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Blood markers may flag delirium risk in elderly surgery patients

NCT ID NCT07411612

Knowledge-focused Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is looking at whether certain substances in the blood can help predict postoperative delirium—a state of confusion that can occur after surgery in older adults. Researchers will measure specific biomarkers before and after surgery in 1,170 patients aged 65 and older undergoing major non-cardiac, non-brain, and non-vascular surgery. The goal is to find a reliable way to identify those at risk early, which could improve monitoring and care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify patients at high risk for postoperative delirium using simple blood tests, allowing for earlier monitoring and preventive care.
What could go wrong
This is an observational study, not a treatment trial. It will not test any intervention, and the findings may not lead to immediate changes in patient care. The results are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,170 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients over the age of 65 years undergoing elective major non-cardiac, non-intrcranial, non-vascular surgery

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provide written informed consent * ≥ 65 years of age * Scheduled for elective major non-cardiac, non-intrcranial, non-vascular surgery with estimated time of surgery ≥ 2 hours Exclusion Criteria: * Patients undergoing emergency surgery * History of diagnosed dementia * Language, vision, or hearing impairments that may compromise cognitive assessments * Preoperative delirium * ICU patients undergoing surgery

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Conditions

The condition(s) this trial relates to.

delirium Emergence Delirium Inflammation inflammatory disease Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood brain barrier defect Delirium, postoperative Inflammation Neuronal damage Postoperative complications

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical University of Vienna

    RECRUITING

    Vienna, 1090, Austria

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