INFLAMMATION

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. About 25 participants, at least 3 months post-transplant, will follow a plant-based diet for 16 weeks. Researchers will track c…

This study tests whether a mushroom called Ganoderma lucidum (reishi) can improve antioxidant levels and liver health in 40 adults aged 35-49 with early-stage fatty liver disease. Participants will take the mushroom supplement, and researchers will measure changes in liver functi…

This study looks at whether adding Moringa leaf powder to standard iron pills can improve blood health in pregnant women with iron deficiency anemia. About 59 women in their third trimester will take either Moringa capsules plus iron or iron alone for 60 days. Researchers will me…

This study looks at whether eating 1.5 cups of fresh mango every day for 12 weeks can help control blood sugar, cholesterol, and inflammation in adults with prediabetes. About 31 participants will eat mango for 12 weeks, take a break, then avoid mango for another 12 weeks so rese…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests a monthly injection called ziltivekimab to see if it can lower the chance of heart attacks and strokes in people who already have heart disease, chronic kidney disease, and signs of inflammation. About 6,200 participants will receive either the active drug or a p…

This study looks at whether eating Brazil nuts can lower inflammation and oxidative stress in people with chronic kidney disease (stages 3 to 4). Fifty participants will take Brazil nut supplements and have their blood and stool tested for changes in antioxidants, inflammation ma…

This study tests whether colchicine, an anti-inflammatory medicine, can slow the worsening of aortic valve stenosis—a common heart valve condition. About 150 adults with moderate, symptom-free valve narrowing will take colchicine or a placebo for up to 2 years. The goal is to see…

This study looks at whether eating almonds every day for 12 weeks can help people with metabolic syndrome by improving gut health and lowering inflammation. About 80 adults aged 35-60 with signs of metabolic syndrome will participate. Researchers will measure changes in gut barri…

This study looks at whether certain immune cells (monocytes) can be used as a simple marker to diagnose salt-sensitive high blood pressure. Researchers will test 20 adults with high blood pressure by giving them high and low salt diets and measuring their blood pressure and immun…

This study tests whether a program combining low-dose aspirin, help quitting smoking, diet changes, and more physical activity can reduce inflammation and prevent lung cancer in long-term smokers aged 55 to 75. About 2,000 participants will also get yearly low-dose CT scans for e…

This study tests whether an anti-inflammatory drug called clazakizumab can improve walking speed and reduce disability in older adults. About 29 people aged 70 and older with signs of inflammation and mobility issues will receive either the drug or a placebo every 4 weeks for 24 …

This study tests whether adding the anti-inflammatory drug celecoxib to standard depression treatment helps people with a specific type of depression linked to inflammation and energy-related symptoms like fatigue and weight gain. About 140 adults with this depression subtype wil…

This study tests a culturally tailored mobile health program for 150 Black pregnant women to see if it reduces symptoms of depression, anxiety, and stress. Half of the participants receive the app, which teaches communication and self-advocacy skills and offers a support network.…

This study looks at how a common heart valve procedure called TAVI changes the bacteria living in your gut. Researchers will collect blood and stool samples from 40 older adults before and three months after TAVI to measure bacterial byproducts and identify which bacteria are pre…

This study looks at whether levels of a hormone called prolactin and certain inflammation markers in the blood are linked to how severe Parkinson's disease is. Researchers will measure these in 300 people with Parkinson's and compare them to standard disease severity scores. The …

This study looks at whether a plant-based Mediterranean diet can improve gut health in people who have had colon polyps removed. Researchers will check stool and blood samples over 8 weeks to see if the diet changes gut bacteria and lowers inflammation. The goal is to understand …

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance and weight loss. Researchers will analyze fat samples from 50 people having weight-loss surgery. The goal is to understand why some people with …

This study looks at 45 adults having carotid artery surgery to see if special scans can predict who will have better thinking skills afterward. Researchers check for inflammation in the artery wall and brain, and link it to changes in memory and thinking. The goal is to learn whi…

This study looks at how nutritional counseling and physical exercise affect aging markers in elderly women. Researchers will measure telomere length and other signs of cellular aging in 80 women aged 60-75, some with obesity and some without. The goal is to see if lifestyle chang…

This study aimed to understand how T cells contribute to blood vessel aging and heart disease risk. It planned to give an injection of abatacept to older adults (55-75 years old) and measure changes in artery function. However, the study was withdrawn before enrolling any partici…

This study looks at how an oral typhoid vaccine temporarily changes the gut's barrier, making it more 'leaky,' and how the immune system responds. Ten healthy adults will take the vaccine, and researchers will measure sugar levels in urine and immune cells in blood to track these…

This study looks at how eating fermented and fiber-rich foods during pregnancy changes the gut bacteria of mothers and their babies. Researchers will track 135 pregnant women and their infants to see how diet affects the types of bacteria passed from mother to child. The goal is …

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other problems. Participants give blood, stool, a…

This study looks at 40 people with HIV to see if a common drug called tenofovir causes more immune activation and helps the virus hide in the body. Researchers will compare those on tenofovir-containing treatments to those on other regimens. The goal is to understand how differen…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will follow 505 adults aged 50 and older to see how many experience mental fogginess (called postoperative cognitive dysfunction) up to 4.5 months after surgery. The goal …

This study is collecting information from 800 people with severe aortic stenosis who are scheduled for a TAVI procedure. Researchers want to see if there are differences in heart anatomy and blood test results between people from different countries. The goal is to better underst…

This study looks at how two natural compounds, Taxifolin and Ergothioneine, affect the immune system in healthy adults aged 50 to 65. Participants take these supplements for a period, and researchers measure immune cell activity. The goal is to understand if these dietary compoun…

This study looks at how giving extra amino acids affects protein balance in critically ill patients who are on breathing machines. Researchers will measure protein breakdown and building in the body using special tracers. The goal is to learn more about metabolism, not to provide…

This study was designed to see if taking fish oil before exercise could help reduce inflammation in people with obesity. Researchers planned to measure changes in blood markers and gut bacteria over 6 weeks. However, the study was withdrawn before any participants were enrolled, …

This study looks at whether acetazolamide, a drug used to prevent altitude sickness, can also reduce inflammation and immune system activation caused by high altitude travel. Nineteen healthy adults will take either the drug or a placebo during a short stay at high altitude. The …

This study follows 30 people with mucopolysaccharidoses (MPS) over 3 years to see how their heart and arteries change over time. Researchers use painless ultrasound scans and blood tests to measure artery thickness, stiffness, and signs of inflammation. The goal is to better unde…

This study aims to observe and follow people with inflammatory disorders, such as those caused by infections or immune system problems. Up to 500 participants aged 2 to 80 will receive standard medical care and tests. The main goal is to learn more about these conditions and iden…

This study looks at how different amounts of playing time in preseason friendlies change soccer players' fitness, muscle health, and blood markers. Twenty-four male players will be tested three times over the preseason. The goal is to understand how match exposure affects perform…

This study looks at how eating whole wheat bread changes gut bacteria and health markers in adults with prediabetes. Over two weeks, 65 participants will eat either whole wheat or white bread daily, then provide stool, urine, and blood samples. The goal is to understand how whole…