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Aspirin's hidden legacy: 19,000 seniors tracked for delayed effects

NCT ID NCT07224347

Knowledge-focused Sponsor: Anne Murray Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could clarify whether taking aspirin has long-term benefits or risks for older adults, especially regarding cancer and dementia.
What could go wrong
This is an observational follow-up, not a new treatment trial. Results may show no clear effects or be limited by the original study's design and participant health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

19,114 people

The number who actually took part.

Started

Jul 2019

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Men and women recruited from the United States and Australia. * African American and Hispanic persons age 65 or older in the U.S. * Any person from another ethnic minority group and Caucasian persons age 70 or older * Willing and able to provide informed consent, and willing to accept the study requirements

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women * African American and Hispanic persons age 65 or older * Any person from another ethnic minority group and Caucasian persons age 70 or older * Willing and able to provide informed consent, and willing to accept the study requirements Exclusion Criteria: * A history of a diagnosed cardiovascular event * A serious intercurrent illness likely to cause death within the next 5 years, such as terminal cancer or obstructive airways disease * A current or recurrent condition with a high risk of major bleeding, ex: cerebral aneurysm * Anemia * Absolute contraindication or allergy to aspirin * Current participation in a clinical trial * Current continuous use of aspirin or other anti-platelet drug or anticoagulant for secondary prevention. People with previous use of aspirin for primary prevention may enter the trial, provided they agree to cease existing use of aspirin and understand that they may be subsequently randomly allocated to low dose aspirin or placebo. * A systolic blood pressure ≥180 mmHg and / or a diastolic blood pressure ≥105 mmHg * A history of dementia * Severe difficulty or an inability to perform any one of the 6 Katz ADLs * Non-compliance to taking pill

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Conditions

The condition(s) this trial relates to.

cancer dementia Depression depressive disorder Frailty heart disorder Hemorrhage hemorrhagic disease neoplasm stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bleeding Cancer Dementia Depression Frailty Functional disability Heart disease Stroke

Contacts and locations

Locations

  • Bendigo Regional Clinical School

    Bendigo, Victoria, 3550, Australia

  • Clinical Trials Unit, The Canberra Hospital

    Garran, Australian Capital Territory, 2605, Australia

  • Discipline of General Practice, School of Population Health, University of Adelaide

    Adelaide, South Australia, 5005, Australia

  • Einstein Medical Center

    Philadelphia, Pennsylvania, 19141, United States

  • Emory/ Atlanta VAMC

    Atlanta, Georgia, 30322, United States

  • Gateway Community Health

    Wodonga, Victoria, 3690, Australia

  • Geelong Hospital

    Geelong, Victoria, 3220, Australia

  • Greater Green Triangle University

    Mount Gambier, South Australia, 5290, Australia

  • HealthPartners Research Institute

    Minneapolis, Minnesota, 55425, United States

  • Howard University

    Washington D.C., District of Columbia, 20060, United States

  • Illawarra Health and Medical Research Institute, University of Wollongong

    Wollongong, New South Wales, 2522, Australia

  • Kent County Memorial Hospital

    Pawtucket, Rhode Island, 02860, United States

  • LSU Health Sciences- Shreveport

    Shreveport, Louisiana, 71130, United States

  • Monash Gippsland Regional Clinical School

    Traralgon, Victoria, 3844, Australia

  • Monash Mildura Regional Clinical School

    Mildura, Victoria, 3500, Australia

  • Morehouse School of Medicine

    Atlanta, Georgia, 30310, United States

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • Phalen Village Clinic

    Saint Paul, Minnesota, 55106, United States

  • Regional Academic Health Center

    Harlingen, Texas, 78550, United States

  • Rush Alzheimer's Disease Center

    Chicago, Illinois, 60612, United States

  • The Brody School of Medicine at East Carolina University

    Greenville, North Carolina, 27834, United States

  • The Menzies Institute for Medical Research, University of Tasmania

    Hobart, Tasmania, 7000, Australia

  • The South West Alliance of Rural Health (SWARH)

    Warrnambool, Victoria, 3280, Australia

  • The University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • UT Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Ballarat

    Mount Helen, Victoria, 3350, Australia

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Pittsburgh Health Sciences Research Center

    Pittsburgh, Pennsylvania, 15260, United States

  • University of Tasmania Newnham Campus

    Launceston, Tasmania, 7250, Australia

  • University of Tasmania Rural Clinical School

    Burnie, Tasmania, 7320, Australia

  • University of Tennessee Health Science Center

    Memphis, Tennessee, 38105, United States

  • University of Texas Medical Branch

    Galveston, Texas, 77555, United States

  • University of Texas Southwestern Medical Center at Dallas

    Dallas, Texas, 75390, United States

  • Wake Forest University Baptist Medical Center

    Greensboro, North Carolina, 27408, United States

  • Wayne State University

    Detroit, Michigan, 48201, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.