Seaweed pill may turn back biological clock in older men, study suggests.

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 50-80 years males; 2. Resident of Singapore (citizenship or permanent residency is not required); 3. Prefrail according to Fried frailty phenotype score; 4. English-literate who can understand, read and write in English; 5. Individuals without severe cognitive impairment, as determined by PI judgment; 6. Apparently healthy and non-smokers having not more than 2 of the following conditions. If the conditions are present they have to be stable: * Hypertension, * Hyperlipidemia, * Hyperglycemia, * Osteopenia/osteoporosis, * Osteoarthritis, * COPD, * Type 2 diabetes. Subjects who agree to shave one day before each visit if he has dense facial hairs on their cheeks that could interfere with skin microbiome sampling. Exclusion Criteria: 1. Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease); 2. Current cancer or non-stable chronic obstructive pulmonary disease (COPD); 3. Use of anticoagulant medication; 4. Consuming seaweed more than 3 times a week; 5. Having hairiness, moles, tattoos, scars, irritated skin, etc. on the face which could influence the investigation; 6. Having used within the 3 past weeks for more than 3 consecutive days any systemic or topical drugs related to antibiotics or having planned to use these treatments during the study; 7. Having a positive serology for HIV, HEPATITIS B, HEPATITIS C\* \*Subjects will undergo a serology test, which will be conducted at baseline and at the end of the intervention visit. Only for subjects who accepted to undergo skin microbiopsy sampling; 8. Subject with any contra-indication for skin microbiopsies: * hypersensitivity or any serious reaction to local anesthesia; (lidocaine/prilocaine), local antibiotics, and antiseptics, * with inherited or acquired hemostasis disorders, * having had any treatment which may affect the blood coagulation and hemostasis (anti-coagulant medications…), * having a history of wound healing defects (hypertrophic scars, keloids…).