Could an Iron-Removing pill protect the brain after a burst aneurysm?
NCT ID NCT03754725
First seen Nov 06, 2025 · Last updated Jun 23, 2026 · Updated 39 times
Summary
This study tests whether the drug deferiprone can safely lower iron levels in the brain after a bleeding aneurysm. About 66 adults who had a ruptured aneurysm will receive either deferiprone or a placebo for 14 days. Researchers will measure iron in spinal fluid, brain MRI scans, and memory tests to see if the drug helps prevent cognitive decline.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University Health System
RECRUITINGDurham, North Carolina, 27710, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Univesity of Iowa Hospital and Clinics
ACTIVE_NOT_RECRUITINGIowa City, Iowa, 52242, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Deferiprone (oral pill)
What this could lead to
If it works, this could point toward a treatment that reduces brain damage and memory loss after a bleeding aneurysm.
What could go wrong
This is an early Phase 1/2a trial with only 66 people, so it is too small to prove effectiveness. The drug may not reduce iron enough or could have side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.