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Your eyes may reveal your Brain's future: new study tests early warning signs

NCT ID NCT06058897

Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study looks at 100 healthy adults over 60 to see if brain scans and eye-tracking tests can predict memory changes. Researchers focus on a small brain area called the locus coeruleus, which is linked to early Alzheimer's changes. Participants will have MRI scans and do computer tasks while their pupils are tracked, with a follow-up after 18 months. No treatment is given; the goal is to better understand aging and find early markers of cognitive decline.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * INSPIRE cohort participant * Mini-Mental State Examination score ≥ 27 on 30 * Access to a web connection from participant's or relative's home and regular use of web surfing * Signature of the informed consent * Affiliated to a social security scheme Exclusion Criteria: * Any contra-indications to MRI exam * Ophthalmic pathology impacting eye-tracking measures * Neurological or psychiatric pathology * Person under guardianship or curatorship Contraindications to MRI examination: * Pacemaker or cardiac defibrillator * Implanted material activated by an electrical, magnetic or mechanical system * Haemostatic clips for intracerebral aneurysms or carotid arteries * Orthopedic implants * Claustrophobia Ophthalmological pathologies impacting eye tracking measurements: * Glaucoma * Age-related macular degeneration * Unoperated cataract

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging

Contacts and locations

Locations

  • University Hospital

    Toulouse, 31059, France

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