Blueberry powder tested as natural blood pressure aid
NCT ID NCT04530916
First seen Jun 27, 2026 · Last updated Sep 03, 2026 · Updated 2 times
Summary
This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The goal is to see if this simple dietary change can help prevent heart disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- wild blueberry powder
- What this could lead to
- If it works, this could point toward a simple dietary supplement to help manage blood pressure and reduce heart disease risk.
- What could go wrong
- This is an early-phase trial with only 58 participants, so results may not apply widely. The effect may be small or no better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
-
58 people
The number who actually took part.
- Started
-
Jan 2020
- Finished
-
Dec 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
45 to 70 years
- Sex
-
Male participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and postmenopausal women * Aged 45-70 years * Elevated blood pressure or stage 1-Hypertension * Ability to provide informed consent Exclusion Criteria: * Have had a menstrual cycle within the past year * Blood Pressure \< 120 (systolic BP) or ≥ 140/90 mm Hg * Reactive hyperemia index \> 3.00% * Taking \> 1 antihypertensive medication, taking 1 antihypertensive medication more than 1 time per day, and/or taking the antihypertensive medication for \< 3 months * Diagnosed cancer, cardiovascular disease, diabetes, or gastrointestinal, kidney, liver, lung, and/or pancreatic disease * Triglycerides \> 350 mg/dL, low-density lipoprotein cholesterol (LDL-C) ≥ 190 mg/dL, hemoglobin A1c ≥ 6.5%, and/or taking a lipid-lowering or glucose-lowering medication * Testosterone or estrogen replacement therapy use 6 months prior to study start * Weight change ≥ 3 kg in the past 3 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study * Current smokers or history of smoking in the past 12 months * Binge and/or heavy drinker (\>3 drinks on any given occasion and/or \>7 drinks/week for women, and \>4 drinks on any given occasion and/or \>14 drinks/week for men) * Body mass index \< 18.5 or \> 40 kg/m2 * Antibiotic therapy within past two months * Allergies or contraindication to study treatments or procedures
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Food and Nutrition Clinical Research Laboratory
Fort Collins, Colorado, 80523-1571, United States
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