DEMENTIA

This study tests whether donanemab can slow memory and thinking decline in people with early Alzheimer's disease. About 1,500 participants with mild symptoms and brain amyloid plaques will receive the drug or a placebo for up to 93 weeks. The main goal is to see if donanemab help…

This study tests whether certain drugs can slow memory loss and thinking problems in people who have a genetic mutation that causes Alzheimer's disease. About 490 adults aged 18 to 80 who either know they carry the mutation or are from families with the mutation will receive eith…

This study looks at whether using hearing aids over the long term can slow down memory loss and reduce the risk of dementia in older adults. It follows 629 people aged 70-84 who already took part in a previous hearing study. Researchers will compare those who got hearing help rig…

This study tests whether a drug already used for heart disease, nicorandil, can safely help people with a type of brain aging that looks like Alzheimer's but isn't. It includes 64 adults aged 75 and older who have mild memory problems and signs of hippocampal sclerosis. The main …

This study tests whether a device that delivers light and sound stimulation for 60 minutes each day can slow the decline in memory and daily living skills in people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inac…

This study tests whether deep brain stimulation (DBS) can improve thinking and memory in people with early Alzheimer's disease. Two participants will have electrodes placed in a brain area that produces a key memory chemical. The goal is to see if daily, one-hour stimulation sess…

This study tests the drug lecanemab in 40 people who have a gene mutation that causes early-onset Alzheimer's. The goal is to see if removing amyloid plaques from the brain can delay or slow memory loss and other symptoms. Participants previously received another experimental dru…

This study tests whether changing the dose schedule of donanemab can lower the risk of a brain swelling side effect called ARIA-E while still clearing amyloid plaques. About 1,175 adults with early symptomatic Alzheimer's will receive different dosing regimens over 91 weeks. The …

This study tests whether an experimental drug (E2814) combined with lecanemab can slow Alzheimer's disease in people who carry a genetic mutation that causes it. About 197 adults aged 18-80 with mild or no symptoms will receive either the drug or a placebo for up to 4 years. Rese…

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or frail patients and may be caused by inflammation harming the brain. The trial involves 826…

This study is testing a new, easy-to-use screening tool called ToolBoxDetect that helps doctors find early signs of memory loss or dementia during regular checkups. Over 41,000 adults aged 65 and older from diverse primary care clinics will take a quick computer-based test, and r…

This study is testing a new way to look at brain scans, called Cortical Disarray Measurement (CDM), to see if it can help doctors better diagnose Alzheimer's disease. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results with st…

This study is developing a web application that lets people test their own speech and memory from home. It uses machine learning to analyze speech patterns for early signs of conditions like Alzheimer's or dementia. The goal is to catch cognitive problems early so people can get …

This study looks at whether carefully stopping certain medications (called anticholinergics) can help prevent dementia in older adults. Researchers are following 344 people aged 65 and older who take these drugs, comparing those who get a deprescribing plan with those who receive…

This study tests a website called 'Small Steps' that helps people aged 65 and older make small changes to their daily routines—like sitting less, moving more, and sleeping better—to reduce dementia risk. Participants are split into two groups and use the website for 36 weeks. The…

This study tests whether a special diet called the MIND diet can help prevent memory loss and dementia in people who have had a stroke. Researchers will compare the MIND diet to usual post-stroke care in 250 adults aged 55 and older. The goal is to see if the diet protects the br…

This study is testing whether adding sodium benzoate (a common food preservative) to a gentle brain stimulation technique called tDCS can improve memory and daily function in people with early-stage Alzheimer's or mild cognitive impairment. About 140 participants will receive two…

This study tests whether adding a caregiver training program to a visual mapping app helps both people with dementia and their caregivers. Fifty pairs (a person with mild-to-moderate Alzheimer's or related dementia and their main caregiver) will use the app for 6 months. Half wil…

This study tests a new website tool called WeCareToFeedDysphagia to see if it reduces feelings of burden in caregivers of people with Alzheimer's or related dementias who also have trouble swallowing. About 802 caregivers will either get access to the tool or not, and all will ha…

This study tests whether providing palliative care at home can improve symptom management for people with advanced dementia and reduce stress for their family caregivers. About 150 patient-caregiver pairs in New York City will receive either the in-home care program or standard c…

This study looks at whether a 12-month nurse-led support program can improve symptoms and quality of life for people with mild cognitive impairment or dementia living at home, and reduce stress for their caregivers. About 200 participants from Stanford's Alzheimer's Disease Resea…

This study tests an online Emergency Preparedness Toolkit for caregivers of people with dementia. The toolkit helps caregivers plan for their own unexpected health events by identifying a standby caregiver. About 68 caregivers aged 55 and older who live with and care for a spouse…

This study tests whether a combination of THC and CBD (compounds found in cannabis) can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the study drug or a placebo for 12 weeks. The main goal is to see if agit…

This study tests an online training program for nursing home staff that teaches better communication with residents who have Alzheimer's or other dementias. The goal is to reduce behavioral symptoms like agitation and rejection of care. Over 5,000 staff from nursing homes across …

This study tests a therapy program delivered remotely via a software platform to help reduce anxiety in people with mild cognitive impairment or dementia. About 70 participants will receive the therapy, and researchers will measure changes in anxiety and quality of life. The goal…

This study tests a specially designed garment for elderly people with dementia who have incontinence and often remove their protective pads. The goal is to create a comfortable, dignified romper that reduces agitation and improves care. About 40 patients will try the new garment,…

This study tests a 6-week online program called Learning Skills Together (LST) for family caregivers of people with Alzheimer's or related dementias. The program teaches practical caregiving skills to help caregivers feel more confident and less depressed. 216 caregivers will be …

This study tests a special guide (Swedish Palliative Care Guide) to help nursing home staff provide better care for older adults, including those with dementia. The goal is to make sure residents and their families feel informed and secure about future care. About 400 people livi…

This study tests whether watching 10-minute virtual reality nature videos twice a week for 12 weeks can improve quality of life, mood, and agitation in nursing home residents with dementia. Sixty participants will either receive the virtual nature sessions plus usual care, or usu…

This study tests whether teaching older adults with early-stage dementia to use aromatherapy through augmented reality (AR) can improve their mood and behavior. 300 participants in Taiwan will either receive AR-based aromatherapy education or standard activities. The goal is to s…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study tests a nature-based program led by caregivers for people with mild cognitive impairment or dementia living at home. About 48 pairs (a person with memory issues and their caregiver) will be randomly assigned to either start the program right away or wait. The program i…

This study tests whether adding MK-1167 to standard Alzheimer's medication can improve memory and thinking in people with mild to moderate Alzheimer's dementia. About 350 participants will receive either MK-1167 or a placebo for 24 weeks. The main goals are to see if the drug imp…

This study tests a 12-week coaching program called CuRB-IT for family caregivers of people with dementia. The goal is to help caregivers manage care-resistant behaviors (like refusing help) and improve their own coping skills. 266 caregivers will be randomly assigned to start the…

This study tests a program that focuses on the strengths of people with mild dementia and their family caregivers, rather than their limitations. The program aims to improve thinking skills and make caregiving feel more manageable. About 272 older adults with mild dementia or mil…

This study looks at whether playing motion-based games like Wii or the Magic Table can help older adults with mild to moderate dementia feel more engaged and positive. Twenty participants from a community adult day care will either play these games or do regular activities for 10…

This study tests whether two different essential oil blends can help people with dementia who experience sundowning (agitation in the late afternoon) and poor sleep. About 35 people living in long-term care facilities will try both formulas at different times. The goal is to see …

This study looks at whether joining a community choir can reduce loneliness for people with dementia and their family or friend caregivers. About 100 participants will take part in choir sessions, and researchers will measure changes in loneliness, mood, and well-being over sever…

This study reviews medical records and interviews about 350 caregivers who took part in a telehealth education program for dementia. The goal is to see if the program helped reduce caregiver stress and improve their experience. Researchers will measure things like memory problems…

This study tests whether a web-based education program can improve older adults' knowledge about brain health before surgery. Researchers will measure changes in knowledge scores after 164 participants aged 60 and older complete the online module. The goal is to empower patients …

This study aimed to collect walking data from people with Parkinson's disease, dementia, multiple sclerosis, and other conditions using wearable sensors. The goal was to develop computer programs that could automatically detect walking problems and fall risks. However, the study …

This study looks at blood tests that may help predict Alzheimer's disease and related dementias. Researchers will track changes in these blood markers over time in over 13,000 older adults to see if the patterns differ between men and women. The goal is to create a personalized r…

This study, led by the University of Oxford, is looking at whether blood tests can reliably diagnose dementia in everyday clinics. About 3,165 people aged 45 and older with memory problems will give blood samples and answer questionnaires. The goal is to see if these blood tests …

This study looks at whether people with memory problems will wear digital devices like smartwatches and sleep headbands, and use smartphone apps, to collect health data. Researchers will combine this data with medical records to build computer models that might one day predict de…

This study looks at how often antiepileptic drugs (AEDs) and other psychoactive medications are prescribed in US nursing homes, especially for people with dementia, and how this changed around the COVID-19 pandemic. Researchers will analyze data from over 22 million nursing home …

This study looks at why people with Alzheimer's disease become agitated or aggressive, and tests if a gentle brain stimulation technique called tDCS can help. Researchers will use magnetic pulses and brain wave recordings to understand brain changes in 90 participants, including …

This study looks at how small blood vessel disease in the brain, called cerebral amyloid angiopathy (CAA), may contribute to dementia. Researchers will use special MRI scans to measure blood vessel reactivity in 120 people, including those with early Alzheimer's and healthy volun…

This study uses a special brain scan called DaTSCAN to learn more about aging and diseases like Parkinson's, Alzheimer's, and dementia. Researchers will compare scan results with clinical diagnoses in 500 adults aged 40-90. The goal is to improve understanding and diagnosis of th…

This study looks at whether trained community health workers can help Korean American elders with dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program helps elders get medical care and im…

This study from Stanford University uses cameras and sensors placed in the homes of 25 older adults (65+) to automatically track behaviors like mood changes and agitation. The goal is to see if these tools can help doctors detect and monitor early signs of dementia or other menta…

This study aimed to test a tracking device (Care Companion) for family caregivers of people with dementia who are at risk of wandering. It was planned in two stages: first to see if the device was easy to use, and second to check if it helped reduce caregiver stress. However, the…

This study checks if a translated questionnaire accurately measures knowledge about dementia and urinary incontinence in Turkish older adults. About 230 people aged 55 and older who can read and write will take the survey. The goal is to make sure the questions work well in Turki…

This study follows over 19,000 older adults who previously took part in a large aspirin trial. Researchers are monitoring long-term health outcomes like cancer, dementia, heart disease, and disability to see if aspirin has any delayed effects. No new medication is given—participa…

This study looks at how often and when doctors talk with seriously ill patients about their care wishes. It includes up to 5,000 adults with cancer, heart failure, COPD, or dementia. The goal is to find ways to make these important conversations happen earlier and more often.

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better understand how different d…

This study looks at why some ICU patients develop long-term thinking and memory problems. Researchers are tracking 826 adults who were in the ICU for serious conditions like respiratory failure or shock. The goal is to find risk factors, such as delirium and certain medications, …

This study tests whether training nursing home staff to lead a gentle mind-body exercise program can help older Veterans with dementia maintain their physical function and independence. About 288 Veterans and staff from VA Community Living Centers will take part. The goal is to s…

This study talks to healthcare support workers about their experiences caring for people with dementia who show signs of distress. The goal is to understand what they do and how training could be improved. Six workers from a hospital will share their stories.

This study looks at how live music changes brain activity, heart rate, and anxiety in people with early Alzheimer's or mild cognitive impairment, and their caregivers. Researchers will measure brain waves and heart signals while participants listen to live or recorded music. The …

This study tests a new, highly detailed PET/CT scanner (NeuroEXPLORER) against standard scanners for people with conditions like dementia, Parkinson's, epilepsy, brain tumors, and head/neck cancers. About 1,600 participants will get both scans in one visit to see if the new scann…

This study looks at whether eating nuts is linked to a lower risk of diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine data from over 1 million adults worldwide to get clearer answers. The goal is to understand if nuts can help prevent these co…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that may lead to thinking problems in CKD patients. Participan…

This study asks 1,000 people with neurological diseases (like Alzheimer's or Parkinson's) and their caregivers to share their experiences using a head device called MemorEM. The goal is to learn how to improve the device's design and make it easier to use in future studies. No tr…

This early-stage study tests whether a daily pill called MIB-626 can enter the brain and affect aging-related pathways in people with mild Alzheimer's disease. Researchers will measure the drug and its byproducts in spinal fluid and use advanced brain scans to see if it boosts NA…

This study looks at whether training volunteers to visit older adults with memory loss or dementia can improve the volunteers' skills and reduce loneliness in the people they visit. About 342 volunteers and clients in Minnesota are taking part. The training is part of the volunte…

This study looks at whether a virtual reality (VR) education program can improve nursing students' attitudes and knowledge about dementia. About 200 Indonesian nursing students will take part in a single 100-minute class that includes VR experiences and discussions. The goal is t…

This study will enroll 100,000 adults aged 45 and older to track early signs of Alzheimer's and Parkinson's disease using phone apps, voice recordings, and movement tests. Researchers aim to create better tools for early diagnosis by combining digital data with genetic and biolog…

This long-term study follows 1,500 adults with normal memory, mild cognitive impairment, or Alzheimer's disease. Researchers use brain scans, memory tests, and genetic data to understand how the disease progresses and to improve future clinical trials. The study also aims to incl…

This study looks at whether an interactive virtual reality (VR) game can help nursing students learn about dementia. About 200 Indonesian nursing students will take part in a 30-minute class that includes role-playing with an AI character who has dementia. Researchers will measur…