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Lettuce extract and exercise: a new recipe for healthy aging?

NCT ID NCT07441343

Symptom relief Sponsor: Dr. Chris McGlory, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This pilot study tests whether taking a daily polyphenol supplement (from red leaf lettuce) alongside a 12-week exercise program can improve physical performance in adults over 60. The main goal is to see if the study is feasible—can people stick with it? Researchers will also measure strength, power, and aerobic capacity. The supplement is thought to reduce inflammation and help muscles recover better from exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Polyphenol-rich extract from red leaf lettuce (Phyto-P)
What this could lead to
If it works, this could point toward a simple supplement strategy to boost the benefits of exercise for older adults, helping maintain strength and independence.
What could go wrong
This is a small, early feasibility study with only 40 participants. It is designed to test whether the study procedures work, not to prove effectiveness. Results may not apply to all older adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Sep 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female or Male * Age \> 60y * Non-Smoking * English Speaking Exclusion Criteria: * Self-reported highly trained individual (training \>3x/week for a specific sport with the goal to compete at a high level) * BMI \< 18.5 * Uses insulin to control blood glucose levels * Any medical, orthopaedic, or psychiatric condition that would be comprise ability to comply with study requirements * Regular user of anti-inflammatory and/or analgesic medication * History of neuromuscular disorder or muscle/bone wasting disease * Determined not ready for exercise by the CSEP GAQ * Use of medication known to affect protein metabolism * Family history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy * Use of anticoagulant medication * Personal or family history of clotting disorder or deep vein thrombosis

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Conditions

The condition(s) this trial relates to.

Frailty Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Frailty Sarcopenia

Contacts and locations

Locations

  • Queen's University School of Kinesiology & Health Studies

    Kingston, Ontario, K7L 3N6, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.