Heart disorder

Researchers are testing XC001, an experimental gene therapy, in people with refractory angina, a type of chest pain caused by blocked heart arteries that persists despite medication and is not suitable for surgery or stenting. The trial delivers XC001 directly into the heart musc…

This phase 2 trial tests whether a single dose of LX2006 gene therapy can improve heart muscle thickening and damage in people with Friedreich ataxia, a genetic disorder that often leads to life-threatening cardiomyopathy. Participants aged 6 and older with confirmed heart enlarg…

This study is testing a new, wire-free pacemaker called LivIQ in 325 people who need a pacemaker for a slow heartbeat. The goal is to see if it is safe and works well to keep the heart beating at the right pace. Participants will be followed for several months to check the device…

This study follows 335 adults with severe eosinophilic asthma who are taking benralizumab. Researchers want to see if the drug helps patients achieve partial or complete clinical remission—meaning fewer symptoms, no need for steroid pills, and better lung function—over 12 to 24 m…

Researchers compare two procedures for people with persistent atrial fibrillation that has not responded to at least one antiarrhythmic drug. One group receives standard catheter ablation, which burns or freezes small areas inside the heart. The other receives a hybrid procedure …

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study looks at whether combining a heart procedure called ablation with a 12-week home exercise program can improve how well the body uses oxygen in people with a type of heart failure (HFpEF) and a common heart rhythm problem (atrial fibrillation). About 40 participants wil…

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This early study tests a robotic catheter system to replace the tricuspid valve in 10 patients with severe leakage (regurgitation) who are too high-risk for open surgery. The robot aims to improve precision and safety while reducing radiation exposure for doctors. The main goal i…

Researchers are studying the SPIKE FLOW endocardial lead, a temporary wire placed inside the heart to keep it beating during surgery or while doctors check a slow heart rhythm. The study enrolls 131 adults who need short-term cardiac pacing. Doctors implant the lead, measure how …

Researchers compare empagliflozin and dapagliflozin, two similar diabetes drugs, to see which works better at preventing death, heart problems, and kidney damage in adults with type 2 diabetes, heart failure, or chronic kidney disease. The trial uses electronic health records to …

This study tests a new device (Sphere-9 catheter and Affera system) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in 260 adults who have had a heart attack. Participants must have had repeated episodes despite medication or a defibrillator. The goal is to see …

This trial tests an investigational medicine called ATR 1072 in adults with PRKAG2 syndrome, a genetic condition that causes abnormal heart muscle thickening and rhythm problems. The drug is designed to reduce the activity of the faulty PRKAG2 gene. Researchers are evaluating its…

This study compares newer blood thinners (DOACs) to the standard drug warfarin in patients who need anticoagulation after open-heart surgery. About 3500 adults with atrial fibrillation will be randomly assigned to receive either a DOAC or warfarin for 30 days. The main goal is to…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This study tests a daily injection called elamipretide in 48 people with genetically confirmed Barth syndrome, a rare condition that causes muscle weakness and heart problems. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see if the drug…

Researchers compare two ways of using a leg vein as a second bypass graft during coronary artery bypass grafting. In one method, the vein connects as a Y-shaped branch off the left internal thoracic artery. In the other, the vein connects directly from the aorta. The trial enroll…

Researchers are testing whether adding bempedoic acid to high-intensity statin and ezetimibe therapy within 72 hours after a heart procedure helps adults with acute coronary syndrome reach very low LDL cholesterol. Participants receive either the three-drug combination or the sta…

This study tests whether a personalized blood-thinner plan can reduce bleeding in people with coronary artery disease who have received a heart stent. About 3,944 participants will either get the usual dual antiplatelet therapy (two blood thinners) or a shorter course followed by…

This study tests whether a personalized blood transfusion approach, based on oxygen levels, is better than the standard method for people on a heart-lung machine (ECMO) due to severe heart failure. About 236 adults will be randomly assigned to one of two strategies to see which r…

This study tests a new, less invasive way to replace a leaky aortic heart valve (aortic regurgitation) using a device called the JenaValve Trilogy, compared to standard open-heart surgery. About 1,000 people with moderate to severe aortic regurgitation will be randomly assigned t…

This trial tests whether cooling patients to 33°C (therapeutic hypothermia) improves survival and brain function compared to keeping them at normal body temperature after an in-hospital cardiac arrest. About 788 comatose adults who had a cardiac arrest in the hospital will be ran…

This study tests a new device called the RevCore Thrombectomy Catheter to treat blocked stents in the leg veins. About 100 adults with stents that have been in place for at least 6 weeks will be enrolled. The device is inserted into the vein to remove the blockage and restore blo…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests a new device that creates a small passage in the heart to relieve pressure, without leaving a permanent implant. It is for 350 people with heart failure and reduced pumping ability. The goal is to see if it reduces deaths, need for a heart pump or transplant, and…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This study tests a new device called the Elevate™ heart pump in 290 people who need high-risk angioplasty (a procedure to open blocked heart arteries). The pump helps keep blood flowing during the procedure. The goal is to see if it is safer and works better than current methods.…

This Phase 3 study tests a drug called nucresiran in 1250 people with ATTR amyloidosis, a rare disease where abnormal proteins damage the heart. Participants receive either nucresiran or a placebo every 6 months. The goal is to see if the drug reduces deaths and heart-related hos…

This phase 3 trial tests whether maridebart cafraglutide (MariTide) can reduce heart failure events like hospitalizations and urgent visits in people with obesity and a specific type of heart failure (preserved or mildly reduced ejection fraction). About 5,056 participants will r…

This trial tests whether fexofenadine, a common allergy medication, can help the heart heal better after a severe type of heart attack called STEMI. Participants will receive either fexofenadine or a placebo for six months, alongside standard care, after undergoing a procedure to…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

Researchers are testing a small implantable device called an atrial shunt in adults with heart failure and reduced ejection fraction. The device creates a passage between the upper chambers of the heart to redirect blood flow and may ease symptoms. The trial compares the shunt pl…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This study tests a new device called the SpherePVI catheter, which uses heat to isolate the veins that trigger atrial fibrillation. About 100 adults with symptomatic AF who haven't responded to medication will be enrolled. The main goals are to see if the procedure is safe and ca…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests whether giving two medicines (acetaminophen and ibuprofen) together works better than ibuprofen alone to close a common heart blood vessel in extremely premature infants (born before 27 weeks). About 310 babies will take part. The goal is to see if the combo redu…

This study tests a new catheter system called SpherePVI that uses heat to destroy tiny areas of heart tissue causing atrial fibrillation (an irregular heartbeat). About 150 people with symptomatic atrial fibrillation will undergo the procedure. The goal is to see if the device ca…

This study tests a new device to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve) who cannot have standard surgery or a less invasive repair. About 1,056 participants will receive the device and be followed for safety and quality of life. …

This study follows 500 adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a progressive heart condition caused by abnormal protein buildup. Participants take acoramidis as part of their usual care, and researchers collect data from hospitals and a European registry. The …

This study tests a special stent designed to keep a small heart vessel open in babies under 6 months old who have a congenital heart defect. The goal is to improve blood flow to the lungs and delay or avoid open-heart surgery. About 35 infants will receive the stent and be monito…

This study tests a device called the Edwards PASCAL System, which is threaded through a blood vessel to repair a leaky tricuspid valve in the heart. It is for people with severe symptoms who are not good candidates for open-heart surgery. About 1,270 participants will be randomly…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

Researchers are testing whether a balloon catheter coated with the drug sirolimus can safely open narrowed coronary arteries in adults with heart disease. The balloon inflates to press the drug into the artery wall, aiming to keep the vessel open without leaving a permanent stent…

Researchers are testing whether reducing alcohol intake after catheter ablation helps people with atrial fibrillation. The trial enrolls 184 patients who regularly drink more than five alcoholic drinks per week and are scheduled for their first ablation. Participants are asked to…

This early-stage trial tests a new antibody drug called procizumab in 130 people with cardiogenic shock, a life-threatening condition where the heart cannot pump enough blood. The drug blocks a protein called DPP3, which is linked to worse outcomes. The main goal is to check safe…

This study tests whether special force feedback instruments, used with the da Vinci surgical robot, can safely and effectively repair leaky mitral valves. The trial includes 30 adults with moderate-to-severe mitral regurgitation. Researchers will check for major complications and…

This trial tests a procedure called TEER, which uses a clip to repair a leaky heart valve (mitral regurgitation) caused by an irregular heartbeat (atrial fibrillation). The study will include 400 people with moderate-to-severe or severe leakage who still have symptoms despite tak…

This study tests a new device called the Cephea Mitral Valve System for people with a leaky or narrowed mitral heart valve. The goal is to see if it is safe and works well for patients who are not good candidates for open-heart surgery. About 50 people will get the device and be …

This study is testing a long version of the Ultimaster Nagomi stent in people with long blockages in their heart arteries. About 1,039 participants will receive the stent and be followed for one year to see if it works well and stays safe. The goal is to see if one long stent can…

This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medic…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests a device called Barostim that stimulates nerves in the neck to help the heart work better. It involves 2,500 adults with moderate heart failure who still have symptoms despite standard treatments. The goal is to see if the device reduces deaths and hospital stays…

This Phase 3 trial is testing whether a combination of two drugs, balcinrenone and dapagliflozin, works better than dapagliflozin alone to prevent heart failure events and cardiovascular death. About 4,800 adults with heart failure and moderate-to-severe kidney impairment who rec…

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

Researchers compare two imaging strategies for planning left atrial appendage closure in adults with nonvalvular atrial fibrillation. Participants are randomly assigned to have their heart anatomy assessed either by transesophageal echocardiography or by cardiac CT angiography be…

This phase 3 trial investigates whether starting a combination of finerenone and empagliflozin early during a hospital stay for heart failure can improve outcomes compared to usual care. About 1,500 adults hospitalized with heart failure will be enrolled. The study measures effec…

This study tests whether switching from tafamidis to acoramidis can raise blood levels of transthyretin (TTR) in adults with transthyretin amyloid cardiomyopathy (ATTR-CM). The drug acoramidis stabilizes TTR to prevent harmful amyloid clumps that stiffen the heart. Researchers wi…

Researchers at one hospital are observing 400 people with arteriosclerosis obliterans, a condition where plaque blocks arteries in the legs. The study compares four common procedures: bypass surgery, bare metal stents, plain balloon angioplasty, and drug-coated balloons. Over thr…

Heart failure is the leading cause of heart-related hospital admissions in Ghana, and many patients return to hospital soon after discharge. This pilot trial tests whether extra counselling from a study doctor, pharmacist, or nurse, plus weekly phone follow-up calls for the first…

This study compares a new temporary heart pump called the Supira System to the existing Impella pump in 358 patients undergoing high-risk coronary stenting. The goal is to see if Supira is as safe and effective at supporting the heart during the procedure. Participants are random…

This early-stage trial is testing an experimental drug called HJB647 in 12 adults with stable chronic heart failure and reduced pumping ability. The study aims to check the drug's safety and how the body processes it at two different doses. Participants will receive both the drug…

This study tests whether the drug finerenone can reduce hospitalizations and deaths in people with a certain type of heart failure (with preserved or mildly reduced pumping ability). About 5,200 adults who are currently or recently hospitalized for heart failure will receive eith…

This study tests whether the drug CardiolRx can prevent another episode of pericarditis (inflammation around the heart) in people who have had repeated attacks. About 110 adults who have been stable on an IL-1 blocker for at least a year will stop that medication and receive eith…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either ele…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study tests whether a drug called Brezavvy (an SGLT2 inhibitor) can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked major arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo hea…

This study tests a new device that uses electrical pulses to treat atrial fibrillation (an irregular heartbeat) while patients undergo other heart surgery. About 135 adults aged 18-85 with a history of AFib will participate. The goal is to see if the device safely restores normal…

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

After an out-of-hospital cardiac arrest, doctors often aim to keep mean arterial pressure at or above 65 mmHg, but no one knows the best target. The METAPHORE trial compares a standard target of 65 mmHg with a higher target of 90 mmHg for the first 24 hours, using norepinephrine …

This study tests whether early heart screening and treatment for iron overload in people with sickle cell disease can prevent heart problems and reduce hospital stays. About 100 adults with sickle cell disease and high iron levels will receive regular heart imaging and follow-up …

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

Researchers are testing whether manually removing blood clots from a blocked heart artery during emergency angioplasty helps people who have a severe heart attack with a large clot burden. The trial enrolls adults treated within 12 hours of symptom onset whose angiogram shows a h…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This trial studies whether removing blood clots from heart arteries during angioplasty improves outcomes for people who have had a major heart attack. 3500 participants will be randomly assigned to get either clot removal plus angioplasty or angioplasty alone. The main goal is to…

This study tests an experimental drug called VTX2735 in 50 adults with recurrent pericarditis, a condition where the heart's lining becomes inflamed and painful. The goal is to see if the drug is safe and can reduce pain and inflammation. Participants receive different doses over…

This study tests whether a device called Bioboosti, which delivers pulsed electromagnetic fields, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow during stress and track symptoms like chest pain and exercise capacity…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 600 minority patients with coronary artery disease. The goal is to see which approach leads to better survival and quality of life. Participants will be followed over time to track outcome…

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted for heart failure will be randomly assigned to either…

This trial tests whether a monitor that measures muscle response can guide the dose of the muscle relaxant atracurium in intensive care unit patients who need a continuous drip for more than 48 hours. Researchers will compare a group whose dose is adjusted using the monitor to a …

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This international study is evaluating a minimally invasive procedure to close a type of heart defect called a perimembranous ventricular septal defect (PmVSD) — a hole between the heart's lower chambers. The procedure uses a small device inserted through a catheter to plug the h…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…

This study looks back at medical records of heart attack patients with a large clot in a coronary artery. It compares two ways to reopen the blocked artery during emergency angioplasty: a drug-coated balloon that delivers medication and is then removed, versus a drug-eluting sten…

This trial tests whether injecting nicorandil directly into the coronary artery before balloon angioplasty and stenting can prevent a drop in blood flow, a complication called no-reflow. The study enrolls adults with coronary artery disease who have a high lipid core burden index…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study enrolls 600 women with blocked heart arteries to compare two common procedures: bypass surgery (CABG) and stenting (PCI). The goal is to see which one leads to better survival and quality of life. Participants will be followed over time to measure outcomes.

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This early-stage study tests a new medicine called AZD4063 in 31 adults with a specific genetic form of dilated cardiomyopathy (PLN R14del). The main goal is to check the drug's safety and how the body processes it. Participants receive the drug as an injection under the skin and…

This study tests whether the Edwards EVOQUE system, a valve replacement delivered through a catheter, can safely and effectively treat tricuspid regurgitation, a condition where the tricuspid valve fails to close properly. Researchers will enroll 500 adults in Europe who are deem…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This trial tests whether traditional open-heart surgery to replace a narrowed aortic valve works as well as a less invasive catheter-based approach in patients with severe aortic stenosis who are otherwise at low surgical risk. Researchers will compare rates of death, stroke, and…

This study compares a newer pacing method (Left Bundle Branch Area Pacing) with the standard cardiac resynchronization therapy for people with heart failure. About 850 adults with moderate to severe heart failure will take part. The goal is to see if the newer method reduces deat…

This study tests whether a short course of amiodarone can reduce the return and burden of atrial fibrillation (AF) in 400 adults who develop new AF after heart surgery. Participants receive either standard care or amiodarone for 4 weeks. The goal is to see if this approach is pra…

This study tests a drug called depemokimab in adults with hypereosinophilic syndrome (HES), a rare condition where too many eosinophils (a type of white blood cell) cause organ damage. The trial includes 123 people whose HES is not well controlled despite standard therapy. Partic…

This study tests whether gonadal tissue removed from children with disorders of sex development (DSD) can be frozen and stored to preserve fertility. The tissue is already being removed for medical reasons, such as preventing cancer. Researchers will check the tissue for viable g…

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This study compares a new, tailored ablation approach to the standard treatment for people with paroxysmal atrial fibrillation (AFib), a common heart rhythm problem. About 556 adults with AFib will be randomly assigned to either standard pulmonary vein isolation or a procedure th…

This trial tests whether tailoring breathing support to each patient protects the lungs better than a standard fixed setting during heart bypass surgery. Researchers will compare two methods of setting positive end-expiratory pressure, or PEEP, in 86 adults having on-pump coronar…

This pilot study compares two ablation techniques for treating ventricular tachycardia, a fast and dangerous heart rhythm that can occur after a heart attack. Researchers will randomly assign 40 adults with ischemic heart disease and an implantable defibrillator to receive either…

This study is testing a new device called the Sphere-9 catheter, used with the Affera mapping system, to treat ventricular tachycardia (VT) — a fast, dangerous heart rhythm. The procedure uses heat to destroy small areas of scarred heart tissue that cause the abnormal rhythm. The…

This Phase 3 trial tests whether DYNE-101 can improve muscle function and daily life in 150 adults with myotonic dystrophy type 1 (DM1). Participants receive either the drug or a placebo by IV every few weeks for 48 weeks. The study measures how quickly people can stand from a ch…

This Phase 3 study tests whether adding vicadrostat to the standard drug empagliflozin helps adults with chronic heart failure and a weak heart pump (ejection fraction below 40%). About 4200 participants will take either vicadrostat or a placebo, plus empagliflozin, once daily fo…

This trial tests whether a 16-week supervised exercise program can reduce symptoms of postural orthostatic tachycardia syndrome (POTS), a condition that causes a sharp rise in heart rate and symptoms like dizziness and fatigue when standing. Researchers at Lund University will en…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study compares two ways to treat long, diffuse blockages in heart arteries. One method uses a temporary scaffold and drug-coated balloons that leave no permanent metal behind. The other uses standard metal stents. Researchers will check how well blood flow improves right aft…

This trial tests whether a wearable vest that measures lung fluid content can help doctors guide diuretic treatment in patients hospitalized with acute decompensated heart failure. The vest uses remote dielectric sensing to non-invasively estimate fluid levels in the lungs. Resea…

This study is checking how safe and well a device called TriClip works for people with a leaky heart valve (tricuspid regurgitation). The device is already approved for use, and this study will watch 1000 adults who get it to see how they do. The goal is to make sure the device w…

This trial tests whether finerenone, a drug that reduces inflammation and scarring, can lower the chance of atrial fibrillation returning after a catheter ablation. About 40 adults with atrial fibrillation will receive finerenone or usual care for 12 months after their first abla…

This early-stage trial tests a single IV dose of VERVE-102, a gene-editing drug designed to permanently lower LDL (bad) cholesterol by turning off a specific gene in the liver. It involves 85 adults with inherited high cholesterol or early heart disease who still need lower chole…

This study tests the long-term safety and effectiveness of an investigational drug called danicamtiv in adults with symptomatic genetic or familial dilated cardiomyopathy (DCM), a condition where the heart muscle weakens and enlarges. Participants who completed a prior 24-week st…

This pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…

This study tests whether metformin, a standard diabetes medicine, can improve heart function in people who have received a mechanical heart pump (LVAD) for severe heart failure. Researchers will give metformin or a placebo to 108 patients for 12 months and check heart function, b…

This study is tracking 1000 people with atrial fibrillation who receive the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to prevent blood clots from causing strokes. The goal is to see how safe and effective the device is in everyday medical practi…

This study tests a new device called SynFlow Duro, a temporary heart pump for people who go into severe shock after heart surgery. About 60 adults in China will receive the pump to see if it helps their heart recover or keeps them stable until a transplant or permanent device. Th…

This study tests whether taking a low dose of colchicine (a medicine used for gout) every day for a year can prevent the new blood vessels created during heart bypass surgery from failing. About 100 adults who recently had bypass surgery will take colchicine or no extra treatment…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

Some people are born with only one working lower heart chamber, a condition often managed with a Fontan operation. Over time, that single ventricle can weaken, leading to Fontan circulatory failure, where the heart struggles to pump enough oxygen-rich blood. This trial tests whet…

This study tests whether a structured cardiac rehabilitation program can improve outcomes for people who survived a cardiogenic shock, a life-threatening condition where the heart suddenly fails to pump enough blood. Researchers will enroll 2,000 patients across Italy and compare…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study looks at whether people with heart failure caused by a treatable problem, like a blocked artery or a faulty heart valve, can safely wait to start certain heart failure medications after the problem is fixed. About 80 adults whose heart function improved after surgery o…

This trial tests whether a clopidogrel-based antiplatelet regimen is as effective as aspirin plus low-dose rivaroxaban in preventing heart attacks, strokes, and other vascular events. Adults with a history of heart attack or peripheral artery disease will be randomly assigned to …

This trial tests a new device called the MRace implant, designed to reduce severe mitral regurgitation—a condition where the heart's mitral valve leaks blood backward. The implant is placed via a catheter through a vein in the leg, avoiding open-heart surgery. The study will enro…

This early study tests a device called the MRace implant to treat moderate-to-severe mitral regurgitation, a condition where the heart valve leaks. About 15 people will get the implant and be followed for up to 5 years to see if it safely reduces the leak and improves symptoms. T…

This study looks at whether low-dose beta-blockers can reduce dangerous heart rhythms in people who have survived a cardiac arrest with no clear cause. About 218 participants will receive one of several beta-blockers and be followed for up to 3 years. The goal is to see if this t…

This study looks at children aged 2 to 18 having minimally invasive heart surgery to fix simple defects. Researchers compare two approaches: giving sugammadex in doses adjusted to real-time nerve monitoring, versus letting muscle relaxation wear off naturally. The goal is to see …

This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goa…

This trial tests a new device called the MRace implant, which is placed in the mitral valve through a catheter inserted via a vein in the leg. The goal is to reduce severe mitral regurgitation, a condition where the valve leaks blood backward, to a milder level. The study enrolls…

This early-stage trial tests a single intravenous dose of AFTX-201, a gene therapy designed to deliver a working copy of the BAG3 gene to heart cells. It enrolls 22 adults aged 18–55 with dilated cardiomyopathy and a BAG3 mutation. The study primarily checks safety and tolerabili…

This phase 2 trial tests whether EDG-15400, an oral drug taken once daily, can safely improve symptoms and heart function in adults with heart failure with preserved ejection fraction (HFpEF). Participants receive either EDG-15400 or a placebo for a period of time, while research…

This study follows 30 people with Alagille syndrome who are taking odevixibat (Bylvay) in their daily lives. The goal is to see if the drug helps them avoid serious surgeries like liver transplant or bile duct repair over the long term. Researchers will also track weight, height,…

This study is checking the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants who have symptoms and haven't respon…

This study tests whether AI-generated messages can help doctors improve medication plans for adults with heart failure. About 500 patients will have their doctors receive brief suggestions before appointments. The goal is to see if more patients get the right medications within 3…

This study looks at whether drug-coated balloons, which deliver medication directly to the artery wall, work as well as drug-eluting stents in people with coronary artery disease. Researchers will track 1,000 patients who received either treatment to compare rates of artery re-bl…

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study will follow 30 people with Alagille syndrome who are taking odevixibat in their daily lives. The goal is to see how safe the drug is over the long term by tracking any side effects. It is not testing if the drug works, but rather monitoring its real-world safety.

This trial investigates whether a new dual energy catheter system can safely and effectively treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. The system uses both radiofrequency and pulsed field energy to ablate the heart tissue causing the probl…

This phase 2 trial tests budiodarone, an experimental drug, in about 100 people with non-permanent atrial fibrillation, especially the paroxysmal form. Researchers want to see if the drug can safely reduce or eliminate long episodes of irregular heartbeat that last five hours or …

This trial tests whether using a detailed CT scan of the heart's arteries before a procedure to open blockages (PCI) can make the procedure more efficient. About 200 adults with coronary artery disease will be randomly assigned to either have their procedure guided by a pre-plann…

This study tests whether dividing exercise intensity into three personalized zones, based on individual biological responses, improves aerobic fitness in people with coronary artery disease. Participants train on a cycle ergometer for three months in one of three intensity zones.…

This trial tests whether combining two advanced heart-mapping technologies can make ablation for ventricular tachycardia (VT) more accurate and effective. The approach merges a non-invasive 3D electrical map of the heart with detailed scar imaging from an MRI, aiming to better ta…

This trial tests whether vericiguat, a drug used for heart failure, can also help preserve brain health in people who have both chronic heart failure and mild-to-moderate cognitive impairment. Participants will receive either vericiguat or standard care for 26 weeks. The study us…

This trial is testing whether a higher dose of targeted radiation to the heart can reduce the return of ventricular tachycardia, a dangerous fast heart rhythm, in people with structural heart disease. The treatment, called stereotactic arrhythmia radioablation, aims to create sca…

This trial tests whether extending the compression pause from 3 to 5 seconds during mechanical CPR helps rescuers deliver two effective breaths more often. It includes adults who had a cardiac arrest outside the hospital and were treated with a LUCAS device. The study compares th…

This trial is investigating whether a combination of left bundle branch area pacing (a new way to pace the heart) and atrioventricular node ablation (a procedure to disrupt faulty electrical signals) can improve outcomes for people with symptomatic atrial fibrillation who haven't…

This trial compares two ways of guiding a heart procedure called pulsed field ablation, used to treat paroxysmal atrial fibrillation (an irregular heartbeat that comes and goes). About 292 people scheduled for this ablation will be randomly assigned to have the procedure guided b…

This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a c…

This trial tests whether planning coronary artery bypass grafting (CABG) using a non-invasive CT scan (CCTA) works as well as the standard invasive angiography (CAG). About 826 people with blocked heart arteries will be randomly assigned to have their surgery planned with one of …

This trial compares two ways to access the blood vessels during cardiac catheterization: through the wrist (radial access) versus through the groin using modern techniques (femoral access). The goal is to see which approach leads to fewer bleeding events and access-site complicat…

This trial tests whether a new transcatheter heart valve (Myval) works as safely and effectively as two existing valves (Sapien and Evolut) in people with severe aortic stenosis, a condition where the heart's main valve narrows. About 768 patients who are eligible for valve repla…

This trial investigates whether adding either metolazone or acetazolamide to standard loop diuretics helps adults hospitalized with acute heart failure and fluid overload. Participants are randomly assigned to one of three treatment arms, and the study tracks days alive and out o…

This trial investigates whether a five-week vegetarian diet can dampen the inflammatory response of the immune system in people who recently had a heart attack, as well as in healthy volunteers. Participants will follow a vegetarian diet for five weeks, then return to their usual…

This trial is testing whether a higher dose of adenosine, a drug used during cardiac MRI to stress the heart, improves blood flow imaging compared to the standard dose. The study includes 180 adults with suspected or known coronary artery disease or heart failure. By comparing th…

This trial tests whether a non-invasive mapping system called VIVO can help doctors locate the source of a dangerous heart rhythm called ventricular tachycardia (VT) before an invasive procedure. Patients with structural heart disease who need catheter ablation will be randomly a…

This trial asks whether clamping the umbilical cord at 120 seconds after birth is better than clamping at 30 seconds for babies born with congenital heart disease. About 500 infants with a prenatal heart defect diagnosis will be randomly assigned to one of the two timings. Resear…

This trial tests whether starting respiratory physiotherapy within one hour of breathing tube removal after elective coronary artery bypass surgery improves lung function and reduces complications compared to waiting until the next day. Forty adults undergoing planned heart surge…

This trial compares two blood thinners, edoxaban and apixaban, in people who have both atrial fibrillation (an irregular heartbeat) and coronary artery disease (narrowed heart arteries). Both drugs help prevent blood clots, but they are taken differently and may have different ri…

This trial tests whether a 3-month program of virtual visits and remote monitoring can improve recovery in adults recently hospitalized for heart failure. Participants receive either virtual heart failure care or routine care, and researchers track medication optimization, health…

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Particip…

This trial tests whether using a supraglottic airway (a mask-like device) instead of a breathing tube during heart surgery can reduce lung complications and speed recovery. Adults having elective heart valve surgery or bypass will be randomly assigned to either the nonintubated a…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This clinical trial is testing an experimental drug called CRD-4730 in people with heart failure with reduced ejection fraction (HFrEF), a condition where the heart's main pumping chamber is weak. The drug works by blocking a protein called CaMKII, which is thought to contribute …

This study tests whether giving thiamine (vitamin B1) during coronary artery bypass surgery can reduce the memory and thinking problems that sometimes follow the procedure. Older adults with coronary heart disease who are scheduled for bypass surgery and have low thiamine levels …

This trial is testing a new device called the AltaValve System, which is placed inside the heart to replace a leaky mitral valve. The study includes adults with moderate-to-severe mitral regurgitation who are not suitable for surgery or a less invasive repair procedure. The goal …

This trial asks whether people with permanent atrial fibrillation (AF) can continue drinking caffeinated coffee without worsening their heart rate control. Half of the participants will keep their usual coffee habit, while the other half will switch to decaf for a month, then swa…

This trial tests whether a smartphone app called HeartCheck can help people who have recently survived a heart attack better manage their blood pressure, cholesterol, blood sugar, and smoking habits. The app provides education, reminders, and easy-to-understand goals to support m…

This trial is testing whether sacubitril/valsartan, a newer heart failure medication, can improve heart function and reduce harmful heart remodeling better than the older drug ramipril. The study enrolls adults with ischemic heart failure (caused by reduced blood flow to the hear…

This registry tracks 5,000 people with coronary artery disease who receive one of three drug-eluting stents during angioplasty: Biolimus, Everolimus, or Zotarolimus. Researchers will compare rates of heart-related death, heart attack, and repeat procedures over two years. The goa…

This study tests the drug acoramidis in people with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart, weakening it. Over 36 months, researchers measure whether acoramidis improves heart function and structure using cardiac …

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This trial compares two single antiplatelet therapies—ticagrelor versus aspirin—in people who have just undergone transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. The goal is to see which drug better prevents serious complications like stroke, heart atta…

This trial compares two ways to guide ablation for ventricular tachycardia, a dangerous fast heart rhythm. One method uses standard voltage mapping to burn away all low-voltage scar tissue. The other uses a newer technique called ILAM that targets specific zones where the electri…

This trial investigates whether isolating the superior vena cava, in addition to the standard pulmonary vein isolation, improves success rates for treating atrial fibrillation. Using a newer, safer energy source called pulsed field ablation, the study compares the two procedures …

This trial investigates whether cardiac ablation — a procedure that destroys tiny areas of heart tissue causing irregular rhythms — can improve exercise capacity in endurance athletes with atrial fibrillation. One hundred athletes who train at least four hours per week will have …

This trial compares two catheter ablation strategies for people with persistent atrial fibrillation (AF). One group receives standard pulmonary vein isolation using pulsed-field ablation; the other receives radiofrequency ablation followed by additional map-guided targeting of ab…

This trial tests a new minimally invasive procedure called TRANSOM for people with a leaky mitral valve, a condition where the valve doesn't close properly. Instead of opening the chest, surgeons make a small incision between the ribs and insert a tube directly into the beating h…

This trial tests whether using two defibrillators in rapid succession, rather than one, can improve survival in people whose hearts stop outside a hospital. The procedure, called double sequential external defibrillation (DSED), is normally tried only after several failed attempt…

This trial tests whether ivabradine, a drug that lowers heart rate, can help people recover from cardiogenic shock—a life-threatening condition where the heart can't pump enough blood—after a heart attack. Participants receive either ivabradine or a placebo for three days, and do…

This study tests whether lumacaftor, a drug used for cystic fibrosis, can improve blood flow to the brain and thinking abilities in people with stable heart failure and reduced pumping function. About 60 participants will receive either lumacaftor or a placebo for one month. The …

This trial tests whether an experienced doctor's eye, guided by standard X-ray images, can place a heart stent as well as using a special ultrasound probe inside the artery. The study focuses on the left main coronary artery, a critical vessel. All patients receive the same type …

This trial tests whether the position of the electrodes on the chest — front-to-back versus front-to-side — and applying manual pressure to the electrodes improve the success of electrical cardioversion for atrial fibrillation. About 1750 adults scheduled for non-urgent cardiover…

This study tests whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard rate for patients with advanced kidney disease hospitalized due to severe fluid overload. Participants are randomly assigned to receive either a…

This study tests whether an electronic alert in a patient's medical record can prompt doctors to prescribe guideline-recommended heart failure medications that are not yet being used. The trial includes 5,000 adults with heart failure and a reduced ejection fraction (≤40%) seen a…

This trial tests a new device called the P3 Occluder System designed to close a patent foramen ovale (PFO) — a small opening between the upper chambers of the heart. The study includes adults aged 18 to 65 who have had a stroke possibly linked to a PFO. Participants receive the i…

This study tests two simple tools to improve medication use in people with heart failure with reduced ejection fraction (HFrEF). One tool is a short animated video and checklist sent to patients before a clinic visit to encourage them to discuss their medications. The other is an…

This study is testing the safety and performance of the Navitor TAVI system, a device used to replace a narrowed heart valve (aortic stenosis) without open-heart surgery. About 1,000 participants who are eligible for the procedure will receive the Navitor valve and be followed fo…

This phase 3 trial tests whether finerenone, a non-steroidal mineralocorticoid receptor antagonist, can reduce cardiovascular death and heart failure events in patients with heart failure and reduced ejection fraction who cannot tolerate or are not eligible for standard steroidal…

This study tests whether a chest-strap ECG wearable, the Frontier X Plus, can accurately detect heart rhythm problems compared to the standard MoMe ARC patch monitor. About 15 active adults who are already prescribed a heart monitor will wear both devices at the same time. Resear…

This study looks at whether a special 3D ultrasound technique called TrueVue can better find and measure calcium buildup on the mitral valve, a common heart problem. Researchers will compare the ultrasound images to CT scans in 100 adults who already need these tests. If successf…

Researchers are testing a noninvasive wearable sensor patch that uses near-infrared light to continuously measure tissue oxygen and blood flow in people hospitalized with cardiogenic shock after a heart attack or heart failure. Up to 20 adults in a cardiac intensive care unit wea…

Researchers are testing whether a newer type of CT scan, called photon-counting detector CT, can identify dangerous plaque in heart arteries and predict future heart attacks, chest pain hospitalizations, or heart-related death. The study enrolls 500 adults scheduled for a routine…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these scans are accurate at finding blocked arteries and predicting future heart problems like heart attacks. About 5,000 adults who need a he…

This study tests a special radioactive tracer called [68Ga]Ga-FAPI-46 for PET scans in 40 people with transthyretin cardiac amyloidosis (ATTR-CM), a condition where abnormal proteins build up in the heart. The goal is to see if this scan can measure scar-like activity in the hear…

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

This study is testing a new type of MRI, called hyperpolarized 13C MRI, to see if it can better identify which patients with heart disease will benefit from bypass surgery. The technique measures how the heart produces energy by tracking two simple molecules. Researchers will com…

This study will test new ultrasound techniques, combined with artificial intelligence, to more accurately measure heart filling pressure in patients who have both heart failure and atrial fibrillation. Current methods are unreliable for these patients, making diagnosis and treatm…

Paramedics and other prehospital providers often interpret ECGs under time pressure without expert backup. Missing a blocked coronary artery delays life-saving treatment, while false alarms send patients for unnecessary procedures. This trial randomizes 144 prehospital providers …

Researchers at Ohio State University are testing whether high-resolution contrast-enhanced MRI can show the scar tissue in the heart that matches the electrical rotors targeted during FIRM-guided ablation for atrial fibrillation. About 20 adults with symptomatic paroxysmal or per…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study is testing a new imaging agent called [18F]FT8 to see if it can help doctors better see and diagnose amyloidosis, a disease where abnormal proteins build up in organs like the heart. The study will involve 20 patients with amyloidosis and 5 healthy volunteers. Research…

This study will check how well a heart surgeon's visual estimate of the heart's pumping ability matches the more precise measurement from an ultrasound (TEE) during open-heart surgery. About 70 adults having planned heart surgery with a heart-lung machine will take part. The goal…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study looks at whether a simple blood test done in the ambulance can safely rule out a heart attack in people with chest pain. Many patients are taken to the hospital even though they are not having a heart attack. The test uses a portable device to measure a heart protein c…

This study tests whether a newer type of CT scan, called photon-counting CT, can accurately measure blood flow to the heart muscle and detect scarring or fibrosis. Researchers will compare the CT results with cardiac MRI and invasive coronary angiography in 100 patients with aort…

This study will enroll 1,000 adults aged 35-85 with chest pain or shortness of breath to see if a new, detailed MRI blood flow measurement can more accurately diagnose heart disease than standard MRI. Participants will receive a contrast agent called Gadavist during stress and re…

This study tests whether a cardiac imaging technique called a PYP scan can detect transthyretin amyloidosis in people aged 65 and older who have heart failure with preserved ejection fraction, also known as diastolic heart failure. The researchers will scan 515 participants to se…

This study tests whether a smartwatch can record a 9-lead ECG that is as accurate as the standard 12-lead ECG for diagnosing ST-elevation myocardial infarction (STEMI), a severe type of heart attack. Researchers will compare the diagnostic agreement between expert cardiologists r…

This study tests whether a new radioactive dye, 68Ga-FAPI, can spot active scarring in the heart muscle using PET-MR scans. Researchers will scan about 290 people with various heart muscle conditions, such as heart failure with preserved ejection fraction, hypertrophic cardiomyop…

This trial tests whether a smartphone app using the camera's light sensor can detect atrial fibrillation (AF), a common heart rhythm disorder that raises stroke risk. About 554 adults with heart conditions will have their heart rhythm measured simultaneously by a standard 12-lead…

This study is testing a new MRI technique called CATCH to improve how doctors evaluate coronary atherosclerosis—the buildup of plaque in heart arteries. The goal is to make the scan faster, simpler, and more reliable than current methods, especially for identifying 'hot spots'—pl…

This trial tests whether an artificial intelligence tool can help doctors detect undiagnosed atrial fibrillation and structural heart disease from routine electrocardiograms (ECGs). About 1,000 healthcare providers are randomly assigned to either receive AI-generated risk alerts …

This study tests whether a quantitative analysis of bone scintigraphy (SUVmax) can better track amyloid burden in the hearts of patients with transthyretin cardiac amyloidosis who are being treated with tafamidis. The current Perugini score is limited in assessing disease severit…

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This trial tests whether a machine-learning algorithm can detect atrial fibrillation (AF) early by analyzing pulse wave signals from a wearable sensor. The study involves 200 adults with heart failure, comparing the algorithm's readings against standard ECG results. If it works, …

This study investigates whether a portable, AI-assisted ultrasound device can accurately measure heart function in patients aged 75 and older hospitalized with heart failure. Geriatricians, after a one-day training, use the AI tool to assess the heart's pumping ability, and resul…

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This trial investigates whether adding a simple blood test (NT-proBNP) and a quick heart ultrasound (POCUS) to standard care helps doctors diagnose heart failure more accurately in people aged 50 and older. Participants are randomly assigned to receive standard care alone or with…

This trial investigates whether an ultrasound of the neck arteries can provide similar information to a CT scan of the heart for diagnosing blocked arteries in people with chest pain. Currently, CT scans are used but involve a small amount of radiation. The study will compare the…

This study investigates whether a blood test measuring clotting and clot-busting markers can predict complications in patients undergoing aortic valve replacement. Researchers will follow 750 adults with aortic stenosis who receive either surgical or catheter-based valve replacem…

Children who receive a heart transplant need powerful drugs to stop their immune system from attacking the new organ. Researchers are testing a different approach: they collect regulatory T cells, a type of immune cell that dampens rejection, from thymus tissue that is normally d…

Researchers are testing a device called the Append System to close off the left atrial appendage, a small pouch in the heart, in people with non-valvular atrial fibrillation. The procedure uses a catheter to fold and tie off the pouch, with the goal of reducing the risk of blood …

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

After a cardiac arrest, many survivors develop seizures that can worsen brain injury. This trial tests whether giving the drug perampanel soon after resuscitation can prevent those seizures. About 52 adults who are comatose after a cardiac arrest will receive either perampanel or…

Heart failure often goes undiagnosed because its early symptoms—like fatigue and shortness of breath—are mistaken for normal aging. This study tests whether a three-part strategy can change that: raising awareness among patients and doctors, using a blood test (NT-proBNP) to spot…

This trial investigates whether a short course of atorvastatin, a widely used statin, can prevent atrial fibrillation—a rapid, irregular heartbeat—in adults aged 60 and older undergoing lung surgery. Participants are randomly assigned to receive either atorvastatin or a placebo f…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This trial tests whether making a small opening in the sac around the heart (posterior pericardiotomy) during heart surgery can prevent a common complication called atrial fibrillation. About 650 adults in China having surgery on the heart's valves, coronary arteries, or aorta wi…

Researchers are testing whether MLC901 (NeuroAiD II), a natural capsule, helps people recover after a mild to moderate ischemic stroke. The trial enrolls 80 adults aged 18 to 80 who are within 2 to 10 days of their stroke. Participants receive either MLC901 plus standard stroke c…

Acute coronary syndrome, which includes heart attacks, often triggers intense anxiety during the rush to hospital. Researchers are testing whether playing music for 20 minutes in the ambulance, on top of usual care, lowers anxiety and pain more than usual care alone. The trial en…

Tricuspid regurgitation happens when the heart's tricuspid valve leaks, letting blood flow backward. Open heart surgery to fix it carries high risks, and some people are not eligible for other catheter-based repairs. This study tests the Lux-Valve Plus, a replacement valve delive…

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

Researchers are testing a new balloon device called SmartWave that uses shock waves to break up calcium in severely narrowed mitral valves. The study enrolls 10 adults with symptomatic mitral stenosis caused by mitral annular calcification or severely calcified rheumatic heart di…

This study tests an injectable drug called HRS-9057 in 153 adults hospitalized with heart failure who have fluid retention. The main goal is to see if the drug reduces weight (a sign of fluid loss) by day 8 compared to a placebo. Researchers will also check safety and whether pat…

Researchers are testing whether warming the wrist with a forced-air warmer helps doctors place arterial catheters on the first try in babies and toddlers having heart surgery. The trial includes 126 children aged 2 years or younger. Half receive local warming before the procedure…

This study tests a flexible palliative care program for people with advanced heart failure or certain cancers. The program adds more team members—like a social worker or nurse—as symptoms get worse. The goal is to improve quality of life and match care to each person's changing n…

Researchers are testing whether a yoga-based cardiac rehabilitation programme works as well as a health education programme for people recovering from heart failure. The trial enrolls adults with heart failure and reduced ejection fraction who are well enough to attend hospital-b…

Researchers are testing whether a pacing technique called left bundle branch area pacing, guided by detailed imaging and electrical data, can improve outcomes for people with heart failure and left bundle branch block. The trial enrolls 100 adults with non-ischemic cardiomyopathy…

This study tests an 8-week mindfulness program designed to reduce anxiety and improve quality of life in women with coronary artery disease. Researchers will enroll 70 women who have had CAD for at least a month and have elevated anxiety. The program includes meditation, breathin…

This study looks at whether doing simple breathing exercises every day before a heart transplant can help patients breathe, cough, and swallow better after surgery. About 90 adults waiting for a heart transplant will take part. They will do daily breathing exercises and have thei…

Researchers are tracking 500 people with heart failure and reduced ejection fraction who received the Barostim Neo device, which stimulates nerves near the carotid artery to calm the body's stress response. The registry follows participants for six months to see whether the devic…

This study tests a virtual psychological support program called HeartGPS for mothers whose babies are diagnosed with congenital heart disease before birth. About 210 mothers and their infants will take part, with some receiving the program plus usual care and others only usual ca…

Researchers are testing a targeted ablation method for people with structural heart disease who have ventricular tachycardia, a dangerous fast heart rhythm. The procedure maps conducting channels inside heart scar tissue by pacing many sites, then uses radiofrequency energy to bl…

Children having corrective heart surgery through a chest incision often need strong pain medicine. This trial compares two ultrasound-guided nerve blocks, a parasternal intercostal plane block and an erector spinae plane block, both using a mix of bupivacaine and lidocaine. All c…

This study tests an experimental medicine called BAY 3670549 in 360 adults with atrial fibrillation (an irregular heartbeat). Participants receive a single IV dose of the drug or a placebo to see if it can restore normal heart rhythm without needing an electrical shock procedure.…

This study tests an investigational nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. About 750 adults will be randomly assigned to use either the real spray or a placebo at home when symptoms start. Th…

Researchers are testing a device called the Pedal Pump, which pumps both feet for 10 minutes to mobilize the body and improve lymphatic flow. The trial enrolls 30 hospitalized patients with lower extremity edema caused by heart failure, chronic venous insufficiency, kidney diseas…

This study tests whether playing soft music or using a musical mobile can reduce pain and stress in infants when chest tubes are removed after heart surgery. Fifty-four babies aged 2 to 12 months will be randomly assigned to hear music, see a musical mobile, or receive standard c…

This study tests if using a camera inside the heart (intracardiac echocardiography) is as safe and effective as the standard throat camera (transesophageal echocardiography) for guiding a procedure to close a heart pouch. The goal is to prevent strokes in people with an irregular…

This study tests a drug called DT402 (a form of MDMA) in 20 adults with autism spectrum disorder. The goal is to see if it can reduce the severity of social and communication problems. Participants will take the drug and report their experiences using simple rating scales. It is …

This study looks at whether giving a carbohydrate drink before coronary artery bypass surgery can improve insulin sensitivity and recovery in people with type 2 diabetes. About 50 participants will be enrolled. The goal is to see if this simple step can reduce complications and s…

This early-stage trial is testing a new drug called NNC0537-1482 in 36 adults with heart failure. The main goal is to check if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo by injection, and neither they nor the doctors will …

This study tests whether adding lidocaine to the Custodiol solution used during heart bypass surgery can reduce dangerous heart rhythms that often occur after the heart is restarted. About 70 adults having planned coronary bypass surgery will be randomly assigned to receive eithe…

This trial tests whether combining several regional nerve blocks can improve pain control and recovery in people undergoing off-pump coronary artery bypass surgery. Participants receive either a combination of local anesthetic injections or a placebo, and researchers measure how …

This trial tests whether a 24-week personalized program called MICROFIT—combining high-intensity interval training with a personal trainer and Mediterranean-style dietary advice—is feasible for people with microvascular coronary dysfunction, a condition where small heart blood ve…

This trial is testing whether a mild sedation combination of remimazolam and fentanyl can be used instead of general anesthesia during a pulsed-field ablation procedure for atrial fibrillation. The study will enroll 20 adults with paroxysmal or persistent AF and monitor how well …

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This study tests whether a supervised cardiac rehabilitation program is feasible and beneficial for people with cardiac amyloidosis, a condition where abnormal protein builds up in the heart. Participants attend three one-hour exercise sessions per week for 12 weeks. The study me…

This pilot study tests a program called Heartsight, which provides educational modules to caregivers of children who have had a cardiac arrest. The goal is to see if the program is feasible and acceptable, and whether it can reduce caregivers' uncertainty, anxiety, depression, an…

This study tests a new care model called TIER-HF-PC, which matches heart failure patients to one of three levels of palliative support based on their needs. Researchers want to see if this approach improves quality of life for both patients and their caregivers compared to usual …

After a cardiac arrest, the brain can suffer from dangerous pressure changes. This pilot study at National Taiwan University Hospital is testing a method to directly monitor brain pressure and blood flow in 50 patients who remain in a coma after their heart is restarted. Research…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study tracks over 16,000 teens and adults with severe asthma to see if the drug tezepelumab raises the risk of serious heart problems like heart attack, stroke, or heart-related death. Researchers will compare those taking tezepelumab to those on standard asthma treatments. …

This study will collect information from 15 patients in Asia-Pacific who have had or will have a less invasive procedure to fix a failed mitral or tricuspid heart valve. The goal is to learn how well these procedures work in this population, since most existing data comes from We…

This study aims to better understand takotsubo cardiomyopathy, also known as broken heart syndrome, by using manganese-enhanced MRI scans. Researchers will test how different heart medications affect manganese uptake in the heart muscle. The study involves 100 adults who have had…

This study follows 100 people who had heart bypass surgery guided by a special CT scan, to see if imaging details and a blood fat called Lp(a) can predict how well they do afterward. Researchers will track symptoms, quality of life, and major heart events like heart attacks or st…

People admitted for acute coronary syndrome, which includes heart attacks and unstable angina, face a higher risk of dangerous heart rhythms such as sustained ventricular tachycardia and ventricular fibrillation. Hospitals monitor these patients, but the exact rate of these rhyth…

This study is testing a new way to measure liver function in adults who have had the Fontan procedure, a surgery for certain heart defects. Researchers will use a dual cholate clearance test (a special blood test) and a heart MRI to see how well the liver is working. They will co…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

Researchers at Sahlgrenska University Hospital in Sweden are observing 200 adults hospitalized for a severe COPD flare-up to see how often the condition triggers a temporary heart muscle weakness called Takotsubo stunning. They will use echocardiograms to check heart function at …

Researchers at Al-Kadhimiya Teaching Hospital in Baghdad are studying how delays before and during hospital care affect outcomes for people who have a heart attack. The study follows 200 patients who receive reperfusion therapy, such as clot-busting drugs or angioplasty, within 1…

Researchers compare two hand positions for chest compressions: the standard interlocked-finger technique and an overlapped-hands technique. Adults with and without medical training perform two minutes of compressions on a manikin. The study measures compression depth, rate, and r…

Researchers are building a global registry to collect patient-reported surveys, genetic test results, and medical records from people with Charcot-Marie-Tooth disease and related inherited neuropathies. The study is open to children and adults with a confirmed or suspected diagno…

This study looks at 50 adults with AL amyloidosis who achieved complete remission after initial chemotherapy. It checks if tiny amounts of remaining disease (called minimal residual disease, or MRD) affect organ recovery and survival. Researchers also test whether a stem cell tra…

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study follows about 50 members of a family with a rare inherited condition called familial hypereosinophilia, where high levels of a type of white blood cell can damage the heart and nerves. Researchers will track participants over many years with yearly checkups, blood test…

Researchers are studying how non-invasive tools can characterize tricuspid regurgitation, a heart valve condition linked to heart failure and liver problems. The trial enrolls 450 adults with moderate or worse tricuspid regurgitation and uses a lung fluid sensor and a liver stiff…

Researchers are tracking outcomes for 30 people with severe pure aortic regurgitation who receive a transcatheter aortic valve implantation using the JenaValve or J-Valve system. All participants are considered high-risk for open heart surgery. The study uses CT scans at 6 months…

This study follows people with Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) over time to learn how the condition progresses and affects daily life. Researchers will collect health data and patient feedback to identify patterns and potential markers of the disease. The goal i…

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two valve replacement options: TAVR (less invasive) and SAVR (surgery). 140 patients aged 70+ will be randomly assigned to either the structured approach…

Researchers are comparing two ways of running the heart-lung machine during coronary artery bypass surgery to see which triggers less body-wide inflammation. The study follows 80 adults having planned bypass surgery, split by the circulation technique their surgical team uses. In…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study follows 10 Chinese adults who have a specific gene mutation (BAG3) linked to dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Researchers will track changes in heart function, symptoms, and biomarkers over time to better understand how the…

People born with single-ventricle heart disease often have the Fontan operation, which reroutes blood flow but leaves them with reduced exercise capacity. Researchers at Hacettepe University are measuring lung function and breathing muscle strength alongside treadmill exercise te…

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

Researchers are following 3,000 Chinese adults with hypertrophic cardiomyopathy, a condition that thickens the heart muscle and can disrupt blood flow. The study records how patients are treated in everyday hospitals and tracks health events such as stroke, heart failure hospital…

Researchers are studying people with arrhythmia-induced cardiomyopathy, a condition where a fast or irregular heartbeat weakens the heart muscle. The study checks whether these patients carry more harmful gene variants than people with other types of cardiomyopathy or the general…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

Researchers are observing adults undergoing coronary artery bypass grafting to see how often cardiac output falls below a set threshold in the 30 minutes after general anesthesia begins. The study uses continuous arterial waveform monitoring to record cardiac index, blood pressur…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

Some cancer drugs cause rare but serious heart and metabolic problems. This study follows 5,000 cancer patients across several French hospitals who receive a dedicated heart checkup and ongoing follow-up through cardio-oncology programs. Researchers track how many patients benefi…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study follows 200 people having beating heart bypass surgery to see how well Getinge's devices perform and if they cause any problems. The devices help stabilize the heart and improve visibility during surgery. No extra tests or visits are needed—just information from the ho…

This study is observing 4,500 people who need pacemakers or similar heart devices. The goal is to create a tool that predicts who is at risk of developing a weakened heart from the device itself. By identifying high-risk patients early, doctors can choose better pacing methods to…

Immune checkpoint inhibitors help the body's immune system fight cancer, but in some patients they trigger dangerous heart inflammation and other cardiovascular problems. Researchers are combing through the World Health Organization's global drug safety database, two French natio…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

Researchers at University Hospital Basel are collecting information from routine care to compare treatments for coronary artery disease. The registry follows people who receive a percutaneous coronary intervention, including complex procedures, and who are treated with drug-eluti…

This study is a registry that will follow about 320 heart failure patients who receive the WiSE System, a device that helps the heart pump better. Researchers will watch for serious side effects within 30 days and check how well the device improves heart function and symptoms ove…

This study tests a special breastfeeding guideline for infants born with congenital heart disease (CHD). Researchers want to see if the guideline helps more mothers breastfeed directly and reduces stress. About 266 mother-infant pairs will take part across multiple hospitals, wit…

This study is a registry that collects information from 1,000 people with symptomatic mitral valve disease, including mitral regurgitation and stenosis. The goal is to better understand how correcting these heart valve problems with a less invasive procedure called transcatheter …

This trial tests whether using a risk score and a rapid blood test in the ambulance can help decide where to take patients with chest pain. About 1,048 adults at intermediate or high risk for a heart attack will be randomly assigned to either this new triage method or usual care.…

Takotsubo cardiomyopathy, often called broken heart syndrome, mimics a heart attack and is triggered by intense emotional or physical stress. Researchers at the University of Aberdeen are identifying every diagnosed case in Scotland since 2010 to measure death rates and hospitali…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study will observe how the Impella 5.5 heart pump changes the way the heart squeezes and works in adults with end-stage heart failure. Researchers will use ultrasound (echocardiography) to measure heart function before, right after, and 7-14 days after the pump is placed. Th…

Researchers at Wroclaw Medical University are studying what factors are linked to slow heartbeats, called bradycardia, in patients recovering from pulsed field ablation for atrial fibrillation. The study enrolls about 100 people who have this procedure, which uses pulsed energy t…

This study will follow about 2000 adults with a heart condition called ATTR-CM, where abnormal proteins build up and weaken the heart. Researchers want to see how patients do on a drug called vutrisiran in everyday medical care, not just in a controlled trial. They will measure s…

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

Researchers at the Heart Center Bad Berka run a registry that collects data on adults treated for heart rhythm problems. The registry follows people who receive medication, procedures such as ablation, or implanted cardiac devices. It tracks how safe and effective these treatment…

This observational study will analyze medical records from over 52,000 people with ATTR amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers want to learn about patients' symptoms, treatments, and outcomes in everyday medical practice. No new treatm…

This study looks at whether certain carbon dioxide (CO2) measurements in the blood can help predict a serious complication called low cardiac output syndrome (LCOS) in children after heart surgery. LCOS happens when the heart doesn't pump enough blood, which can lead to longer ho…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…

This study is collecting information from 280 people who need a heart rhythm procedure using BIOTRONIK catheters, external devices, or sheaths. The goal is to track how well the devices work and any problems that may happen during or shortly after the procedure. It is a routine s…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study tests whether the Apple Watch's AFib History feature can accurately measure the amount of time spent in atrial fibrillation after a type of heart surgery called the Cox-Maze IV procedure. Researchers will compare the watch's readings to those from a standard medical de…

This study looks at why some people with heart failure don't get rid of excess fluid with standard water pills (diuretics). Researchers will test adding two other types of diuretics—bendroflumethiazide and amiloride—to see if they improve the body's response. Fifty adults with he…

This observational study will follow 200 adults with Brugada Syndrome who need anesthesia for surgery or other procedures. Researchers want to see how often dangerous heart rhythms occur during and up to 30 days after anesthesia. They will also check if certain anesthetic drugs o…

Researchers at the Cleveland Clinic are testing a prototype 4D intracardiac echocardiography (ICE) catheter that provides real-time ultrasound images from inside the heart. The study involves 20 adults scheduled for a left atrial appendage closure procedure, a common treatment fo…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …

This study tests a new paired-ring sizing tool used during mitral valve repair surgery. The tool measures the length of leaflet coaptation, which is how well the valve leaflets seal. Researchers want to see if this method gives accurate measurements compared to standard echocardi…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the link betwee…

This study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic fields to detect blocked arteries (ischemia). Researchers will enroll 150 adults scheduled for heart catheterization to see if the device can accurately predict heart attack status. T…

This study follows 1,000 adults with myotonic dystrophy type 1 (DM1) over time to measure how the disease progresses. Researchers will track walking speed, hand muscle relaxation, grip strength, heart and lung function, and daily activity. The goal is to establish reliable biomar…

This study tests whether showing real-time visual feedback to EMS responders helps them deliver the right amount of air during simulated CPR. 80 rescuers will give breaths to a mannequin with and without feedback, using two different CPR strategies. The goal is to see if feedback…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This trial is testing a medical device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety in people. Participants will be monitored closely, but the device is not yet proven to treat or cure any condition.

This study looks at why some adults who had the Fontan procedure as children develop serious liver scarring. Researchers will use blood tests, imaging, and liver biopsies to track changes and find early markers of disease. The goal is to better understand the process and pave the…

This study follows about 1,400 people with coronary heart disease who undergo a stent procedure, called PCI, to open blocked arteries. Even with standard treatment, these patients still face a risk of major heart events. Researchers will measure levels of a protein called hsCRP, …

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study is looking at whether a simple exercise test and other health factors can predict how well people recover after a procedure called TAVI, which replaces a narrowed heart valve. Researchers will follow 161 patients with severe aortic stenosis to see which factors before …

This study follows 65 people with Friedreich ataxia who also have a thickened heart muscle (cardiomyopathy). Researchers will measure changes in heart structure over time using imaging. The goal is to better understand how heart disease progresses in this condition, which could h…

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This study aims to find out how often exocrine pancreatic insufficiency (EPI) occurs in people with Alagille syndrome who have had a liver transplant. About 30 participants aged 7 to 50 will eat a high-fat diet and collect stool samples for lab testing. The results will help doct…

This registry will follow 2,500 people who receive Abbott heart devices, such as implants for holes in the heart or replacement heart valves. The goal is to check how safe and effective these devices are when used in everyday hospital practice. Data will be collected from standar…

This study looks at whether a person's genetic makeup can predict how well they respond to the heart failure drug metoprolol. Researchers will give the drug to 100 people with heart failure and track their heart function and drug levels. The goal is to see if a genetic score can …

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study is looking for early signs of heart amyloidosis in Black adults who carry a specific gene change (V122I TTR) that raises their risk. Researchers will use heart MRI scans and blood tests to detect protein buildup before symptoms appear. The goal is to find ways to diagn…

This study aims to develop and fine-tune a medical artificial intelligence (AI) model to assist with diagnosing and managing gastric, cardiovascular, and cerebrovascular diseases. Researchers will use a large dataset of patient records, medical images, and doctor-patient dialogue…

This observational study follows 1000 adults with cardiac implantable electronic devices, such as pacemakers and defibrillators, to see how these devices affect tricuspid regurgitation, a condition where the heart's tricuspid valve leaks. Researchers will use 3D echocardiography …

This study looks at people with severe aortic stenosis, a narrowing of the heart's main valve, who are scheduled for a procedure called TAVI to replace that valve. Researchers want to see if improving blood flow through the valve also reduces fluid buildup in the lungs, a sign of…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study is observing 3000 adults with various types of heart failure to learn how the disease develops and progresses. Researchers will collect medical records, blood samples, and imaging data to identify distinct patient groups. The goal is to match the right treatments to th…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study tests whether artificial intelligence can use continuous ECG data to predict and detect life-threatening heart arrhythmias in patients admitted with acute cardiac illness. Researchers will analyze stored ECG data from 3000 adult patients to see if AI models can forecas…

This trial tests whether drinking 400 mL of red grape juice daily for three weeks alters the blood metabolome—the collection of small molecules in blood—in people with chronic coronary artery disease. Participants alternate between a grape juice period and a period without polyph…

This study aims to create a network of biobanks across Italy that collect and store biological samples and health data from people with rare diseases and their families. The goal is to standardize how samples are collected and shared, so researchers can access high-quality materi…

This trial tests whether an augmented reality (AR) system can help healthcare providers deliver high-quality chest compressions during a simulated pediatric cardiac arrest. Participants, who are nurses or technicians with pediatric life support certification, will perform CPR for…

This observational study aims to uncover clinical and genetic risk factors for sudden cardiac arrest and death in patients with coronary artery disease (CAD). Researchers will follow about 4,000 participants who have been diagnosed with CAD, collecting data from surveys, ECG reco…

This study is a national registry in France that will follow young people aged 12 to 35 who experience sudden cardiac arrest or death during sports. Researchers will perform thorough medical investigations, including autopsies and whole exome genetic testing, to try to find the u…

This study aims to understand why fatty plaques in heart arteries suddenly rupture, causing heart attacks, and why some people experience more heart muscle damage than others. Researchers will use advanced imaging, blood tests, and genetic analysis in about 2,000 patients undergo…

This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and c…

This observational study tests a new spectroscopic device designed to measure oxygen levels in the heart muscle during open-heart surgery. The goal is to see if the device can safely record this data and how it relates to surgical events and patient parameters. Participants are a…

This pilot study investigates whether empagliflozin, a diabetes drug, can improve microcirculation—the function of tiny blood vessels—in patients with cardiogenic shock, a condition where the heart fails to pump enough blood. Researchers will use a video microscope to measure mic…

This study follows 400 adults who recently had a stent placed for coronary artery disease to see if long-term exposure to cold regions affects heart recovery. Participants' cold exposure is measured by where they lived and worked in the three years before the procedure. The study…

This study compares two ultrasound techniques—2D and 3D speckle-tracking echocardiography—to see which measures heart muscle contraction more accurately in people with heart failure and reduced pumping function. Researchers will enroll 419 patients from seven cardiac rehabilitati…

This study gathers information from many hospitals on procedures used to open completely blocked coronary arteries—a condition called chronic total occlusion—in people with advanced heart disease. Researchers will track which techniques are used and how well they work, both right…

This study looks at how the depth of anesthesia during cardiac surgery might influence heart function. Adults having elective on-pump heart surgery are randomly assigned to either standard or deeper anesthesia, guided by a brain monitor. Doctors measure heart performance using ul…

This study investigates whether the types and behavior of certain immune cells (neutrophils and monocytes) in the blood are linked to how the heart repairs itself after a heart attack. Researchers will follow 50 adults who have had a severe type of heart attack and are scheduled …

This study looks at whether liver function and blood clotting tests can help doctors better understand and monitor cardiac transthyretin amyloidosis (ATTR-CA), a condition where abnormal protein builds up in the heart. Researchers will compare these tests in people with ATTR-CA a…

This study looks at whether certain fat molecules in the blood, called lipids and ceramides, are linked to atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from people with atrial fibrillation to those with other heart conditions but no a…

This study observes how core body temperature changes in adults who experience cardiac arrest outside the hospital. Researchers will measure temperature using a probe inserted into the esophagus during resuscitation and transport to the hospital. They will also track environmenta…

This study aims to understand why some people with heart failure respond well to standard guideline-directed medical therapy while others do not. By analyzing genetic data and biomarkers from a large biobank of 5,000 patients, researchers hope to identify predictors of treatment …

This study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This pilot study tests whether a special MRI technique can measure wall shear stress—the force of blood against vein walls—in the pulmonary veins of infants. These veins carry blood from the lungs to the heart, and narrowing them (pulmonary vein stenosis) is a life-threatening co…

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study tests whether a machine learning model can predict the outcome of a common heart procedure — placing a stent to open a hardened, calcified artery. Researchers will measure blood flow and pressure before and after the procedure in 100 adults with coronary artery disease…

This study screens children and adolescents aged 5 to 18 who have chronic conditions like congenital heart disease, inflammatory bowel disease, celiac disease, or rheumatic diseases for lipid metabolism disorders. Participants provide a blood sample and complete a questionnaire a…

This study aims to create a better way to predict stroke risk in people with atrial fibrillation (an irregular heartbeat) who are already taking direct oral anticoagulants (DOACs), a type of blood thinner. Even with these medications, some patients still have strokes. Researchers…

This observational study investigates whether blood clotting markers and heart ultrasound measurements can help assess stroke risk in people with device-detected atrial fibrillation—a brief, symptomless irregular heart rhythm picked up by pacemakers or similar implants. Researche…

This study follows 400 people in Norway with multiple myeloma, plasma cell leukemia, or AL amyloidosis who are receiving newer immunotherapies like teclistamab, elranatamab, or CAR-T cell therapy outside of clinical trials. Researchers will track how well these treatments control…

This study is a large registry that collects data from thousands of patients across Asia who have undergone transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. Researchers will analyze medical records to see how well the valves perform over time and what fac…

This study looks at why some people with severe heart failure (called HFrEF) see their heart function improve after standard medical therapy, while others do not. Researchers will collect blood samples and imaging data from 1,740 patients in China and follow them for 12 months. T…

This study investigates whether clonal hematopoiesis of indeterminate potential (CHIP)—a condition where blood cells carry certain mutations—plays a role in heart failure. Researchers will examine 300 adults with acute or chronic heart failure to see how common CHIP is and how it…