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Mediterranean diet may boost brain power in seniors, study suggests

NCT ID NCT06192407

Knowledge-focused Sponsor: University of Vermont Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing how two different types of dietary fats affect brain function in healthy adults aged 65 to 75. Participants will follow a low-fat diet for one week, then switch to either a Mediterranean-style diet (high in oleic acid) or a typical North American diet (high in palmitic acid) for another week. The researchers will measure memory and brain activity using MRI scans to see if the type of fat makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High oleic acid diet (Mediterranean-style) and high palmitic acid diet (typical North American-style)
What this could lead to
If it works, this could show that switching to a Mediterranean-style diet improves memory and brain function in older adults.
What could go wrong
This is a small, early-stage study with only 60 participants, so results may not apply to everyone. It only looks at short-term effects over one week per diet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women age range 65-75 years * Normal cognition (see Research Strategy for details on cognitive assessments) * "Healthy" (body mass index (BMI) of 20-40 kg/m2) Exclusion Criteria: * Significant cognitive or behavioral impairment (see Research Strategy for testing and exclusions) or pharmacological treatment for this (e.g. antipsychotics, anxiolytics, and sedative medications). * Hormone replacement therapy, past 3 months. * Hyper-androgenic condition. * HbA1C≥7.5% and or Fasting plasma glucose concentration ≥130 mg/dL. * Type 2 Diabetes if receiving any other therapy than metformin. * Use of nicotine or ingestion of caffeine or alcohol during the study. * Habitual fat intake \< 25% of kcal or strict vegetarian diet. * Sleep apnea requiring continuous positive airway pressure at night. * Lung, cardiac (heart failure or its treatment), liver disease, renal disease, cancer, and any other medical disorder known or thought to cause inflammation or abnormalities of cognition * Actively training for an athletic event or participating in competitive sports (such as league play or tournaments) * Intolerance or allergy to any of the food provided in the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • University of Vermont

    RECRUITING

    Burlington, Vermont, 05401, United States

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