DEMENTIA

This study tests whether an oral drug called deferiprone can safely reduce harmful iron buildup in the brain after a bleeding stroke from a ruptured aneurysm. About 66 adult survivors will receive either deferiprone plus standard care or standard care alone for 14 days. The goal …

This study tests a nasal spray called Foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray is designed to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and be follo…

This study tests an experimental drug called DAOIB in 123 people with mild Alzheimer's disease or mild cognitive impairment. Participants take the drug for 24 weeks and have regular blood tests and memory assessments. The goal is to see if certain blood markers can predict who wi…

This study tests whether taking B-vitamins and omega-3 fatty acids together can slow brain aging in older adults at risk for dementia. Researchers will measure a blood marker of brain cell damage and check thinking skills. The study involves 96 people over 65 with low vitamin lev…

This study tests whether a multicomponent exercise program can improve physical function, thinking skills, and reduce falls in older adults living in nursing homes. About 60 participants with frailty or dementia will be assigned to either the exercise program or a stretching and …

This study tests whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and heart problems. About 20,000 participants will be randomly assigned to take either the drug or a placebo pill for several years. The goal is to see if…

This study is testing whether a smartphone app can help diagnose and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by recording and analyzing speech. Researchers will compare speech patterns from 150 people with these conditions t…

This study tests an AI-powered conversation tool called LUMEN that helps caregivers describe a loved one's memory and thinking changes in a structured way. The tool creates clear reports for doctors, which could make dementia assessments faster and more accurate. About 60 caregiv…

This study aims to see if a newer type of brain scan (Tau-PET) can improve doctors' ability to diagnose Alzheimer's disease compared to a standard scan (Amyloid-PET). Researchers will enroll 120 adults aged 50-85 with mild memory or thinking problems. Participants will receive bo…

This study aims to improve early detection of Alzheimer's disease in adults aged 50 and older who live in the community and have no known memory problems. Participants will first complete quick digital tests on a device to check thinking skills and dementia risk. Those with signs…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults, including healthy volunteers and those with memory problems, using a high-sensitivity scanner…

This study tests a simple 5-minute cognitive assessment called 5-Cog to help primary care doctors detect dementia and mild cognitive impairment earlier. It involves 6,600 older adults in 22 clinics in the Bronx and Indiana, focusing on communities that often face health dispariti…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study tests whether investigational drugs can prevent or slow the buildup of harmful proteins in the brain that lead to Alzheimer's. It involves 280 adults who carry a gene mutation that almost guarantees they will develop the disease. The goal is to see if early treatment c…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults who are at risk for dementia and diabetes. One group will do aerobic exercise classes, and the other will get dietary counseling to follow the MIND diet (rich in berries, vegetable…

This study looks at whether regular aerobic exercise can help prevent Alzheimer's disease and related dementias in older adults who are at higher risk. Researchers will enroll 264 inactive men and women aged 50-80 with mild memory concerns but no dementia. Participants will be as…

This study tests a digital program called Exercogs® that combines brain games, physical exercise, and social activities using augmented reality. The goal is to see if it can prevent or slow cognitive decline in adults aged 55 and older who have risk factors for dementia. One hund…

This study looks at whether specific brain-training exercises can help older adults with mild memory problems delay or prevent dementia. About 1,300 people aged 55–89 with mild cognitive impairment will try different combinations of cognitive training or general mental stimulatio…

This study tests a drug called remternetug in 280 people who have a genetic mutation that almost always causes Alzheimer's disease. The goal is to see if the drug can prevent or slow down early brain changes before memory problems begin. Participants will receive either the drug …

This large study in Denmark will give the shingles vaccine (Shingrix) to about 162,000 adults aged 65 and older to see if it also prevents heart attacks, strokes, and dementia. Half will get the vaccine, half will not. Researchers will track health records for several years to co…

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The program aims to reduce caregiver stress, depression, and burden while improving quality of life. About 150 care partners and their loved ones will participate, wi…

This study tests an 18-week program where people with mild dementia and their family caregivers learn sport stacking (quickly stacking and unstacking cups) together. The goal is to see if this fun, at-home activity improves thinking, mood, and quality of life for both. About 144 …

This study tests a learning technique called structured retrieval practice (SRP) to help family caregivers of people with dementia. About 65 caregivers will be randomly assigned to learn caregiving and stress-management strategies using SRP or traditional reading. The goal is to …

This study is testing whether a program using an AI robot can help people with mild to moderate dementia and their caregivers become more physically active. The program is tailored to each pair's needs and aims to improve their physical activity and well-being. The study involves…

This study tests a remote education program called Tele-Savvy for Latino caregivers of loved ones with Alzheimer's or dementia. The program includes weekly group sessions and videos to help caregivers feel more confident and less stressed. Researchers want to see if it improves c…

This study tests a special hearing program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and confusion, and lessen the stress on caregivers. About 300 p…

This study is testing a mobile app called CarePair that helps family caregivers of people with dementia find support services and reduce stress. About 80 caregivers will use the app for six weeks. Researchers want to see if the app is easy to use and if it helps caregivers feel l…

This study explores whether group drumming can help reduce pain and improve well-being in people with early Alzheimer's or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will take part in community drum circles while researchers measure pain…

This study compares treadmill walking alone to treadmill walking while doing mental tasks (like counting or naming) in 46 people with early-to-mid stage Alzheimer's. The goal is to see if the combined training improves both physical movement and thinking skills better than walkin…

This study tests a 16-week exercise program where people with mild dementia and their family caregivers work out together as a team. The goal is to improve thinking skills, mood, and the quality of their relationship. About 236 pairs will join from community centers in Hong Kong.

This study tests whether a low-dose, slow-release form of the drug levetiracetam (AGB101) can reduce overactivity in a key memory region of the brain in healthy older adults. Over 60 participants aged 50–80 will receive both the drug and a placebo in random order for two weeks ea…

This study is testing a mobile app called Care Buddy that helps family caregivers of people with dementia find community services, healthcare advice, and peer support. About 210 caregivers in Singapore will use the app to see if it improves their well-being, reduces stress, and i…

This study tests a personalized home-based activity program for people with mild-to-moderate dementia who have behavioral and psychological symptoms. About 55 participants will receive a tailored activity plan and caregiver training, then follow the program at home for 12 weeks. …

This study tests a program called BrainLive Connect, where trained volunteers lead fun mental activities for people with mild to moderate dementia. The goal is to see if these sessions, held over 7 weeks, can improve thinking skills and quality of life compared to usual care. Res…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—lack of interest or motivation—is common and disabling. The study includes 10 participants, some already taki…

This study tests whether a door-through-door rideshare service, where a trained companion helps participants from their home into the doctor's office, can reduce missed medical appointments for older adults with Alzheimer's or related dementias. About 120 participants will be ran…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with cognitive training can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in two sepa…

This study tests a smart virtual reminiscence therapy (SVR) designed to reduce behavioral and psychological symptoms like agitation, anxiety, and depression in older adults with mild cognitive impairment or early dementia. About 60 participants will use the AI-powered talk therap…

This study tests a 6-week videoconference program that teaches sleep-improving skills to older adults with memory loss or dementia and their care partners. Researchers want to see if the program is practical and helpful for improving sleep. About 80 participants will take part, a…

This study tests an online education and skill-building program for people aged 60+ with early-stage dementia or mild cognitive impairment who live alone. Participants join Zoom sessions to learn ways to reduce stress, improve well-being, and plan for the future. The goal is to s…

This study tests a web-based program called NiteCAPP to improve sleep in 100 rural caregivers of people with dementia. Caregivers with insomnia will use the program and report on sleep, mood, stress, and health over 12 months. The goal is to see if the program helps caregivers sl…

This study tests an online course called CAN-DO designed to help family members and friends who care for someone with dementia. The course teaches skills for navigating healthcare, legal, and financial systems. 270 caregivers will take the course either right away or after a wait…

This study tests if different types of gentle electrical brain stimulation, combined with thinking exercises, can improve memory and thinking in people with dementia. About 100 older adults with mild to moderate dementia will receive either real or fake stimulation to find the be…

This study tests a one-month music program called CoMPoSER, which uses calming, personalized music to help people with dementia sleep better. It also looks at whether the music reduces stress for both the person with dementia and their caregiver. About 144 participants (72 pairs …

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has recently been diagnosed with dementia. The goal is to see if the program is practical and helps reduce emotional distress. The study will involve 50 couples a…

This study explores whether personalized music playlists can help improve behavioral and psychological symptoms in people with dementia. Researchers will create custom playlists based on each person's musical history and observe their responses. The goal is to develop a quick, co…

This study tests whether virtual cycling—pedaling a stationary bike while watching an interactive film—can improve quality of life for older adults with cognitive impairment living in nursing homes. Researchers will compare quality-of-life scores between a group that cycles and a…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study tests whether Jing Si Herbal Tea, taken twice daily, can improve quality of life and sleep for people with dementia and their caregivers. Researchers will first test the tea's feasibility in 100 people with dementia, then run a larger placebo-controlled trial with 200 …

This study tests whether a gentle, non-invasive brain stimulation technique (tES) can improve memory, thinking, and walking in older adults with mild cognitive impairment or mild dementia. Caregivers are trained to deliver the stimulation remotely. The goal is to see if this safe…

This study tests a computerized anxiety sensitivity treatment (CAST) in 388 older adults with mild cognitive impairment or mild Alzheimer's disease and their care partners. Participants attend two treatment sessions and are followed for six months. The goal is to see if CAST redu…

This study tests a transitional care program for people with Alzheimer's or dementia who are leaving a skilled nursing facility to go home, to assisted living, or to long-term care. The program also supports their caregivers. The goal is to see if the program can reduce caregiver…

This study tests a short online program for people who have recently become caregivers for a friend or family member with dementia. The program teaches skills to manage symptoms, find support, and handle medications. Researchers want to see if it helps caregivers feel more in con…

This study is following 10,000 people aged 50 and older living in Scotland over many years. Researchers are collecting information on memory, thinking, lifestyle, and health risks to learn how dementia develops. The goal is to build a detailed picture of the Scottish population t…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study collects blood or saliva samples from people with movement disorders or dementia, along with their family members and healthy volunteers. Researchers will analyze the DNA to find genetic causes of these conditions. The goal is to better understand the diseases, not to …

This registry collects contact info from people interested in Alzheimer's prevention research. Enrollees receive news and emails about studies in their area, such as surveys, lifestyle programs, memory tests, brain scans, or drug trials. Anyone can join online with no obligation …

This study looks at how sleep and exercise habits may affect the risk of dementia in 30 adults who already have memory or concentration problems. Participants will wear a headband and a Fitbit to track sleep and heart health, and provide blood and urine samples. The goal is to un…

This study tests a program called PAIN-CPG-EIT, which helps nursing home staff better assess and manage pain in residents with dementia. Researchers will compare this program to standard education alone across 12 nursing homes, involving 300 residents aged 60 and older. The goal …

This study enrolls up to 550 adults with Down syndrome, ages 25-55, to track their thinking skills, genetics, and brain changes over time. The goal is to understand how Alzheimer's disease develops in this group and to create a pool of volunteers ready for future prevention trial…

This study looks at how the brain works during thinking tasks like remembering or paying attention. Researchers will record brain activity from 30 adults with epilepsy who are already having brain surgery for seizures. The goal is to better understand conditions like dementia, AD…

This study looks at how speaking two languages (Spanish and English or Spanish and Catalan) affects language treatment in people with primary progressive aphasia (PPA), a condition that first causes speech and language problems. Researchers will give tailored speech therapy in bo…

This study looks at how Alzheimer's patients naturally speak and compares it to how dementia is shown in novels. Researchers want to see if fiction matches real-life memory loss patterns. The goal is to create a tool that helps doctors spot dementia earlier and helps caregivers b…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study looks at whether proteins in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will test blood samples from 1,800 older adults and compare them with brain scans and thinking tests. The goal is to develop a simple blo…

This study aims to find the genes that cause Alzheimer's disease by collecting DNA samples from families where two or more members have Alzheimer's or dementia. Researchers will use these samples to better understand the disease and develop new treatments. The study does not offe…

This study aims to create a model that better predicts how different types of dementia will progress over time. Researchers will follow 500 people with early dementia or mild cognitive impairment, using blood tests and thinking assessments. The goal is to improve prognostic confi…

This study aims to scientifically prove whether music therapy has a real effect on Alzheimer's disease. Researchers will measure brain-related molecules (like serotonin and amyloid-beta) in the saliva of 60 older adults—some healthy, some with mild memory problems, and some with …

This study tests whether a special practice method helps dementia caregivers better remember and apply information about managing difficult symptoms. About 60 caregivers will take part in learning sessions and tests immediately and after two days. The goal is to find better ways …

This study tests if a wearable headband that uses sound waves and light can safely monitor blood flow in the brains of people who have had a stroke, as well as those with dementia, depression, or delirium. Researchers will also use artificial intelligence to analyze the data. Abo…

This study looks at whether sleep and body-clock patterns can help predict delirium (sudden confusion) after major orthopedic surgery in adults aged 70 and older. Researchers will track sleep with a watch worn for two weeks before surgery and collect blood samples to check for Al…

This study tests a communication program called COACH-Cog for older adults who have both Alzheimer's or related dementia and cancer. About 300 people (patients, their care partners, and doctors) will take part. The goal is to see if the program helps patients and their families f…

This study aims to see if a quick cognitive test, given during regular check-ups, can help doctors detect early memory problems or dementia in underserved communities. Over 45,000 adults without prior diagnosis will take part across 24 clinics. The goal is to improve early detect…

This study aims to create a large, diverse group of 1,000 older adults (age 60+) to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will have yearly check-ups including memory tests, brain s…

This study follows 1,200 people from two memory clinics in Paris to see if sleep-wake patterns and other personal factors are linked to different types of dementia (like Alzheimer's or Lewy body dementia) and how the disease progresses. Participants will be observed for up to 15 …

This study compares a new approach to managing infections in nursing home residents with dementia against usual care. The goal is to see if the new method reduces antibiotic use and avoids stressful procedures like hospital transfers. About 750 residents aged 60 and older with de…

This study tests a special toolkit designed to help primary care doctors have better conversations about future care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolkit leads…

This study uses special PET scans to measure inflammation in the brains of people with diseases like Alzheimer's, Parkinson's, and ALS, compared to healthy volunteers. Researchers want to see if certain proteins called COX-1 and COX-2 are higher in diseased brains. About 184 adul…

This study tests whether a mobile app called DemensiaKITA can help family caregivers of people with dementia. About 451 caregivers in Malaysia will either use the app or continue with usual support. The goal is to see if the app improves caregivers' knowledge, attitudes, and dail…

This study looks at 300 adults with new memory or thinking problems to see if certain immune system markers (antibodies) are involved. Researchers want to learn how often these antibodies appear and if they can help diagnose a type of dementia caused by the immune system. Partici…

This study looks at the experiences of extended family members—like grandchildren, siblings, and nieces/nephews—who care for a loved one with dementia. Researchers will interview 240 caregivers about their daily tasks, stress, and the support they use or need. The goal is to find…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and how to talk about it with doctors. About…

This study will collect genetic samples and health information from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will link this data to electronic health records to find patterns that could lead to b…

This study looks at whether a tablet-based test called TabCAT can help primary care doctors find early signs of memory loss or dementia in older adults. The test is quick, scores itself, and links to the patient's medical record. Researchers will compare detection rates in 26 Kai…

This study tests a program that sends educational videos and messages through a patient portal to older adults with mild cognitive impairment or dementia and their care partners. The goal is to help them discuss and reduce medications that may be harmful or unnecessary. About 100…

This study aims to create and test a personalized support program for women aged 40-58 going through menopause who have a higher risk of dementia due to a family history. The program will help them manage fears about dementia and learn healthy coping skills. Researchers will firs…

This study follows 10,000 adults aged 18 and older over many years to see if a set of health measurements can predict how long people live and what diseases they may get. Participants undergo health screenings and are followed until death. The goal is to better understand aging a…

This study uses special eye cameras to look for blood vessel changes and protein deposits in the retina of people with Alzheimer's or mild dementia. Researchers will compare these eye scans to those of healthy older adults. The goal is to find a simple, noninvasive way to spot ea…

This study aims to create and improve tests that measure thinking, memory, and social skills in people with brain conditions like dementia or psychiatric disorders. Researchers will test these new tools on 300 healthy volunteers and patients to see how well they work. The goal is…

This study follows 1,000 adults with primary aldosteronism (a hormone disorder that causes high blood pressure) to see how often they develop memory or thinking problems. Participants take regular cognitive tests and health check-ups for up to 5 years. The goal is to understand t…

This study tests a digital tool called CGM ASSIST that helps people with Alzheimer's or dementia and diabetes, along with their caregivers and doctors, better understand blood sugar levels. Participants wear a continuous glucose monitor for 14 days and use easy-to-read displays t…

This study follows 5,000 adults in Hong Kong who either have or are at high risk for brain diseases like stroke and dementia. Researchers will collect medical records, surveys, and phone interviews over many years to identify what factors lead to these conditions. The goal is to …

This study follows nearly 3,000 people, including healthy volunteers and those with memory or movement problems, to track how brain diseases like Alzheimer's and Parkinson's develop over time. Researchers use advanced brain scans and tests to find early signs of disease. The goal…

This study looks at how dementia and mild cognitive impairment (MCI) affect thinking, daily activities, and mood. Researchers will assess 151 adults aged 50-86 to better understand these conditions and improve personalized care. The goal is to gather information, not to test a ne…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study compares two online training programs for staff who care for people with dementia in assisted living facilities. About 1,764 staff and family members will take part to see if the training improves staff knowledge, attitudes, and care practices. The goal is to find the …

This study tests a program called DECLARE that helps caregivers of people with dementia who receive home health care. Caregivers answer a short questionnaire, and their responses are shared with the care team to connect them with a social worker. The goal is to see if this approa…