Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New hybrid heart procedure aims to tame stubborn AFib in heart failure patients

NCT ID NCT05411614

Disease control Sponsor: St. George's Hospital, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two procedures. The main goal is to see which method better prevents the return of atrial arrhythmias without the need for long-term medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Convergent hybrid ablation (epicardial and endocardial ablation) versus standard catheter ablation
What this could lead to
If successful, this hybrid approach could offer better control of atrial fibrillation in patients with heart failure, potentially improving heart function and quality of life.
What could go wrong
This is a relatively small, early-stage trial (120 participants) comparing two invasive procedures. The hybrid ablation is more complex and may carry higher risks, and it is not yet proven to be superior.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Persistent or Long-standing Persistent AF * Dilated left atrium (at least moderately dilated) * Suitable for either procedure * LVEF \< 50% Exclusion Criteria: * Not yet optimised from a medical or lifestyle perspective for AF or heart failure * Unable to provide written consent * Previous open-heart surgery * Active infection, oesophageal ulcer stricture or oesophageal varices * Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable) * Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation * Severe valvular heart disease * Unstable coronary artery disease * Uncontrolled ventricular arrhythmia * Heart attack or stroke within the last 90 days * Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months * Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Atrial arrhythmia are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

atrial fibrillation heart failure left ventricular failure persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial arrhythmia Atrial fibrillation Atrial fibrillation, persistent Heart failure Left ventricular (LV) systolic dysfunction Persistent atrial fibrillation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    5 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ashford & St Peters Hospital NHS Trust

    RECRUITING

    Chertsey, United Kingdom

  • Cromwell Hospital

    ACTIVE_NOT_RECRUITING

    London, United Kingdom

  • Epsom General Hospital

    RECRUITING

    Epsom, United Kingdom

  • Royal Surrey County Hospital

    RECRUITING

    London, United Kingdom

  • St Anthonys Hospital

    ACTIVE_NOT_RECRUITING

    London, United Kingdom

  • St Georges University of London

    RECRUITING

    London, United Kingdom

    Contact Email: •••••@•••••

  • St Georges at Kingston Hospital

    RECRUITING

    London, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.