AGING

This study tests whether a combination of medications and supplements can improve health in people aged 60-80. Participants take either a placebo or one of two treatment mixes for 90 days. The goal is to see if these treatments can boost fitness, thinking, and body composition, a…

This study looks at whether eating wild blueberries can lower blood pressure and improve blood vessel health in men and postmenopausal women aged 45-70 who have slightly high blood pressure. Researchers will measure changes in artery function and stiffness. The goal is to find a …

This study tests whether a low dose of the drug everolimus can safely improve signs of aging in people aged 55 to 80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in metabolism, heart function,…

This study looks at whether taking creatine and HMB supplements, combined with a supervised exercise program, can improve physical function, muscle mass, thinking skills, and quality of life in older adults living in nursing homes who are frail or have muscle loss. Fifty people a…

This study looks at whether specially designed sports exercises can improve balance, physical abilities, and thinking skills in people aged 60 and older. About 140 participants will be randomly placed into either an exercise group or a group that continues their normal routine. T…

This study tests whether a daily calcium alpha-ketoglutarate (CaAKG) supplement can slow biological aging and improve physical health in 30 healthy adults aged 40-75. Participants take either CaAKG or a placebo for 12 weeks. Researchers measure changes in biological age, physical…

This study tests whether a daily pill called MitoQ can improve blood vessel function in adults aged 60 and older. About 112 participants will take either MitoQ or a placebo for 3 months. The goal is to see if MitoQ reduces age-related blood vessel stiffness and damage, which coul…

This study tests three different 12-week programs to help older adults (60+) with type 2 diabetes who live in nursing homes better manage their blood sugar. The programs are: electrical muscle stimulation, supervised exercise (aerobic and resistance), and a health education class…

This study looks at whether using hearing aids over the long term can slow down memory loss and reduce the risk of dementia in older adults. It follows 629 people aged 70-84 who already took part in a previous hearing study. Researchers will compare those who got hearing help rig…

This study tests a combination of three drugs (isatuximab, pomalidomide, and dexamethasone) at lower-than-standard doses in people with multiple myeloma that has returned or not responded to treatment. The goal is to see if this gentler approach is safe and effective for patients…

This study looks at whether reducing the number and dose of medications in people 80 and older can improve their health and independence. Researchers will work with primary care providers to review and safely lower doses of common drugs like those for blood pressure or pain. The …

This study tests whether intermittent doses of fisetin, a compound found in fruits and vegetables, can improve blood vessel function and reduce stiffness in adults aged 65 and older. Researchers aim to see if fisetin works by lowering oxidative stress and clearing aging cells. Th…

This study tests whether 12 months of high-intensity strength training can reduce falls in people aged 80 and older who have sarcopenia (age-related muscle loss). About 241 participants will either do progressive resistance exercises or be in a control group. The goal is to see i…

This early-phase study tests whether a drug called rapamycin can reverse biological aging in 52 healthy adults aged 50 to 80. Participants take the drug for six months, and researchers measure changes in a DNA-based 'aging clock' that estimates biological age. The goal is to see …

This study tests whether a person's own stem cells, taken from fat tissue and returned through an IV, can safely improve quality of life and physical function in people with age-related frailty. About 200 adults aged 40 to 90 who have lost energy and exercise tolerance will take …

This study tests whether adding low, horizontal and vertical lights around bathroom and entry doorframes can help prevent nighttime falls in people with Alzheimer's or related dementias living in assisted living. About 335 residents will take part, and researchers will compare ho…

This study tests whether combining a gentle, noninvasive brain stimulation technique (tACS) with a digital meditation program can improve thinking skills and well-being in adults aged 60-85 with mild cognitive impairment (MCI). About 90 participants will use a meditation app whil…

This study tests a nutritional product called Radicle Clarity™ 25_RAM to see if it can improve cognitive function and reduce brain fog in adults aged 40 and older. Participants take the product or a placebo for 8 weeks and answer surveys about their thinking, fatigue, and sleep. …

This study tests whether a non-invasive brain stimulation technique called RAVANS (a type of vagus nerve stimulation) can improve memory and thinking in older adults. Researchers will measure changes in memory tasks and other cognitive tests. The goal is to see if this safe, expe…

This study tests a home-based digital literacy program for adults aged 65 and older. The goal is to help them better communicate with their healthcare team, manage their health information, and feel more socially connected. Twenty participants will learn to use digital tools in a…

This study tests a simple checklist called CMOT to help ICU teams reduce distress when removing breathing machines from dying patients. About 184 patients and their care teams will take part across four ICUs. The goal is to see if the checklist is practical and improves comfort d…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, balance, and daily living skills in seniors with mental health conditions. About 270 participants living i…

This study looks at whether a 12-week program of functional task training (like standing up from a chair, climbing stairs, and carrying objects) can improve muscle mass, strength, and daily function in older adults with sarcopenia. 30 people aged 60 and older will be randomly ass…

This study tests whether a playful social media game can encourage older women (ages 65-85) to walk more. Participants join a private Facebook group with weekly photo challenges and wear a step tracker. The goal is to see if this fun, social approach boosts daily steps compared t…

This small pilot study tests whether a gentle, non-invasive brain stimulation method (tDCS) can improve thinking, memory, and walking ability in older adults with mild Alzheimer's disease living in supportive housing. Participants receive 10 sessions of either real or sham stimul…

This study compares a new injectable filler, TEOSYAL® TPVM, to an existing one for improving chin shape and lower face aging. About 155 healthy adults with moderate to severe chin retrusion will receive treatment. The goal is to see if the new filler is as safe and effective as t…

This study tests whether a special computer-based brain training program can improve memory and thinking in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo versi…

This study tests a gentle ultrasound treatment aimed at a deep brain area (the hippocampus) to see if it can improve sleep and memory in older adults with early signs of Alzheimer's. Twenty participants aged 60-85 with mild memory issues and poor sleep will receive either real or…

This study looks at whether adding cognitive exercises to physical training can help frail older adults feel better and move better. Forty-five people aged 65 or older who are frail or pre-frail will take part in an 8-week program. They will be split into three groups: one doing …

This study looks at how nutritional counseling and physical exercise affect aging markers in elderly women. Researchers will measure telomere length and other signs of cellular aging in 80 women aged 60-75, some with obesity and some without. The goal is to see if lifestyle chang…

This study aimed to understand how T cells contribute to blood vessel aging and heart disease risk. It planned to give an injection of abatacept to older adults (55-75 years old) and measure changes in artery function. However, the study was withdrawn before enrolling any partici…

This study looks at whether a gentle brain stimulation technique called tDCS can improve how well the brain's networks work together during walking and navigation tasks. Researchers will test 60 older adults with mild memory concerns, giving them either real or fake stimulation w…

This study planned to see if eating blueberries for 12 weeks could improve thinking skills in adults aged 65 and older with mild memory complaints. Participants would have eaten whole blueberries or a powder, compared to a placebo. However, the study was withdrawn before any volu…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults and people with heart disease. Researchers will use ultrasound to see how blood flow changes after a passive leg movement. The goal is to develop a practical tool …

This study looks at how older adults with and without chronic low back pain control their trunk while walking. Researchers will test whether a weekly biofeedback-based training program over four weeks can improve walking patterns and reduce strain on the spine. The goal is to und…

This study tests the safety and biological effects of dietary supplements, like spermidine, in healthy adults aged 18 to 75. Participants take increasing doses over three months while researchers monitor side effects and changes in blood markers. The goal is to gather information…

This study looks at whether a 12-week aerobic exercise program (stationary biking) can improve blood flow and brain function in older veterans aged 65-80 who don't currently exercise. Researchers will measure brain health before and after the program using MRI scans. The goal is …

This study looks at how skin around the eyes changes with age using motion capture technology. Researchers will measure skin movement in 60 healthy women to better understand aging and how treatments like creams or massages might work. The goal is to improve both medical and cosm…

This study looks at whether a personalized brain-training program can help older adults (60+) with high blood pressure who are at risk for memory loss. About 120 people will be split into two groups: one gets the real brain training, the other gets a placebo version. The training…

This study tests whether a sex-specific food supplement can slow biological aging in healthy adults aged 50-70. Over 6 months, 60 participants will take either the supplement or a placebo, and researchers will measure blood markers, body composition, and DNA changes. The goal is …

This study looks at whether a personalized plan of exercise, nutrition, and lifestyle changes can improve muscle strength, immune health, and thinking skills in adults aged 50 to 85. Twenty-five participants will follow their own tailored plan for about three months. The goal is …

This study looks at how a special clinic helps older adults get ready for major abdominal surgery. Researchers will watch and talk to doctors, staff, and patients to understand what works well and what could be better. The goal is to create a plan that other hospitals can use to …

This study looks at how different protein drinks (casein, whey, and soy) affect the body's chemistry in healthy older adults aged 60 to 80. Researchers will measure changes in blood and urine after consumption, along with thinking skills, mood, and appetite. The goal is to gather…

This study follows 75 adults aged 65 and older over three to four flu seasons, giving them a different FDA-approved flu vaccine each year. Researchers collect blood, nasal swab, and stool samples to measure how the immune system responds. The goal is to understand why flu vaccine…

This study looks at how two natural compounds, Taxifolin and Ergothioneine, affect the immune system in healthy adults aged 50 to 65. Participants take these supplements for a period, and researchers measure immune cell activity. The goal is to understand if these dietary compoun…

This study looks at whether doing computer-based brain exercises in the morning or late afternoon helps older adults (60+) recover thinking skills after an ICU stay. Many ICU survivors have trouble with memory and attention, plus disrupted sleep cycles. The goal is to see which t…

This study looks at whether certain mental and physical activities can slow the normal decline that comes with aging. Researchers will follow 400 healthy Malaysian adults aged 60 and older for four years, measuring changes in thinking, brain structure, and other health markers. T…

This study looks back at the medical records of 2,500 people who had thinking and memory tests before and after hyperbaric oxygen therapy (HBOT). The goal is to see if HBOT helps improve cognitive function in patients with traumatic brain injury, stroke, fibromyalgia, or age-rela…

This study is testing whether a 12-week program that combines brain training, social activities, and exercise can help seniors with mental health conditions living in community housing. The program is delivered by a personal support worker and will be adjusted based on feedback f…

This study looks at why being less active harms blood vessels and muscles, especially in people aged 65 to 85. Researchers want to understand the role of oxidative stress in these changes. The goal is to find ways to prevent damage and help older adults recover better after perio…

This study looks at whether taking a special morning and evening food supplement for 6 months can change certain blood markers linked to aging. It involves 60 healthy adults aged 50 to 70. Half take the supplement, half take a placebo. Researchers measure things like blood sugar,…

This study looks at how sleep and daily body rhythms impact memory and brain health in couples over age 50 where one partner has mild memory problems. Researchers will track sleep, daily activities, and thinking skills using smartphones and tests. The goal is to understand how sl…

This study was designed to see how well compounds from a standardized ashwagandha supplement are absorbed in healthy adults aged 65 and older. Researchers planned to measure levels of active ingredients in the blood after taking the supplement. However, the study was withdrawn be…

This study looks at whether older adults who have fallen recently can use a gentle brain stimulation device at home, with help from a caregiver or spouse, to improve their balance and walking. About 72 pairs of older adults and their helpers will be trained and monitored over up …

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty means losing strength and independence. The study will test if this eating pattern h…

This study looks at whether a special health check for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with doctors about age-related concerns during cancer treatment. About 479 patients, caregivers, and clinic staff are takin…

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…