ENDOTHELIAL DYSFUNCTION

This study tests a daily oral supplement designed to boost nitric oxide, a natural chemical that helps blood vessels relax and stay clot-free. As we age, blood vessels can become less efficient, raising the risk of heart disease. The supplement aims to lower levels of PAI-1, a bl…

This early-stage study tests the safety of an experimental drug called EO2002, given as an injection into the eye, for people with corneal edema (swelling of the clear front part of the eye). The study includes 12 adults with corneal swelling caused by Fuchs' dystrophy or a condi…

This study tests whether a drug called galantamine can improve blood vessel function and reduce harmful oxidative stress in African Americans, who face higher risks of heart disease. Researchers will measure changes in blood vessel flexibility and cellular markers of inflammation…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before a brain stent procedure can prevent strokes and keep the stent open. About 354 people with brain aneurysms will receive either atorvastatin or a placebo before their stent surgery and be followed fo…

This study tests a new drug called TB-500 in people with stable heart disease caused by plaque buildup in arteries. The main goal is to check if the drug is safe and tolerable. Researchers will also look at markers of blood vessel health and inflammation. About 80 adults aged 40-…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older with high blood pressure. It compares this quick exercise to the standard…

This study looks at whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. About 40 adults who have used CPAP for over a year will be randomly assigned to use the mouth device o…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device aims to improve sleep quality, which may also reduce the risk of heart disease. Researchers will measure sleep, blood vessel health, and nervous system…

This study looks at whether statins, a common heart medication, affect sex hormones and erectile function in men aged 40-65 who have high or very high cardiovascular risk. Researchers will give 150 men either pitavastatin or rosuvastatin and monitor their erectile function, hormo…

This study looks at whether inflammation from e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare vapers and non-vapers, measuring blood vessel responses after giving an anti-inflammatory drug or placebo. The goal is to understand if i…

This study looks at why women who had gestational diabetes (diabetes during pregnancy) may have higher heart disease risk years later. Researchers will test how a natural chemical called endothelin-1 affects small blood vessel function, and whether physical activity or sitting to…

This study looks at how a specific blood fat called lipoprotein(a) affects the stiffness of arteries, the health of blood vessel linings, and the heart's ability to pump. Researchers will follow 300 adults for one year, measuring these factors and tracking any heart problems. The…

This study looks at how small blood vessels in frail older adults handle the stress of intense exercise. Researchers want to see if a simple technique called ischemic conditioning—using a blood pressure cuff to briefly restrict blood flow—can protect the vessels. Sixty adults age…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will use mild oxygen changes and a placebo to measure responses. The goal is to better understand conditions like sleep apnea, not to treat them directly.

This study looks at how well blood vessels work in men aged 30-50 with erectile dysfunction or low testosterone. Researchers will use a device called EndoPAT to measure vessel function before and 3-6 months after starting daily low-dose ED medication or testosterone therapy. The …

This study looks at why men with spinal cord injury have a higher risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury who have low or normal testosterone levels. The goal is to understand how low testosterone may…

This study looks at how difficult childhood experiences and sleep problems might damage blood vessels in young adults aged 18-29. Researchers will track sleep at home and test blood vessel function. Some participants will get a sleep improvement program to see if better sleep hel…

This study looks at why blood flow in muscles is poor in people with obesity and how exercise might help. Researchers will measure harmful molecules and blood flow in 25 adults before and after an 8-week exercise program. The goal is to understand the body's inner workings, not t…

This study looks at how chemotherapy or radiation before surgery (neoadjuvant therapy) affects small blood vessels and tissue stiffness in colorectal cancer patients. Researchers will compare 34 patients who had pre-surgery treatment with 34 who went straight to surgery. The goal…

This study collects blood and urine samples from healthy volunteers and patients to help researchers study genes, proteins, and other substances. The goal is to develop new lab tests and better understand diseases. Participants must be 18 or older and can join if they have certai…

This study looks at how spinal cord injury (SCI) may damage the cells lining blood vessels, increasing the risk of heart attacks and strokes. Researchers will measure blood vessel function in 40 adults with and without SCI. The goal is to understand the underlying causes so bette…