerides. Participants follow a Mediterranean diet and are monitored for changes in blood sugar, fats, and…

This study looks at whether minocycline, an antibiotic that also fights inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if the approach is practical and acceptable for 35 participants. The goal i…

This study compares two drugs, lidocaine and ketamine, given during colorectal cancer surgery to see which better reduces inflammation (measured by a marker called IL-6). Fifty adults having open surgery will be randomly assigned to receive one of the drugs for 24 hours. The goal…

This study tests whether a low dose of colchicine, a drug used for gout, can improve exercise capacity in people with a type of heart failure called HFpEF who also have signs of inflammation. About 60 participants will receive either colchicine or a placebo for 3 months. Research…

This study tests whether a compound found in green tea, called EGCG, can reduce frailty and inflammation in older adults who have survived cancer. About 118 people aged 65 and older who are pre-frail will take either EGCG or a placebo daily for 12 weeks. Researchers will measure …

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can lower inflammation and pain after major spine surgery. Researchers will measure inflammatory markers and pain scores in 50 adults undergoing long-segment spinal fusion. The goal is t…

This study tests whether a supplement called fucoidan, made from seaweed, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's p…

This study looks at whether drinking haskap berry juice helps reduce inflammation and oxidative stress after an intense leg workout, and whether it helps you regain strength and performance faster. Thirty resistance-trained adults will drink either haskap juice or a placebo and f…

This study looks at two different exercise programs—flexi band resistance training and whole-body electrical muscle stimulation—to see which better helps cancer patients maintain muscle strength, reduce inflammation, and improve quality of life during treatment. About 100 adults …

This study tests whether a higher dose of aerobic exercise, started within two weeks of a concussion, helps teens recover faster. Researchers will measure symptom resolution, brain inflammation markers, and anxiety or depression changes. The goal is to create better rehabilitatio…

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will use the app for 8 weeks, and researchers will track their sleep, mood, fatigue, and signs of inflammation. The goal …

This study tests whether a special type of dynamic lighting can improve sleep, daily rhythms, and overall well-being in frail older adults (over 65) who are in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to see if adjusting l…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study compares a 6-week mindfulness program to a sleep education class to see which better improves sleep in first- and second-year college students. About 240 UCLA students aged 18-22 who have trouble sleeping will participate. Researchers will track sleep quality, inflamma…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. About 40 adults aged 30-60 with a BMI of 30 or higher will be enrolled. Researchers will measure breathing capacity, mus…

This study tests whether supplements made from agar (a seaweed extract) and collagen can reduce knee pain in people with osteoarthritis. Researchers will enroll 80 adults aged 40-70 who have mild to moderate knee pain. Participants will take either the supplement or a placebo for…

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults (60+) who have had lasting cognitive symptoms after COVID-19. 75 participants will either use the brain-training program or do other computer activities for about 6 week…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 veterans will take part. The goal is to see if these treatments help…

This study is looking for ways to predict postoperative delirium—a state of confusion that can happen after surgery—in patients aged 65 and older. Researchers will measure certain substances in the blood before and after surgery to see if they can identify who is at risk. The goa…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels, inflammation, and dietary intake over two years in 70 South African women. The goal is to understand why obes…

This study looks at whether giving mothers in Brazil extra cash each month can protect their children's brain development and mental health. About 450 families with children aged 7-10 will be randomly assigned to receive either $40 or $2 per month for two years. Researchers will …

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, cell energy, and brain waste-clearing function. The goal is to understand how better sleep might support overall …

This study looks at how stress and childhood trauma might increase the risk of preterm birth, especially in Black and Hispanic women. Researchers will study mitochondria, the energy centers of cells, to understand how stress gets "under the skin" and affects pregnancy. The goal i…

This study looks at whether inflammation from e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare vapers and non-vapers, measuring blood vessel responses after giving an anti-inflammatory drug or placebo. The goal is to understand if i…

This study looks at whether using common moisturizers like Vaseline or CeraVe can lower inflammation in adults aged 70 and older with dry skin. Participants will apply a moisturizer daily for 4 weeks and then stop for 4 weeks, acting as their own control. The main goal is to see …

This study aims to better understand the inflammatory genes involved in psoriasis, a chronic skin condition. Researchers will analyze genes like TNF-alpha and IL-6 in 13 adults with psoriasis. The goal is to find better ways to measure and manage the disease, not to test a new tr…

This study looks at whether eating mangoes every day for 4 weeks, instead of high-calorie snacks like cookies and chips, can improve gut health, reduce inflammation, and boost heart health in Hispanic/Latino teens. Researchers will measure changes in blood vessels, gut bacteria b…

This study is observing 150 women scheduled for breast cancer surgery to see if their sleep quality before the operation can predict how much pain and inflammation they will have afterward. Participants will fill out a sleep questionnaire, and researchers will track their pain le…

This study is watching 1,000 ICU patients to find early signs in their bodies that could help doctors diagnose life-threatening conditions like sepsis and ARDS sooner. The goal is to learn which patients might benefit from specific treatments and to discover new therapies. No exp…

This study aims to find genetic factors that may increase the risk of gout, inflammation, and metabolic diseases like diabetes and obesity in people of Polynesian ancestry. Researchers will collect health data and blood samples from 2,750 adults in French Polynesia, including tho…

This study is for 200 adults with overweight or obesity. Researchers want to see if two blood markers of inflammation (SII and SIRI) can help predict metabolic problems like insulin resistance and fatty liver, and how well people respond to weight-loss treatments. Participants wi…

This study watches 80 people with advanced kidney disease who are waiting for a kidney transplant. Researchers will measure heart blood flow and function before and after the transplant to see if the new kidney helps the heart. The goal is to understand how kidney disease and inf…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood of healthy adults aged 35 to 65. These particles help cells talk to each other and may affect heart and brain health. Researchers will compare blood samples …

This study looks at whether measuring CRP levels (a marker of inflammation) and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections. About 1050 adults in Kyrgyzstan will take part. The goal is to see if these tools safely…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure fungal markers and lung health in 100 participants over time. The goal is to better understand why some people with HI…

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study follows 42 adults admitted to the intensive care unit after surgery. Researchers measure inflammation markers in the blood to see if they can predict serious complications or death. The goal is to better understand which patients are at highest risk, not to test a new …

This study is for people with a type of heart disease linked to inflammation. Researchers want to learn about the symptoms, treatments, and health outcomes of 120 participants. The goal is to better understand this condition, not to test a new treatment.

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see which factors—like insulin resistance or inflammation—are linked to changes in memory, proce…

This study measures specific blood markers of inflammation and oxidative stress in 34 adults with Gaucher disease type I. Researchers want to see if these markers can give a clearer picture of disease activity beyond current tests. Participants must be stable on their current the…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain activity in 150 adults living with both HIV and depression. Participants will receive either the therapy or standard care, and researchers will use brain scans and o…

This study collects and analyzes white blood cells from healthy volunteers and patients with autoimmune diseases, inflammation, or liver transplant. The goal is to understand these cells better so researchers can design engineered regulatory T cell (Treg) therapies. The study doe…

This study looks at how long-term marijuana use affects brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure changes in brain health. The goal is to understand the effects, not to test a new treatment. About 220…

This study looks at how difficult childhood experiences and sleep problems might damage blood vessels in young adults aged 18-29. Researchers will track sleep at home and test blood vessel function. Some participants will get a sleep improvement program to see if better sleep hel…

This study is looking at whether early signs in the blood can help doctors identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults to see how well these early markers predict death and organ failure within 28…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc inside cells and how well blood vessels work. The goal is to understand how beef's…

This study tests whether an 8-week online stress reduction program called RiSE can improve well-being, reduce inflammation, and change DNA markers in African American women aged 50-75 who have risk factors for heart or metabolic disease. Participants are randomly assigned to eith…

This study looks at why having low LDL (bad) cholesterol might actually increase the risk of type 2 diabetes. Researchers think LDL entering fat tissue may cause problems that lead to diabetes. They will test if taking omega-3 (fish oil) for 6 months can reduce that risk in 48 ad…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study aims to understand why some people with coronary artery disease get worse quickly due to inflammation. Researchers will compare 20 patients with inflammation-linked rapid disease to 10 patients with standard disease. They will look at medical history, lab tests, and im…

This study looks at platelets (small blood cells) in brain and spinal cord tumors to see if they affect tumor growth and patient survival. Researchers will examine tumor samples from 50 adults undergoing surgery. No new treatment is given; the goal is to learn how platelets inter…

This study looks at why healthy women might be better at calming inflammation than men, which could help explain differences in heart disease risk. Researchers will create small blisters on the skin of 34 volunteers and measure how their bodies respond over 72 hours. The goal is …

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of adults with stable heart disease. Participants must feel stressed and have a history of heart problems. Researchers will use special PET/MRI scans to measure changes in inflam…

This study enrolls people with known or suspected infections or inflammatory conditions to help doctors learn and improve diagnosis. It is not a treatment trial but a way to gather information and train medical staff. Participants will receive standard medical care and may be ref…

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human diseases. Researchers will collect blood, urine, hair, and other samples from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide sa…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study checks if a simple finger prick (dried blood spot) can measure inflammation markers as well as a standard blood draw from a vein. About 50 adults who are getting a vaccine or have a planned stressor will give both types of samples. The goal is to see if the finger-pric…

This study aims to understand how certain immune cells (neutrophils and monocytes) sense signals in the body and what substances they produce, which can lead to inflammation. Healthy adults aged 18-65 who weigh at least 110 pounds can participate by donating blood up to six times…

This study tests whether a device called CoreSys can help doctors manage stress during abdominal hysterectomy. The monitor tracks consciousness, pain, and stress levels during surgery. 30 women having the procedure will be split into two groups: one with standard anesthesia care,…

This study follows 30 women aged 18-70 who are having DIEP flap breast reconstruction after breast cancer surgery. Researchers will take blood samples before and after surgery to measure markers of inflammation and stress. The goal is to learn more about how the body heals and to…

This study looks at whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) at a specific pressure can improve cardiovascular fitness and reduce inflammation in healthy adults. Researchers will measure fitness levels and blood markers of inflammation be…