FRAILTY

This study tests whether starting dialysis twice a week instead of the standard three times a week can reduce hospital visits and improve well-being in older adults (60+) with kidney failure who still produce some urine. About 428 participants will be followed for up to 2 years. …

This study tests whether a year-long program combining blueberries, extra protein, and exercise can reduce frailty and lower heart disease risk in older adults. Researchers will enroll 240 people aged 65 and older who are willing to exercise. The goal is to see if this lifestyle …

This study looks at whether repairing a severe leaky heart valve (tricuspid valve) can improve kidney function, reduce swelling, and help older adults move better and feel better. About 100 people who are already scheduled for a valve repair procedure will be followed for a year.…

This study tests whether a multicomponent exercise program can improve physical function, thinking skills, and reduce falls in older adults living in nursing homes. About 60 participants with frailty or dementia will be assigned to either the exercise program or a stretching and …

This study compares a special egg white pudding to a standard nutritional drink (Ensure Plus) in 54 adults with kidney failure who are on dialysis. The goal is to see if the pudding is a practical way to improve nutrition, blood protein levels, and frailty. Participants will rece…

This study tests whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve health in people aged 70 to 85. Researchers believe that restoring gut bacteria may help with aging-related issues like memory, physical function, and inflammation. T…

This study tests a treatment plan that adjusts based on each patient's frailty level for elderly people newly diagnosed with multiple myeloma. The goal is to see if tailoring therapy can improve response rates and reduce treatment side effects. About 131 participants aged 65 and …

This study is testing whether eating protein evenly throughout the day combined with exercise can improve nutrition, muscle mass, and physical function in 90 adults waiting for a liver transplant. Participants are randomly assigned to one of three groups: even protein distributio…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study tests a simple scale that general practitioners can use to spot frailty in independent seniors over 65. Frailty means increased weakness and risk of falls or hospital stays. The goal is to catch it early so doctors can help patients stay healthy longer. About 740 peopl…

This study looks at whether regular, structured health discussions with a healthcare provider can help people aged 67 to 84 stay healthier and live better. About 3,000 participants in Sweden will be followed for six years to track quality of life, hospital visits, and lifestyle c…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in hospitalized heart patients. Frailty makes people more vulnerable to complications and longer hospital stays. The program includes standing, light exercise, and activity tracking. Resea…

This study tests a special home-care program for frail patients aged 65 and older after colon cancer surgery. The program includes diet advice, exercise guidance, and health check-ups at home. Researchers want to see if this extra support helps patients feel better and recover fa…

This study tests a pre-surgery exercise and support program (prehab) for 100 frail or pre-frail adults who need chest surgery. The goal is to see if the program helps patients get stronger before surgery, leading to fewer complications and a faster return home. Researchers will t…

This study tests whether high intensity interval training (HIIT) can reduce frailty and improve resilience in older veterans. Researchers will compare center-based and home-based HIIT programs in 200 veterans aged 65 and older. The goal is to improve physical fitness, thinking sk…

This study tests whether a compound found in green tea, called EGCG, can reduce frailty and inflammation in older adults who have survived cancer. About 118 people aged 65 and older who are pre-frail will take either EGCG or a placebo daily for 12 weeks. Researchers will measure …

This study tests whether a special type of dynamic lighting can improve sleep, daily rhythms, and overall well-being in frail older adults (over 65) who are in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to see if adjusting l…

This study tests whether a program of physical activity, nutritional advice, and psychological support before surgery can improve recovery and quality of life in patients with ovarian or endometrial cancer. 64 participants will be randomly assigned to either receive standard care…

This study tests a strength-based exercise program that seniors can do at home after leaving the hospital. The goal is to help them regain physical function and reduce frailty. Researchers will enroll 256 people aged 60 and older who are at risk of losing independence after a hos…

This study tests whether a program of exercise, nutrition advice, and geriatric care before surgery can help adults aged 65+ with breast cancer maintain physical function and reduce complications. About 90 participants will follow the 8-week program, and researchers will track ch…

This study tests a supplement called EGA® to see if it helps healthy adults aged 60 to 80 exercise longer. Participants will take the supplement or a placebo and measure how long they can cycle before getting tired. The goal is to improve exercise tolerance and understand effects…

This study looks at how common frailty is in older adults with COPD and tests whether the Vivifrail exercise program can improve their physical abilities, daily living skills, and quality of life. About 80 participants aged 60 and older with stable COPD will take part. The progra…

This study tests whether a simple, non-needle ear acupressure technique can help people preparing for major lung surgery feel better and get stronger. Researchers will enroll 40 adults aged 50 and older who are waiting at least two weeks for surgery. Participants will have small …

This study tests a mobile app called SUPERAGING that provides personalized exercise, brain games, nutrition tips, and health management for frail or pre-frail adults aged 60-90. The goal is to see if the app is easy to use and safe, not yet to prove it works. About 40 participant…

This study tests whether a structured care plan, based on patient-reported symptoms, can improve quality of life for adults with advanced cancer. Participants will either receive standard palliative care or a tailored plan that triggers specific support based on their needs. The …

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study explores whether taking a daily polyphenol supplement (natural compounds found in plants) alongside a 12-week exercise program can help older adults build strength and physical function better than exercise alone. Researchers will recruit 40 people over 60 to test if t…

This study looks at whether whole body vibration therapy, when added to usual care, can improve muscle mass, strength, and function in older adults. Forty people aged 65 and older with mild frailty will be randomly assigned to receive vibration therapy plus usual care or usual ca…

This study looks at whether easy-to-do tests for muscle strength and frailty can help predict complications after major abdominal surgery in people aged 65 and older. About 100 participants will complete brief assessments during a routine pre-surgery visit, and researchers will c…

This study tests whether a 12-week personalized nutrition supplement (beta-hydroxy-methylbutyrate) can improve physical function in older adults aged 65-85 with multiple health conditions. The main goal is to see if the study procedures are practical and acceptable for participan…

This study is for adults aged 65 and older in the intensive care unit (ICU). Researchers want to see if three simple measures—the CALLY index (a blood test), a frailty score, and the SOFA-2 score—can better predict who is at risk of dying in the ICU. The goal is to help doctors m…

This study explores whether frailty—a state of increased vulnerability—affects how well patients recover after a code blue (emergency CPR). Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is used. The goal is to better unde…

This study aims to understand if patients who are frail before non-cardiac surgery are more likely to develop acute kidney injury afterward, and whether changes in blood pressure during surgery play a role. Researchers will follow 1000 adults undergoing non-cardiac surgery, compa…

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study follows 150 adults aged 75 and older who receive care in a special emergency unit designed for older patients. Researchers want to see if this unit helps reduce hospital admissions and improves quality of life. Participants are observed over time to track their health …

This study tests whether a 12-week virtual exercise and education program is practical for 30 adults with end-stage kidney disease who are frail and waiting for a kidney transplant. Participants will do home exercises and attend online sessions, with a 5-month follow-up. The goal…

This study is observing 200 older adults (65+) who have hip fracture surgery to see if those who are frail have higher levels of inflammation. Researchers will use simple blood tests taken before surgery to measure inflammation. The goal is to better understand the link between f…

This study looks at whether measuring frailty—how strong or weak a person's overall health is—can improve predictions of death within 90 days after hip fracture surgery. Doctors already use a standard risk score, but it doesn't fully capture physical vulnerability. About 200 olde…

This study looks at 50 adults in the intensive care unit after surgery. Doctors will use ultrasound to measure muscle thickness and fat in the leg, and check nutrition and frailty scores. The goal is to see if these measurements can help predict how long patients need a breathing…

This study watches how sarcopenia (muscle loss) and frailty affect the way a muscle relaxant called rocuronium works in older patients having planned surgery. About 100 people aged 65 and older will take part. The goal is to learn if these conditions change how fast the drug work…

This study looks at whether a new counseling approach based on Canadian 24-hour Movement Guidelines can help physically frail older adults become more active. Researchers will compare this new method to the current one used by physiotherapists. The study involves 20 participants …

This study is enrolling 20,000 adults in Taining County, China, to better understand chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create a bett…

This study looks at whether certain blood markers and brain scans can help predict which older adults with memory loss or frailty will need to visit the emergency room within six months. Researchers will follow 110 participants aged 65 and older who have lost some independence. T…

This study looks at whether being frail before getting sick affects the chance of dying for adults aged 18 to 65 who are in the intensive care unit (ICU) with a severe infection called septic shock. Researchers will measure frailty using a simple scale and track survival for up t…

This study looks at whether a personalized care plan (PCP) for older adults with frailty can be successfully put into practice. Researchers will follow 600 people aged 60 and older for one year to see how many complete their care plan and how well doctors and patients work togeth…

This study will follow 5,000 middle-aged and older Tzu Chi volunteers in Taiwan to see how vegetarian and plant-based diets affect healthy aging. Researchers will measure thinking skills, muscle mass, grip strength, and signs of frailty. The goal is to learn which eating patterns…

This study follows 100 adults admitted to a rehabilitation hospital in the Midwest of Ireland. Researchers will measure how well patients regain independence in daily activities and track their healthcare use after discharge. The goal is to understand what helps or hinders recove…

This study follows 10,000 adults aged 18 and older over many years to see if a set of health measurements can predict how long people live and what diseases they may get. Participants undergo health screenings and are followed until death. The goal is to better understand aging a…

This study aims to help adults aged 60 and older in Singapore stay healthy and independent for as long as possible. Researchers will screen participants in community settings for early signs of decline in areas like memory, mobility, and mood. Those who show early decline will be…

This study is testing whether a monthly monitoring program called ICOPE can help detect early signs of decline in people over 70 with multiple myeloma. The goal is to prevent loss of independence by catching problems early. About 30 participants will use a smartphone app or chatb…

This study aims to find out how common frailty is among people who have received a kidney transplant and whether frailty is linked to long-term kidney function decline. Researchers will assess frailty, nutrition, overall health, and muscle strength in 80 kidney transplant recipie…

This study is observing 500 adults who are having a procedure called left atrial appendage closure (LAAC) to prevent strokes. Researchers want to see how frailty—a measure of weakness and vulnerability—affects their recovery, complications, and quality of life. No new treatment i…

This study follows 250 adults in the intensive care unit (ICU) to learn why some become frail and lose muscle. Researchers will track hospital stays, falls, and readmissions to find factors that can be changed. The goal is to identify targets for future treatments to help patient…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This study looks at whether giving doctors a special geriatric assessment for their elderly patients with type 2 diabetes leads to better treatment decisions. About 220 people aged 60 and older will be randomly assigned to usual care or to have their doctor receive the assessment…