HEART FAILURE

This study tests whether an AI-powered health coach can help 300 adults with heart disease, diabetes, or kidney disease better manage their conditions. Participants use a smartphone app and monitoring devices to track health markers and get personalized guidance. The goal is to r…

This study tests if injecting lab-grown heart muscle cells into the heart can help people with advanced heart failure. About 80 adults with severe symptoms will receive the cells or a placebo during bypass surgery. The main goal is to see if they can walk farther in 6 minutes and…

This study looks at whether using smartphone apps and sensor devices, along with personalized text messages, can help people with chronic heart failure stick to their self-care routines and reduce time spent in the hospital or risk of death. About 360 adults with Stage C heart fa…

This study tests whether a new drug, vicadrostat, works differently than the older drug spironolactone when both are taken with empagliflozin. About 100 adults with chronic kidney disease and heart disease or heart failure will take one of the two combinations for 26 weeks. Resea…

This study looks at whether cancer survivors who had temporary heart damage from chemotherapy can safely stop taking heart failure medications once their heart function has recovered. About 335 adults who finished cancer treatment at least 6 months ago and are currently on heart …

This study tests whether a one-year program led by heart failure nurses, using online training and a mobile app, can reduce hospital readmissions and improve quality of life for people hospitalized with heart failure. About 200 patients will either receive the program or standard…

This study tests whether a drug called sodium zirconium cyclosilicate (SZC) can safely lower potassium levels in elderly patients with heart failure and chronic kidney disease. By controlling potassium, doctors hope to give these patients higher, more effective doses of heart-pro…

This study compares a new pacing method called LOT-CRT to standard biventricular pacing in 86 heart failure patients with a specific type of heart block (NICD). The goal is to see if LOT-CRT better preserves or improves the heart's pumping ability. Participants will be followed f…

This study tests whether simple digital checklists and reminders can help doctors prescribe the best combination of heart failure medications to more patients. Researchers will enroll 4,000 adults with heart failure and a weak heart pump. The goal is to see if these tools increas…

This study is testing a new device called the Supira System in 45 people with heart failure and severe coronary artery disease who need a high-risk heart procedure. The device helps pump blood during and after the procedure, potentially reducing complications. The goal is to see …

This study tests whether the drug finerenone can reduce heart failure events and deaths in people hospitalized with acute heart failure who have a mildly reduced or preserved pumping ability. About 5,200 participants will receive either finerenone or a placebo. The goal is to see…

This study tests an investigational drug called omecamtiv mecarbil in 1800 adults with severe heart failure and a very weak heart pump. The goal is to see if the drug can lower the chance of heart failure worsening, needing a heart pump or transplant, or dying. Participants will …

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue with standard med…

This study tests an experimental pill (PF-07328948) for adults with heart failure. About 620 participants will receive either the drug or a placebo to see if it improves walking distance, symptoms, and reduces heart-related events. The goal is to better control the disease and im…

This study tests whether social prescribing—connecting patients with community resources for issues like housing, transportation, or loneliness—can help women with heart failure stick to their medications and improve their quality of life. About 200 women at high social risk will…

This study is testing whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care can improve outcomes for patients with heart failure and sudden kidney injury. Researchers will compare recovery, need for dialysis, and symptom relief between those wh…

This study tests a medicine called vericiguat in children with heart failure caused by a weak left heart pump. About 342 kids from 1 month to 18 years old will take either vericiguat or a placebo for 16 weeks. The goal is to see if the medicine lowers a heart stress marker (NT-pr…

This study tests a new machine that keeps donor hearts healthy outside the body before transplant. It focuses on hearts from donors who may not usually qualify, aiming to safely increase the number of available hearts. About 60 adults waiting for a heart transplant will take part…

This study tracks 5,500 people with heart failure who get a CCM device to see if it reduces hospital visits and stays over time. Researchers will also check for device-related problems. The goal is to learn how well this therapy works outside of controlled trials.

This study tests a special pacing method called high intensity his bundle pacing in 34 heart failure patients with narrow QRS (a heart rhythm pattern). The goal is to see if this pacing can improve the heart's pumping ability and quality of life. Participants already have an impl…

This study tests whether a preventive heart ablation procedure, done soon after implanting a defibrillator (ICD), can reduce dangerous heart rhythms in people with heart failure and high risk. About 62 participants with weak hearts and prior heart damage will be randomly assigned…

This study looks at people whose heart failure has improved so much that their heart function seems normal again. Currently, guidelines say they should stay on four heart medicines for life, but it's unclear if all are still needed. The trial will randomly assign 100 participants…

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping ability will take part. The goal …

This study looks at people whose heart function has improved after heart failure. It tests whether safely reducing certain heart medications can prevent the condition from coming back. About 150 adults will be randomly assigned to either taper their drugs or continue as usual, an…

This study tests whether using portable air filters at home can improve the health and daily function of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with blood pressure and heart-related blood markers. The study involves…

This study tests whether a wearable monitoring system called Sensinel CPM can reduce heart failure-related hospital visits and costs. About 1,200 adults with advanced heart failure will use the system, and their outcomes will be compared to those who do not use it. The goal is to…

This study tests a small sensor placed in the lung artery that sends daily pressure readings to doctors. It aims to help people with mild-to-moderate heart failure (NYHA class II or III) manage their condition and avoid hospital stays. About 1,750 adults will be randomly assigned…

This large study is testing whether taking a daily selenium pill (200 micrograms) can reduce hospitalizations and deaths in people with heart failure. Selenium is a nutrient important for heart health, and many heart failure patients in Northern Europe have low levels. The trial …

This study is testing a device implanted in the heart that both monitors pressure and creates a small opening to ease blood flow. It is for people with chronic heart failure whose heart pumps weakly (ejection fraction 40% or less) and who still have symptoms despite standard trea…

This study tests a device called Heartfelt that uses 3D images to detect early signs of fluid buildup in the legs and feet of people with heart failure. The goal is to see if using this device along with standard care can improve quality of life and reduce hospital visits or deat…

This study follows 150 heart failure patients who receive a device called the Occlutech Atrial Flow Regulator. The device is implanted to help manage symptoms by balancing pressure in the heart's upper chambers. Researchers will track safety and heart-related events for up to thr…

This study tests a nurse-led program that uses simple language and family support to help heart failure patients take their medications as prescribed. The goal is to improve medication adherence, reduce hospitalizations, and enhance quality of life. The study involves 328 patient…

This study tests a personalized stem cell therapy for 10 people with advanced, non-ischemic heart failure who already have a mechanical heart pump (LVAD). After two months of recovery and medication optimization, each participant receives their own stem cells injected into the he…

This study tests whether a quick urine sodium measurement can help doctors better adjust diuretic doses for people with chronic heart failure. About 300 participants will be assigned to either urine-guided treatment or standard care. The goal is to see if this approach improves c…

This study tests a newer pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a wide QRS or high pacing need. The goal is to see which approach better improves quality of life, reduces hosp…

This study tests whether a 6-month program combining exercise training, problem-solving skills, and support from community health workers can improve fitness and health in 210 adults with type 2 diabetes, obesity, and early signs of heart trouble. Participants have low income and…

This study is for people with end-stage heart failure who need a total artificial heart while waiting for a heart transplant. The Aeson device is already approved in Europe, and this research confirms it works well in everyday hospital use. About 95 participants will be followed …

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with home-based exercises, plus coaching and health education. Researchers want to see if this approach helps participant…

This study tests whether blocking certain nerves in the abdomen (splanchnic nerves) can help reduce fluid buildup and improve exercise ability in people with heart failure. About 54 adults with heart failure and reduced pumping function will receive either the nerve block or a pl…

This study tests whether a monthly injection of ziltivekimab can reduce heart failure-related deaths, hospital stays, and urgent visits in people with heart failure and signs of inflammation. About 5,600 participants will receive either the drug or a placebo for up to 4 years. Th…

This study tests whether a daily pill called enavogliflozin (a type of SGLT2 inhibitor) can reduce the risk of major heart problems or worsening heart failure in people who have already had a valve replacement for severe aortic stenosis and also have heart failure with preserved …

This study tests a new medicine called CDR132L to see if it can improve heart structure and function in people with heart failure. About 200 adults aged 40-84 with stable heart failure will receive either CDR132L or a placebo for around 60 weeks. The goal is to measure changes in…

This study tests a drug called sacubitril/valsartan in 220 adults who have an artificial heart valve and heart failure with reduced pumping ability. The goal is to see if the drug can improve heart function by at least one grade on a standard scale. Participants must be 18 or old…

This study tests if a newer pacemaker method (conduction system pacing) combined with a targeted heart ablation works better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. The goal is to reduce deaths, heart fai…

This study tests a new wireless system that helps the heart beat in sync for people with heart failure. About 40 participants will receive the device to see if it is safe and improves heart function. The goal is to offer a leadless option that avoids traditional wires.

This study tests a heart-lung support device (Cardiohelp) in 50 children with severe heart failure to see if it is safe and effective for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. The goa…

This study looks at whether adding protein drinks to the diet can help prevent muscle wasting in people with heart failure. About 120 adults with heart failure and reduced pumping function will be split into three groups: no extra protein, low-dose protein, or high-dose protein. …

This study tests whether using a special body scan called bioimpedance analysis (BIA) can help doctors better manage fluid levels in people hospitalized for worsening heart failure. About 255 participants will be randomly assigned to either BIA-guided treatment or standard care. …

This study tests a 6-month program of supervised exercise, heart risk management, and online support for young cancer survivors (ages 18-45) who have mild heart dysfunction after cancer treatment. The goal is to see if this program improves fitness, heart function, and quality of…

This study looks at whether a small sensor placed in the lung artery (the Cordella PA Sensor System) can help people with chronic heart failure do better than just taking standard medications. Researchers will track about 2,150 patients for two years to see if those with the sens…

This study tests a new medicine called CDR132L to see if it can improve the structure and function of the heart in people with heart failure. About 200 adults aged 40-84 with stable heart failure will be randomly assigned to receive either CDR132L or a placebo. The study lasts ab…

This study compares a heart procedure (pacing and ablation) to standard medication for people with heart failure and permanent atrial fibrillation. About 334 adults with mild-to-moderate heart failure will be followed for 3 years to see which approach better reduces deaths, hospi…

This study tests a 12-week phone coaching program that uses positive psychology and motivational interviewing to help 280 heart failure patients improve their diet, exercise, and medication habits. Participants also receive text messages for up to 24 weeks. The goal is to see if …

This study tests if a single low-dose radiation treatment to the whole heart can improve heart function in people with advanced heart failure who have not responded to standard treatments. About 40 adults with severe heart failure will receive this radiation and be monitored for …

This study tests whether a special heart monitor can help prevent serious problems in people who have survived a severe form of heart failure called cardiogenic shock. The monitor tracks pressure in the artery leading to the lungs. The goal is to see if this monitoring reduces de…

This study tests a new remote monitoring system called SmartSignalHF in over 1,100 adults with heart failure who already have a pacemaker-like device (ICD or CRT-D). The goal is to see if this smarter monitoring can reduce deaths and heart failure-related hospital stays over one …

This study tests whether having a specially trained community paramedic visit people with heart failure at home can reduce hospital stays and emergency visits compared to standard care. About 75 adults with worsening heart failure will take part. The goal is to see if this home-b…

This study tests a special machine that keeps donated hearts cool and oxygenated during transport to the hospital. It includes hearts from both brain-dead and circulatory-death donors. The goal is to see if this method is safe and helps more adults survive after a heart transplan…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (low pumping function) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and improved q…

This study compares two types of heart pacing for people with heart failure: one guided by artificial intelligence (AI) and one using the standard method. The goal is to see if AI helps the heart pump blood more effectively after six months. About 224 adults with weakened hearts …

This study tests a device that automatically tracks leg swelling in people with heart failure. The goal is to catch worsening symptoms early and reduce hospital visits. About 1,500 adults with chronic heart failure and a history of leg swelling will use the device at home for at …

This study tests whether using portable air cleaners at home after a heart failure hospital stay can improve heart health. 400 adults will receive either a real air cleaner or a sham device for 90 days. Researchers will measure changes in a heart stress marker (NTproBNP) and trac…

This study looks at two different ways to pace the heart in people with heart failure who already have a pacemaker and need an upgrade. The goal is to see if a newer method, called conduction system pacing, works as well as the standard method, biventricular pacing. About 66 adul…

This study tests a patch made from stem cells that is designed to strengthen the heart muscle in people with end-stage heart failure who cannot have a heart transplant. About 53 participants will receive the patch to see if it is safe and can improve heart function. The goal is t…

This study tests if a small sensor placed in the lung artery can help doctors manage heart failure better. About 1000 adults with heart failure will be followed for two years. The goal is to see if using the sensor reduces hospital stays and improves survival.

This study tests if a two-step hybrid ablation procedure works better than standard catheter ablation for controlling heart rhythm in people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 adults with enlarged left atria and reduce…

This study tests a new device called SATURN that can repair a leaky mitral valve in the heart without open-heart surgery. It is for people aged 65 and older with severe symptoms who are too high-risk for traditional surgery. The goal is to see if the device is safe and can reduce…

This study tests if colchicine, a drug used for gout, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). The goal is to see if it prevents worsening heart failure, dangerous heart rhythms, and damage seen on scans. About 80 adults with this cond…

This study tests a small implanted device called a CCM that sends gentle signals to strengthen the heart's contractions. It is for 1500 adults with heart failure whose heart still pumps somewhat well (ejection fraction 40-70%). The goal is to see if the device helps them walk far…

This study tests whether a virtual ward — follow-up care via phone or video — can reduce hospital readmissions for people with heart failure. About 346 adults who were recently hospitalized for heart failure will take part. Researchers will compare readmission rates, costs, and q…

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care in their own homes, with a caregiver present for the first 24 hours. T…

This study tests a small, wearable patch that measures heart function from outside the body. The goal is to help doctors adjust heart failure medications remotely and reduce the need for emergency hospital visits. The trial will enroll 200 adults with moderate to severe heart fai…

This study looks at whether adding core muscle exercises (like Pilates) to standard cardiac rehab helps people with heart failure or a recent heart attack recover better. Sixty adults will be split into three groups: core training only, aerobic exercise only, or both combined. Th…

This study tests a program called I-TRANSFER-HF that combines early home health nurse visits and quick outpatient doctor appointments for heart failure patients leaving the hospital. Researchers will compare readmission rates before and after the program is used at hospitals and …

This early-stage trial tests whether donor bone marrow stem cells can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with reduced heart function will receive either standard care alone or standard c…

This study looks at whether people whose heart function has returned to normal after heart failure can safely stop taking beta-blockers, a common heart medication. About 1,300 adults with a history of heart failure and now-normal heart function will either continue or stop their …

This study tests whether using a special heart monitor (pulmonary artery catheter) early in people with cardiogenic shock from heart failure lowers the risk of dying in the hospital. About 400 adults will be randomly assigned to get the monitor or standard care. The goal is to se…

This study compares two types of heart pacing—conduction system pacing and standard biventricular pacing—in 320 adults with heart failure and wide QRS. The goal is to see which method better reduces the risk of death, heart failure hospitalization, or need for a heart transplant …

This study tests whether adding vicadrostat to standard heart failure medication (empagliflozin) helps adults with chronic heart failure and a weak heart pump. About 4200 participants will take either the combination or a placebo plus empagliflozin daily for up to 3.5 years. Rese…

This study looks at 70 people with heart failure, atrial fibrillation (an irregular heartbeat), and a special pacemaker (CRT) that isn't working as well as it should. Participants will be randomly assigned to one of two procedures: ablation of the faulty electrical signals in the…

This study tests whether Empagliflozin (Jardiance), a drug already used for heart failure, can help adults with congenital heart disease whose heart function has recently declined. About 40 participants will take the drug and be monitored for changes in heart pumping strength, ex…

This study tests whether adding vicadrostat to the standard drug empagliflozin helps people with heart failure who have a preserved ejection fraction (LVEF ≥40%). About 6000 adults with symptoms will be randomly assigned to receive either the combination or a placebo plus empagli…

This study tests a device called Aortix, which is a small pump placed in the body to help the heart and kidneys remove excess fluid. It is for people hospitalized with worsening heart failure who still have fluid buildup despite taking strong water pills. About 320 participants w…

This study tests a temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through the skin to help the left ventricle work better. The goal is to see if it's safe and c…

This study tests a new way to manage heart failure using a special scale that tracks fluid buildup. 50 adults with heart failure will use the Bodyport Cardiac Scale at home, and their doctors will get alerts if fluid levels change. The goal is to see if this helps doctors adjust …

This study looks at whether heart failure patients aged 70 and older can do just as well with medication alone as with medication plus an implanted defibrillator (ICD) to prevent sudden cardiac death. About 730 participants with weak hearts will be randomly assigned to one of two…

This study looks at whether ertugliflozin, a diabetes drug, can help people with chronic heart failure manage fluid buildup better than standard treatments. About 60 adults on daily water pills will receive either ertugliflozin, metolazone, or a placebo. Researchers will measure …

This study tests whether a special alert system in heart devices (called HeartLogic) can help doctors manage heart failure better. About 1,428 adults who already have a compatible heart device will be randomly assigned to have the alerts turned on or off. The goal is to see if us…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by a common type of chemotherapy (anthracycline) in women with breast cancer. About 100 participants will take either dapagliflozin or a placebo daily during their chemo. Researchers…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Participants will take antiviral medication (sofosbuvir/velpatasvir) to prevent infection. The goal is to expand the donor pool for heart failure patients awaiti…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the new pump or an existing one to see if the new …

This study looks at a new way to pace the heart called left bundle branch area pacing (LBBAP) for people with conditions like slow heartbeat, heart failure, or atrial fibrillation. About 200 adults will get a special pacemaker lead, and researchers will track safety issues like i…

This study looks at 780 adults with a type of heart attack (NSTEMI) who also have sudden heart failure (fluid in the lungs). Half will get a coronary angiogram (X-ray of heart arteries) within 2 hours of diagnosis, and the other half will wait until their breathing improves. The …

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, aiming to reduce symptoms and hospital stays. Participants are randomly assigned to get th…

This study looks at whether opening narrowed kidney arteries with a small balloon and stent, plus standard medications, works better than medications alone for high-risk patients. About 80 participants with severe kidney artery narrowing and either hard-to-control high blood pres…

This study tests whether two common supplements—coenzyme Q10 and selenium—can lower the risk of heart failure complications. About 4,044 adults with heart failure in Denmark will take either the supplements or placebos for 2-3 years. Researchers will track how many are hospitaliz…

This study compares a targeted drug called acalabrutinib to other standard treatments for adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The main goal is to see if acalabrutinib causes fewer heart-related side effects. About 60 part…

This study compares a new pacing method called His-bundle pacing (His-CRT) to standard biventricular pacing (BIV-CRT) in 120 adults with heart failure and right bundle-branch block. The goal is to see if His-CRT improves the heart's pumping ability more than the standard approach…

This study tests an experimental drug, BMS-986435/MYK-224, in 208 adults with a type of heart failure where the heart pumps normally but is too stiff. The goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo, and…

This study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the risk of heart failure or heart-related death in people with type 2 diabetes, heart disease, and high blood pressure. About 11,300 adults aged 40 and older will take either the combo or a p…

This study tests if briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with heart failure. About 240 adults with heart failure who need a heart catheterization will be randomly assigned to receive either the cuf…

This study tests a newer heart pacing method (left bundle branch pacing) against the standard approach (biventricular pacing) in 60 adults with chronic heart failure and reduced pumping ability. The goal is to see if the newer method improves heart structure, reduces deaths, and …

This study is testing whether a heart medication called sacubitril-valsartan is tolerable and feasible for young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (Stage B) without symptoms. The goal is to see if the drug can help prevent t…

This study tests a hospital-wide treatment plan for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the plan helps doctors identify who will benefit most from a minimally invasive valve repair procedure called MitraClip. …

This study tests whether the drug sotagliflozin can slow kidney function loss in 150 people with type 1 diabetes and moderate to severe kidney disease. Participants will take either the drug or a placebo daily for 3 years, while following a plan to prevent a serious side effect c…

This study tests whether using a heart failure registry to identify patients who need treatment adjustments can improve care. Researchers will screen 500 patients and refer them for medication changes, iron deficiency tests, or device therapy, then compare outcomes with 500 patie…

This study tests whether an artificial intelligence (AI) system, called Willem™, can help doctors detect heart failure more accurately by analyzing electrocardiograms (ECGs). About 1,968 adults with suspected heart failure or at high risk will be randomly assigned to have their E…

This study will check if an artificial intelligence program can analyze a single-lead ECG from devices like the Apple Watch to detect low heart pump function (ejection fraction) and other heart structure problems. About 5000 adults at five hospitals in Taiwan will take part. The …

This study tests a new device called UHF-ECG that measures the heart's electrical signals in more detail than a standard ECG. It aims to see if it can better detect when the heart's lower chambers are not pumping together (ventricular dyssynchrony) in 360 adults with slow heartbe…

This study tests whether artificial intelligence can help doctors in rural and remote Australia use heart ultrasound (echocardiography) to diagnose heart failure and valve disease. About 612 adults over 45 with exercise problems or heart risk factors will take part. The goal is t…

This study is testing whether a new smartphone-based 12-lead ECG device can accurately diagnose heart attacks (STEMI and NSTEMI) compared to standard hospital ECG machines. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to see if the por…

This study tests a new imaging method using a special dye (XTR003) combined with a standard sugar scan (FDG) to see which parts of the heart are still alive in people with heart failure from blocked arteries. About 40 to 60 adults with weak hearts will get this scan before and af…

This study tests a portable device that uses electrical signals to detect early fluid buildup in the lungs of heart failure patients. The goal is to see if the device works as well as standard imaging methods like ultrasound. If successful, it could help patients manage their con…

This study looks at whether using a 7-day heart monitor can help find hidden atrial fibrillation (an irregular heartbeat) in people with high NT-proBNP levels, a sign of heart strain. 4,000 adults without known AF will be split into two groups: one gets the monitor, the other doe…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to help people manage high blood pressure and prevent heart failure. About 364 adults with high blood pressure or other heart risks will receive coaching and support…

This study is for people over 50 who have had COVID-19 and want to protect their hearts. Researchers will test if a combination of heart medications and exercise can prevent heart failure. The goal is to see if this approach helps COVID survivors maintain their fitness and avoid …

This study tests a new way to prevent heart failure in people with type 2 diabetes. Doctors will use a blood test (NT-proBNP) and a risk score to find high-risk patients and then start them on proven preventive medications. The goal is to see if this approach reduces heart failur…

This early study is testing a new device that creates a temporary opening between the upper chambers of the heart to help blood flow more easily, without leaving any implant behind. The goal is to see if the procedure is safe and can improve symptoms in people with advanced heart…

This study tests whether special education from nurses can improve the quality of life and self-care for people with chronic heart failure, while also helping their informal caregivers. About 280 patients and their caregivers will take part. The goal is to see if this approach le…

This study tests whether a 12-week chair yoga program is practical and helpful for 20 heart failure patients aged 55 and older in rural Alabama. Researchers will work with patients and community members to design the program and gather feedback. The goal is to see if yoga can imp…

This study tests whether adjusting the dose of water pills (diuretics) based on urine sodium levels helps people hospitalized with acute heart failure. Researchers will compare a higher urine sodium target to standard care to see if it reduces hospital stays and readmissions. Abo…

This study tests a new way to treat worsening heart failure at home using a small injection of Lasix under the skin. It aims to see if this approach can safely reduce symptoms like fluid buildup and prevent hospital stays. About 100 adults with heart failure and fluid overload wi…

This early study tests a new way to help the heart pump by pacing the diaphragm through a vein near the heart. Ten heart failure patients already scheduled for a standard heart device will also receive this temporary pacing. The goal is to see if it's safe and can improve heart f…

This study looks at whether simple cooling methods, like wetting the skin or wearing a water-soaked T-shirt, can help people with heart failure avoid dangerous overheating during heat waves. About 88 adults with and without heart failure will sit in a hot, dry room while their bo…

This study looks at whether personalized support from a sport and health professional can help people with heart failure stay physically active for a full year after completing a cardiac rehab program. About 90 adults with stable heart failure will either receive this tailored fo…

This study looks at whether starting a special exercise and breathing program early in the hospital helps people with acute decompensated heart failure. About 40 adults who are stable enough will take part. The goal is to see if this therapy improves their ability to walk, breath…

This study tests whether a low dose of colchicine, a drug used for gout, can improve exercise capacity in people with a type of heart failure called HFpEF who also have signs of inflammation. About 60 participants will receive either colchicine or a placebo for 3 months. Research…

This study looks at whether a home-based exercise program, guided by a smartphone and activity tracker, can help people who have a new HeartMate 3 heart pump become more active, stronger, and have a better quality of life. About 100 adults who recently received the pump will eith…

This study tests whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will do 40-60 minutes of exercise (like brisk walking or cycling) five times a week for eight weeks. Researchers wi…

This study tests whether a drug called anakinra can make the heart more sensitive to inotropes (medications that strengthen heart contractions) in people with advanced heart failure. By reducing inflammation, doctors hope to lower the dose of inotropes needed, which may decrease …

This study tests whether a tablet called sotagliflozin can improve quality of life for people with type 1 diabetes who also have heart failure. About 320 adults in the UK will take either the drug or a placebo daily for 4 months. The goal is to see if the drug reduces symptoms li…

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if the right amount of ketones can be delivered to the blood. Only 12 participants with very weak hearts will be enrolle…

This study looks at whether eccentric resistance training (a type of exercise that focuses on lengthening muscles) can improve heart function and exercise ability in people with stable chronic heart failure. About 84 participants will be assigned to either eccentric training or s…

This study tests a new drug called NNC0537-1482 in 36 adults with heart failure to see if it is safe and how the body processes it. Participants are randomly assigned to receive either the drug or a placebo (inactive dummy) for up to 64 days. The goal is to check for side effects…

This study tests a 6-week WeChat-based program called SOCIAL_HF for people aged 60+ with heart failure who feel socially frail. Participants join weekly video chats and do daily check-ins. Researchers want to see if it improves social connections, self-care, and support compared …

This study looks at whether listening to music during exercise testing can improve how well the heart and lungs work in people with heart failure. About 40 adults will do two exercise tests—one with music and one without—so researchers can compare results like oxygen use and brea…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who had chemotherapy for breast cancer. Chemo can weaken the heart and reduce physical ability, but exercise might help. Researchers will compare a structured exercise pr…

This study tests whether ziltivekimab, an experimental drug, can improve symptoms and daily function in people with heart failure who also have signs of inflammation. About 680 participants will receive either the drug or a placebo for up to 16 months. The main goal is to see if …

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in people aged 50 and older with heart failure and sarcopenia (age-related muscle loss). Researchers will also explore how the program affects symptoms and qu…

This study tests a 12-week smartphone-assisted cardiac rehabilitation program for adults with stable heart failure. Participants use a phone app guided by a case manager to exercise safely at home. The goal is to see if this approach improves exercise capacity and quality of life…

This study is testing a phone-based system that helps people with heart failure monitor their symptoms and get coaching on how to manage them at home. The goal is to see if this system improves patients' ability to care for themselves. The study will enroll 50 adults with heart f…

This pilot study tests a simple tool called 'Wake and Weigh' that helps older adults with heart failure track their weight daily. The goal is to see if this easy habit improves their quality of life and ability to manage their condition at home. About 42 participants will use the…

This study tests a digital program called TPA4You that uses a Fitbit to help older adults (50+) who care for a family member with heart failure become more physically active. The goal is to see if the program is practical and can improve daily activity, reduce sitting time, and e…

This study tests whether taking potassium nitrate (a natural salt) can help people with heart failure exercise better and feel stronger. Researchers will give 75 adults either the nitrate or a placebo daily for 6 weeks, measuring muscle power and oxygen use during treadmill tests…

This study tests whether personalized text messages can help older adults (age 50+) with heart failure improve their self-care, like taking medications correctly and following a heart-healthy diet. Participants will be randomly assigned to receive either usual care or usual care …

This study tests whether training the muscles used for breathing can improve exercise ability and blood flow in people with heart failure. Researchers at Mayo Clinic will enroll 68 adults who are already on standard heart failure medications. Participants will undergo inspiratory…

This study tests whether a sensor-controlled digital game can motivate adults with heart failure to regularly check their weight and stay active. About 200 participants will either get the game plus sensors or just the sensors alone. The goal is to see if the game helps people st…

This study tests a 12-week telephone program where veterans with heart failure work with a nurse to solve problems related to their health. The goal is to improve self-care, reduce symptoms of heart failure, and ease depression and anxiety. Researchers will follow participants fo…

This study tests whether adjusting a pacemaker to a personalized, optimal heart rate can improve symptoms and quality of life in people with heart failure and a slow heartbeat. About 106 participants will be randomly assigned to either the new optimized pacing strategy or standar…

This study looks at whether using a simple bedside ultrasound (POCUS) can help doctors better manage fluids in patients hospitalized with worsening heart failure. About 66 adults will be randomly assigned to either ultrasound-guided care or standard care. The main goal is to see …

This study looks at whether a cardiac tele-rehabilitation program done at home can improve exercise capacity in adults with chronic heart failure. Participants will use wearable devices and a remote monitoring platform for an 8-week program. Researchers will compare their progres…

This study tests whether taking L-Carnitine by mouth can improve symptoms, heart function, and quality of life in people with heart failure who also have kidney problems. About 20 adults will take the supplement and be monitored for side effects and benefits. The goal is to see i…

This study tests whether mindfulness training can help people with both heart failure and mild memory problems improve their self-care and thinking skills. About 176 adults will take part. The goal is to see if learning to focus on the present moment helps them manage their condi…

This study uses a special MRI technique to look at the microscopic structure of the heart muscle in people at risk for heart failure. Researchers want to understand how heart muscle fibers change over time in conditions like heart attack and thickened heart walls. The goal is to …

This study looks at electrical signals in the heart during different pacing strengths and body positions in 75 adults who already have a special type of pacemaker called LBBAP. The goal is to gather data that could help create a smarter algorithm to detect when the pacemaker is c…

This study looks at how heart rate and pumping strength are linked to metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to study these connections. The goal is to better understand heart-mu…

This study looks at whether a person's genetic makeup can predict how well they respond to beta-blocker medication for heart failure. Researchers will enroll 10 adults with mild heart failure and use a polygenic score to guide treatment. The main goal is to measure changes in hea…

This study aims to create a computer-based tool that predicts which cancer patients are at risk of heart damage from certain chemotherapy drugs. Researchers will follow 600 patients in France for one year, collecting data to train a machine learning model. The goal is to help doc…

This study aims to understand why obesity increases the risk of a specific type of heart failure called HFpEF, where the heart becomes stiff. Researchers will follow 250 people with obesity for two years, using heart ultrasounds and blood tests to detect early signs of heart prob…

This study looks at 26 adults with severe heart failure and cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure markers of inflammation and blood vessel damage over time to better understand how the body reacts during …

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, heart failure, or high blood pressure. Researchers will measure blood flow and blood pressure before and after exercise in healthy volunteers and patients. Th…

This study looks at whether an implantable heart device (ICD) helps people with non-ischemic cardiomyopathy—a type of heart failure not caused by blocked arteries—live longer. About 2,500 participants will be split into two groups: one gets the device, the other does not. The goa…

This study looks at whether removing extra fluid from the body helps improve sleep apnea in adults hospitalized with heart failure. About 50 participants will wear a sleep monitor before and after fluid removal. Researchers will measure changes in sleep apnea severity and see if …

This study looks at how well a smart alert system works for people with heart failure who have a special heart device. The system monitors the heart and can warn doctors up to 42 days early if heart failure might get worse. About 100 patients in Italy will take part, and research…

This study explores how the brain processes chronic breathlessness in people with advanced cancer, COPD, or heart failure. Researchers will use brain scans (fMRI) and virtual reality to see if different diseases cause different breathlessness patterns. The goal is to learn if cur…

This study looks at what builds up on the Impella heart pump after it has been used in people with heart failure. Researchers will analyze deposits and proteins on the pump and connect them to patient health data. About 200 adults who have used the pump for several days will take…

This study looks at how well the right side of the heart works with the lungs in people with heart valve problems. Researchers will use a thin tube (catheter) to get precise measurements and compare them to standard imaging tests like echocardiograms. The goal is to see if simple…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with chronic obstructive pulmonary disease (COPD). Researchers will follow 200 hospitalized COPD patients aged 50 to 70 to track their health, including deaths, hospital readmiss…

This study looks at fat cells around the heart arteries in 60 patients getting a heart transplant. Researchers want to see if the size of these fat cells is linked to heart disease. The goal is to learn more about how fat tissue affects artery health.

This study looks at how often blood vessel problems happen after a kidney transplant and whether a balloon treatment can help. Researchers will follow 60 kidney transplant patients in Denmark to check kidney function and blood pressure. The goal is to find better ways to diagnose…

This study tests whether pharmacist-led medication adjustments and simple educational materials can help heart failure patients with limited access to care get the right medications. About 40 adults with heart failure and reduced ejection fraction will be randomly assigned to eit…

This study looks at how physical activity levels change with the seasons in people with heart failure who have a cardiac implantable electronic device (like a pacemaker). Researchers will track 24 participants over a year using a wrist-worn activity tracker and questionnaires. Th…

This study aims to create a tool that helps doctors predict which patients with dilated cardiomyopathy (a condition where the heart becomes enlarged and weak) are at highest risk for serious problems like heart failure, dangerous heart rhythms, or sudden cardiac death. Researcher…

This study looks back at medical records of 100 children with a rare genetic condition called RASopathy that causes severe heart thickening and heart failure. The goal is to collect detailed health and genetic information to create a comparison group for future drug trials. No ne…

This study reexamines 1,400 adults originally part of a large Swedish health study to identify risk factors for heart, lung, and liver diseases. Participants undergo advanced imaging, blood tests, and questionnaires. The goal is to better understand how conditions like coronary a…

This study looks at how heart failure might cause changes in brain volume. Researchers will use MRI scans to measure brain structures in 100 adults with heart failure and compare them to people with normal heart function. The goal is to understand the connection between heart hea…

This study tests an AI tool that analyzes heart ultrasound images to find undiagnosed heart failure in people with type 2 diabetes. Researchers will see if giving doctors these AI results helps them prescribe protective medications. About 800 adults with diabetes but no known hea…

This study looks at how cancer patients with heart failure feel day-to-day. Researchers will ask 100 adults about their symptoms and quality of life using simple questionnaires. The goal is to better understand the challenges these patients face, not to test a new treatment.

This study follows 2,000 people with chronic heart failure to see if their daily step counts and activity levels are linked to future heart problems or death. Participants wear a pedometer or smartwatch and answer activity questionnaires every six months. The goal is to learn how…

This study looks at 160 people with heart failure who are scheduled for coronary artery bypass surgery. Researchers want to see if a substance in the blood called GDF-15 can help predict serious heart problems, like heart attacks or hospital stays, in the year after surgery. Part…

This study looks at why some people with heart failure don't respond well to diuretics (water pills). Researchers will give participants either ammonium chloride or a placebo to see how it affects sodium handling in the kidneys. The goal is to better understand the mechanisms beh…

This study tests whether a nutritional shake given before LVAD surgery can improve gut health and reduce inflammation in heart failure patients. About 50 hospitalized adults awaiting LVAD implantation will drink the shake and provide blood and stool samples. Researchers will comp…

This study aims to understand why some heart failure patients choose to join programs like PRADO-IC (home care support) or telemedicine after leaving the hospital. Researchers will follow 700 adults hospitalized for heart failure to see what factors—like social, cultural, or geog…

This study is for adults hospitalized with worsening heart failure. Researchers will use an early heart ultrasound to see if certain measurements can predict who will need to return to the hospital or face serious complications. The goal is to help doctors better identify high-ri…

This study will test if wearable monitors can safely track heart failure in 100 children aged 8-18 at home instead of in the hospital. The monitors measure heart rate, breathing, and activity, sending data to doctors to spot early warning signs. The goal is to see if this approac…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part, and researchers will track how well the screening works and if it leads to better…

This study is testing whether a robot-assisted remote heart ultrasound (echocardiogram) can be as accurate as a standard in-person ultrasound for people with heart failure. About 50 adults in Guadeloupe will get both types of scans, and researchers will compare the results. If su…

This study looks at how a 12-week exercise program changes proteins in the blood of people with heart failure. Researchers want to find which proteins improve with exercise, so they can eventually create a medicine that mimics those benefits. About 90 adults with heart failure wi…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to learn how to better predict and prevent these complic…

This study is for people with heart failure who do not have a pacemaker or defibrillator. Researchers will use a small implanted device called BIOMONITOR IV to track heart rhythms and other body signals over time. The goal is to learn how often irregular heartbeats happen and to …

This study tests a new type of PET/CT scan (68Ga-FAPI) to see if it can find active scarring in the hearts of 30 people with heart failure. The goal is to compare this scan with standard MRI to see if it can detect early or ongoing fibrosis. This is an observational study, not a …

People with serious mental illness often have undiagnosed physical problems like heart disease, diabetes, or cancer. This study adds routine health checkups to psychiatric clinics to see if they catch these hidden conditions better than usual care. About 2,800 adults with psychot…

This study is looking at whether people with psoriasis have a higher risk of heart disease. Researchers will follow 1,000 adults with psoriasis, using heart scans and blood tests to find early warning signs. The goal is to better understand the link between psoriasis and heart pr…

This study is creating a large collection of blood, tissue, and health information from 15,000 people, including those with heart conditions like aortic aneurysm and heart failure, as well as healthy volunteers. The goal is to provide researchers with a valuable resource to bette…

This study is creating a registry of 101 adults with chronic heart failure to collect detailed health information over time. Researchers will track how the disease progresses and measure survival rates at 1, 5, and 10 years after diagnosis. No new treatments or medications are be…

This study looks at tiny structures inside heart cells called mitochondria, which help produce energy. Researchers want to see if problems with these structures are linked to worse heart failure outcomes. About 45 to 60 people with heart failure and blocked arteries will give sma…

This study looks at how social factors like income, insurance, and community distress affect the early diagnosis and treatment of heart failure. Researchers will follow 1,000 adults at risk for heart failure to see if these factors lead to differences in detection and medication …

This study looks at why some people with heart failure don't respond well to diuretics (water pills). Researchers will test different drug combinations in 50 adults to see if they can improve how the kidneys remove excess fluid. The goal is to understand the body's resistance mec…

This study collects heart electrical activity (ECG) data from 1000 adults aged 45-80 with heart failure to build a library for developing future monitoring tools. Participants undergo standard clinical assessments and share their experiences with heart failure care. The goal is t…

This study is for people with a slow heartbeat (bradycardia) or heart failure who are already scheduled to get a pacemaker or similar device. Researchers will take extra measurements during the implant procedure to see how a special type of pacing called His bundle pacing affects…

This study looks at how the drug dapagliflozin affects the heart and kidneys in 103 adults with advanced heart failure who are waiting for a heart transplant. Researchers will measure a protein called suPAR in the blood to track changes in kidney health over 6 months. The goal is…

This study is testing a non-invasive thumb sensor that measures oxygen levels in tissue to see if it can help assess heart failure severity in children. About 130 participants under 25 with stable heart failure will have their thumb oxygen measured at rest and during a brief bloo…

This study looks at how leg artery disease (LEAD) might affect the heart's pumping ability. Researchers will use ultrasound imaging to measure heart function in 162 participants with and without LEAD. The goal is to find connections between heart strain, metabolism, and organ dam…

This study looks at whether doing intense exercise before a blood test can make the test better at finding early signs of heart transplant rejection. Researchers will test 27 heart transplant recipients. The goal is to see if exercise changes the levels of DNA from the donor hear…

This study is a registry that will follow 4000 adults in the UK who have been newly diagnosed with heart failure and have a weak heart pump (ejection fraction below 50%). Researchers will collect information on hospital stays, deaths, and what treatments patients receive. The goa…

This study tests a program called FRAME that helps heart failure patients talk about mental health with their doctors and family. About 7,300 adults with heart failure or at risk for it will take part. The goal is to see if the program makes it easier for patients to get mental h…

This study will use wearable digital patches to collect heart data from 5,000 adults with conditions like heart failure, high blood pressure, and heart valve disease. The goal is to observe how these conditions change over time for research purposes. Participants wear a sensor pa…

This study is testing whether a simple chatbot questionnaire can help spot early signs of heart failure getting worse. Researchers will ask 120 people with heart failure to regularly answer questions about their health via a chatbot. The goal is to see if changes in their answers…

This study is testing a small, skin-based device that records heart signals in people with heart failure. The goal is to find early warning signs that a patient's condition is getting worse, so doctors can step in sooner. About 70 adults hospitalized for heart failure will wear t…

This study looks at why some people tolerate ventricular tachycardia (a fast, abnormal heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart arteries of 70 people already scheduled for a heart catheter procedure. They want to see if…

This study aims to make sure lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone disorders are accurate and give consistent results. It will involve up to 100 healthy volunteers and people with these conditions, aged 18 to 100. The …

This study looks at whether a low-sodium (cardiac) diet is truly needed for better health in people who have had heart failure. Researchers will track 500 adults hospitalized for heart failure to see how sodium intake affects hospital stay length and readmission within 30 days. T…

This study tests whether an AI tool can detect early signs of fluid buildup in the lungs by analyzing changes in a person's voice, cough, and breathing sounds. Researchers will enroll 250 adults with advanced heart failure to develop and refine the AI algorithm. The goal is to gi…

This study aims to improve how doctors predict heart disease risk by using a special MRI technique called T1 mapping. Researchers will scan 6000 adults without known heart disease, including people with Long COVID, to find early signs of heart problems. The goal is to better iden…

This study looks at whether a special breathing technique (negative pressure ventilation) can help the right side of the heart work better in people who already have a left ventricular assist device (LVAD), a type of heart pump. About 30 adults who recently got an LVAD and are st…

This study aims to improve how we detect and understand heart disease using a new type of MRI that looks at the heart's microscopic structure. Researchers will compare these advanced scans with standard tests and blood work in 1,000 adults, both healthy volunteers and those with …

This study is testing a risk calculator that predicts who might develop heart failure before they have any symptoms. Researchers will use it in GP practices across Greater Manchester with 600 adults aged 50 and over who have conditions like diabetes or high blood pressure. The go…

This study is observing how well Medtronic heart devices (like pacemakers and defibrillators) work over time in 20,000 people with heart rhythm problems or heart failure. Researchers are tracking device survival and complications to improve future products. Participants must alre…

This study looks at how a specific cell signaling pathway (BMPR2-activin) contributes to pulmonary hypertension in people with heart failure. Researchers will follow 150 patients for one year, using blood tests, heart imaging, and tissue samples to understand the disease better. …

This study looks at whether people with stable heart failure whose heart function has improved can safely stop taking a type of medication called a mineralocorticoid antagonist (MRA). Researchers will compare those who stop the drug (taking a placebo instead) with those who conti…

This study aims to better understand heart failure by using advanced testing (multi-omics) to identify people at higher risk for serious problems like hospitalization or death. Researchers will also test a remote monitoring program to help doctors optimize medications. The study …

This study explores whether a smartphone app that records your voice each day can help detect changes in lung artery pressure in people with heart failure who already have an implanted pressure sensor. About 60 adults across Germany and the US will record a short passage daily fo…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease and early signs of heart failure. Researchers will measure heart strain, oxygen use during exercise, and blood markers. About 60 adults with mode…

This study is a registry that will follow about 320 people with heart failure who receive the WiSE System, a device that helps the heart pump better. The goal is to see how safe and effective the device is in everyday use by tracking serious side effects and heart function improv…

This study will follow 30,000 people aged 60 and older in Qujiang, China, who have chronic heart conditions like high blood pressure, heart failure, or atrial fibrillation. Researchers want to see if a program combining medication, lifestyle advice, education, and regular check-u…

This study looks at heart tissue from people with a type of heart failure called HFpEF. Researchers will take tiny samples of heart muscle during a routine procedure to find changes that could lead to new treatments. About 180 adults with heart failure symptoms will take part.

This study uses special MRI scans to see how the heart's structure and energy use change after bariatric surgery or cardiac rehab. Researchers will scan 150 adults before and 6-12 months after these treatments. The goal is to understand how these metabolic interventions affect he…

This study looks at whether adding a medicine called acetazolamide helps people with heart failure who still have fluid buildup despite standard treatments. Researchers will measure how much salt and water the body gets rid of over 24 hours. The study involves 64 adults admitted …

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions fo…

This study tests a non-invasive imaging method to find the best pacemaker settings for people with heart failure. About 25 participants will have their heart activation times measured under 16 different device settings. The goal is to improve how well the pacemaker works, but thi…

This study compares two approaches to fluid intake in people with heart failure: drinking freely versus limiting fluids. The goal is to see if drinking freely is safe and can improve quality of life and reduce thirst. About 326 adults with heart failure will participate, and rese…

This study looks at 140 adults with heart failure who are admitted to the hospital. It compares those who were already taking a medicine called ARNI before coming in to those who were not. Researchers will check medical records for heart and kidney events and hospital stay length…

This study looks at whether monitored exercise during cardiac rehabilitation can help veterans with heart failure with preserved ejection fraction (HFpEF). Researchers want to see if the facility can support a larger study and if exercise shows clear benefits without harm. Partic…

This study tests a new, non-invasive method to measure how well the heart and blood vessels work in adults with and without heart failure. Participants will have a single 20-minute visit where they squeeze a handgrip device while wearing sensors. The goal is to see if this simple…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at how diabetes changes the way heart cells use energy, which may lead to heart failure. Researchers will examine heart tissue and use imaging tests in 500 adults with heart failure, with or without type 2 diabetes. The goal is to better understand the disease an…

This study will follow 10,000 people with heart conditions (like heart failure, heart attack, or bypass surgery) who are going through cardiac rehab at a clinic in Davos, Switzerland. Researchers will collect health data, blood samples, and patient reports to learn what helps peo…

This study is not testing any new drugs. Instead, it brings together doctors, nurses, pharmacists, and patients who have recently been in the hospital for heart failure. They will discuss which treatments to study in a future trial, what doses to use, and how to measure success. …

This study follows 400 adults with severe heart failure who receive a mechanical heart pump (ventricular assist device). Researchers will track survival rates and complications over five years to understand how well these devices work in real-world settings. The goal is to gather…

This study is testing whether monitoring a blood marker called sST2 can help doctors better manage heart failure and reduce repeat hospital visits. Researchers will compare costs and quality of life between patients whose treatment is guided by sST2 levels and those receiving usu…

This study is creating a live registry to track heart failure patients across the Yale New Haven Health System. Researchers will monitor hospitalizations and use of recommended treatments in up to 40,000 participants. The goal is to better understand and improve heart failure car…

This study looks at why standard heart failure medications may not completely block the hormone aldosterone, which can affect salt and water balance. Researchers will give 20 people with stable heart failure either the drug spironolactone or a placebo, then measure how their bodi…

This study looks at whether a structured education program helps heart failure patients and their families learn about the condition, self-care, and emergency signs. About 1,000 adults hospitalized or treated for heart failure will take part. The program includes a one-hour sessi…

This study looks at heart failure, a condition where the heart can't pump enough blood, causing shortness of breath and tiredness. Researchers will collect data from 1,000 adults, including heart images and blood tests, to find different types of heart failure. The goal is to hel…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…