FRAILTY

This study tests a program called INFA, where nurses identify frail older adults (age 65+) in the hospital and create a personalized care plan to address issues like mobility, nutrition, and fall risk. The goal is to help patients maintain their ability to perform daily activitie…

This study looks at whether taking creatine and HMB supplements, combined with a supervised exercise program, can improve physical function, muscle mass, thinking skills, and quality of life in older adults living in nursing homes who are frail or have muscle loss. Fifty people a…

This study looks at whether a combination of exercise, fruit, and vitamin supplements can reduce frailty in older adults aged 65 to 80. About 934 people with low physical activity and low fruit intake will take part. The intervention group will do exercise and eat fruit and vitam…

This study tests whether a special health assessment and personalized care plan can help older adults (65+) starting chemotherapy avoid severe side effects. About 70 participants will either receive the assessment-driven plan plus usual care, or usual care alone. The goal is to s…

This study tests a personalized care model (TIME) for frail older adults receiving home care who are at risk of sudden health crises. About 150 participants will be followed for 6 months to see if the model helps them achieve their personal goals and reduces symptoms like confusi…

This study tests whether a combination of two drugs, dasatinib and quercetin (D+Q), can safely improve physical abilities in people aged 50 and older with HIV who are frail or prefrail. Participants take D+Q or a placebo in short cycles over 12 weeks, then are monitored for anoth…

This study tests two short-term drug combinations (dasatinib plus quercetin, or fisetin alone) in 110 adult survivors of childhood cancer who are frail. The goal is to see if these treatments can reduce signs of cell aging and improve walking speed. The trial is a first step towa…

This study tests whether giving older, frail adults monthly transfusions of blood plasma from young, healthy donors (ages 18-35) can safely reduce frailty and improve immune function. Thirty participants aged 55-95 will receive 12 monthly infusions and be followed for another yea…

This study looks at whether reducing the number and dose of medications in people 80 and older can improve their health and independence. Researchers will work with primary care providers to review and safely lower doses of common drugs like those for blood pressure or pain. The …

This study looks at whether a 12-week exercise program, followed by video-assisted sessions, can improve frailty, mental health, and physical function in 240 adults aged 65 and older living in rural areas. Participants are split into two groups: one does multicomponent exercise (…

This study tests whether a structured home exercise program, delivered via video calls, can reduce frailty and improve daily activity in adults with Fontan circulation. About 53 participants will follow the program for 6 months. The goal is to make exercise training more accessib…

This study tests whether an anti-inflammatory drug called clazakizumab can improve walking speed and reduce disability in older adults. About 29 people aged 70 and older with signs of inflammation and mobility issues will receive either the drug or a placebo every 4 weeks for 24 …

This study looks at whether low-resistance exercise training is safe and can help improve frailty and quality of life in people with pulmonary arterial hypertension (PAH). About 20 adults with stable PAH will take part. Researchers will track safety, how well people stick with th…

This study tests whether a voice-activated app called EngAGE can help frail, homebound older adults (age 60+) with at least two chronic conditions improve their physical function and social connection. Participants use the app at home, and researchers measure changes in chair sta…

This study looks at whether a tailored exercise program before ventral hernia repair can improve recovery in frail patients aged 65 and older. Participants will wear activity monitors and complete surveys about their quality of life. The goal is to see if being more active before…

This study tests a virtual program for teens aged 13-18 with Fontan physiology, a serious heart condition. The program combines group wellness education with a personalized home exercise plan. Researchers want to see if it improves resilience, reduces frailty, and increases daily…

This study compares two walking programs in 60 older adults at risk of frailty. One group aims to replace 30 minutes of sitting with one long walk, the other with three short walks. Researchers want to see which approach is easier to stick with and whether it improves mood, pain,…

This study looks at whether placing a tube through the nose into the stomach (nasogastric tube) helps adults with a small bowel blockage in the emergency department. Researchers will track pain, nausea, hospital stay length, and survival in 400 patients. They will also check if f…

This study looks at why many people with heart failure also lose muscle mass and strength, a condition called sarcopenia. Researchers will measure muscle mass, walking speed, and grip strength, and analyze blood samples from 80 participants aged 50 and older. The goal is to find …

This study tests whether using smartphone apps and sensors can help adults aged 65 and older adopt healthier habits. Researchers will compare two different app-based programs to a simple leaflet. The goal is to see if a larger trial is possible and to gather early data on safety …

This study looks at how a special clinic helps older adults get ready for major abdominal surgery. Researchers will watch and talk to doctors, staff, and patients to understand what works well and what could be better. The goal is to create a plan that other hospitals can use to …

This study gathers feedback from childhood cancer survivors aged 18-39 to improve exercise videos originally made for older adults. The goal is to make the videos more relatable and useful for survivors who are not very active. About 10 participants will share their opinions thro…

This study follows over 19,000 older adults who previously took part in a large aspirin trial. Researchers are monitoring long-term health outcomes like cancer, dementia, heart disease, and disability to see if aspirin has any delayed effects. No new medication is given—participa…

This study looks at whether a program of strength training and reducing sitting time before elective surgery can improve recovery in frail patients aged 50 and older. Researchers will measure walking speed, physical activity, and complications after surgery. The goal is to see if…

This study follows 1,800 adults with chronic kidney disease (not on dialysis) to see how nutrition and lifestyle affect their health over time. Researchers will track heart health, bone health, thinking skills, and daily function using hospital records and a mobile app. The goal …

This study looks at 600 older adults (65+) having major hip or knee surgery to see if a computer model can predict heart injury after surgery. Researchers combine frailty scores, blood tests, and other health data to find who is at highest risk. The goal is to help doctors better…

This study looks at whether a team of specialists working together can improve care for frail veterans before elective surgery. About 35,000 veterans at three VA hospitals will be part of the study. The goal is to see if this team approach lowers the chance of death within 180 da…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty means losing strength and independence. The study will test if this eating pattern h…