Could a tailored palliative care approach improve life for heart failure patients?
NCT ID NCT06244953
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This study tests a new care model called TIER-HF-PC, which matches heart failure patients to one of three levels of palliative support based on their needs. Researchers want to see if this approach improves quality of life for both patients and their caregivers compared to usual care. The trial involves 240 participants with advanced heart failure and follows them for up to 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a tiered palliative care model (TIER-HF-PC) that assigns patients to different levels of care based on their needs
- What this could lead to
- If successful, this could provide a practical, scalable way to integrate palliative care into heart failure management, improving quality of life for patients and easing the burden on caregivers.
- What could go wrong
- This is a relatively small study testing a complex care model, so results may not apply broadly. The intervention involves multiple components, making it hard to pinpoint which part works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2024
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 99 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients: 1. 21 years or older and 2. able to communicate in English/Chinese/Malay and 3. be of stage C or D heart failure, as defined by American College of Cardiology/American Heart Association (ACC/AHA) classification system and 4. have functional limitation of New York Heart Association (NYHA) functional status of at least 2 or more and 5. be deemed by their cardiologist's clinical judgement to have an expected prognosis of at least 6 months survival, and 6. have had a heart failure related hospitalization event (e.g. symptomatic decompensated heart failure) within 6 months prior to recruitment and 7. have a phone that allows telecommunication. * Caregivers must meet all the following inclusion criteria to be eligible for the study : * direct, unpaid, family caregiver of the patient; * self-reported by the patient to be the main person to be either: * responsible for up to 4 hours a day of caregiving tasks * and/or decision maker/spokesperson with the medical team * Caregiver may or may not live in the same residence as the patient. * Caregivers must be 21 years and above. * Able to communicate in English/Chinese/Malay. Exclusion Criteria: * Patients: 1. have cognitive impairment (e.g., dementia) 2. have severe, untreated, active mental illness (e.g., major depressive disorder) 3. have ventricular assist device implant. 4. have non-reversible hearing or visual loss or 5. are active drug abuser or 6. already known to a palliative care service. * Caregivers who meet any of the exclusion criteria at baseline will be ineligible for the study: * have cognitive impairment (e.g., dementia) or * have severe, untreated, active mental illness (e.g., major depressive disorder) * have non-reversible hearing or visual loss. * are active drug abuser or * are a domestic helper for the patient
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Khoo Teck Puat Hospital
RECRUITINGSingapore, 768828, Singapore
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National Cancer Centre, Singapore
RECRUITINGSingapore, Singapore
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National Heart Centre Singapore
RECRUITINGSingapore, 169609, Singapore
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Sengkang General Hospital
RECRUITINGSingapore, 544886, Singapore
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Other studies related to the condition(s) this trial covers.
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