BLEEDING

This study tests if a device called the Amulet, which closes a small pouch in the heart, is as safe and effective as daily blood thinner pills for preventing strokes in people with atrial fibrillation. About 2,650 participants will be randomly assigned to get the device or take s…

This study tests whether a point-of-care device (Quantra) that quickly measures blood clotting can guide doctors to give fewer blood transfusions during and after complex heart surgery. About 666 adults having high-risk heart procedures will be randomly assigned to either the dev…

This study looks at whether giving tranexamic acid (TXA) during weight-loss surgery can lower the risk of dangerous bleeding. About 1000 adults having bariatric surgery will either receive TXA or standard care. The goal is to see if TXA reduces the need for blood transfusions, re…

This study tests whether people with atrial fibrillation can take just one blood thinner or aspirin instead of two drugs after getting a WATCHMAN FLX Pro device to close a heart pouch. The goal is to see if these simpler plans are as safe and effective at preventing stroke and ma…

This study tests if a device called WATCHMAN FLX, which closes a small pouch in the heart, is a good alternative to daily blood thinners for preventing strokes in people with a common heart rhythm problem called atrial fibrillation. About 3000 participants are involved. The goal …

This study looks at how well the Amulet device works in everyday medical practice to prevent stroke in people with atrial fibrillation (an irregular heartbeat). Over 600 participants at 16 U.S. sites were followed for 2 years. Researchers tracked complications, device closure suc…

This study tests if a drug called desmopressin can prevent bleeding after a kidney biopsy in people who have had a kidney transplant and are at high risk for bleeding. About 96 participants will receive either the drug or a placebo before the biopsy. The goal is to see if the dru…

This study tests whether 8 weeks of a blood thinner (DOAC) or antiplatelet medication works better to prevent clots on a device placed in the heart's left atrial appendage. The device is used to reduce stroke risk in people with atrial fibrillation. The trial involves 510 adults …

This study looks back at the medical records of 500 people who had surgery on major arteries (not heart surgery). The goal is to see if taking blood thinners (antiplatelet or anticoagulant drugs) around the time of surgery affects the risk of bleeding or blood clots. Researchers …

This study tests whether watching storytelling videos can help African American patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners, which lower stroke risk. About 80 participants will be randomly assigned to view the videos or rece…

This study follows over 19,000 older adults who previously took part in a large aspirin trial. Researchers are monitoring long-term health outcomes like cancer, dementia, heart disease, and disability to see if aspirin has any delayed effects. No new medication is given—participa…

This study was designed to help doctors better manage serious bleeding in patients taking blood thinners. It planned to include 168 adults in Brazil who were on long-term blood thinners and had a major bleed. The study was withdrawn before enrolling anyone, so no results are avai…