BLEEDING

This study looks at whether adding a blood thinner to standard anti-clotting medication can prevent strokes and other blood clots in people who develop a new irregular heartbeat after heart bypass surgery. About 3,200 adults who had bypass surgery and then a lasting or repeated e…

This study looks at 550 adults having a heart procedure through the wrist. It compares giving heparin (a blood thinner) before inserting the tube versus after, to see which timing better prevents blockage of the wrist artery. The goal is to reduce a common complication without in…

This study tests whether finding and treating bleeding early with blood transfusions can lower the risk of delirium (sudden confusion) in people 75 and older with hip fractures. About 198 participants will be randomly assigned to either early treatment or standard care. They will…

This study tests if giving two medicines—tranexamic acid and desmopressin—before surgery can reduce bleeding in people with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see if these…

This study tests if a drug called tranexamic acid (TXA) can reduce blood loss during surgery to remove brain tumors. About 102 adults having a craniotomy will receive either TXA or a placebo during the operation. Researchers will compare blood loss and complications between the t…

This study tests whether cold-stored platelets work as well as standard room temperature-stored platelets to control bleeding in adults having heart surgery. About 150 participants will be randomly assigned to receive one type of platelet transfusion. The goal is to see if a larg…

This study compares two treatments for bleeding after heart surgery: FEIBA (a drug that helps blood clot) versus fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood trans…

This study looks at whether people with advanced heart failure who have a HeartMate3 heart pump can safely stop taking aspirin. The goal is to see if skipping aspirin reduces bleeding problems without increasing the risk of blood clots. About 128 participants who have had the pum…

This study looks at whether giving iron through a vein (IV) can reduce bleeding symptoms in people with inherited bleeding disorders who also have low iron. About 40 participants will receive standard IV iron and be followed for 3 months to see if their bleeding, fatigue, and qua…

This study looks at over 12,000 people with coronary heart disease who take blood thinners. These patients face serious risks of blood clots or major bleeding. Researchers will use advanced tests on blood samples and medical images to find new markers that better predict these ri…

This study looks at 374 older adults with hip fractures who take blood thinners. It compares having surgery within 24 hours versus waiting longer, to see if early surgery leads to more blood transfusions. The goal is to find out if operating sooner is safe and could reduce compli…