PERSISTENT ATRIAL FIBRILLATION

This study is testing the safety and effectiveness of the Volt PFA System, a balloon-based device that uses electrical pulses to treat atrial fibrillation (AFib). About 300 people with paroxysmal or persistent AFib will be enrolled. The main goal is to see how well the system sto…

This study tests a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who have already had one ablation procedure. The treatment uses a special system called FARAPULSE to deliver energy to the heart and block faulty signals. About 376 adults…

This study tests a new mapping system (CoreMap) that helps doctors find and treat the source of persistent atrial fibrillation (AFib) during a standard ablation procedure. About 245 adults with persistent AFib will take part. The main goals are to check safety and see if the syst…

This study tests new energy waveforms from the FARAPULSE system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with either occasional or persistent AFib will receive a minimally invasive procedure to isolate faulty electrical signals in the heart. T…

This study compares two heart procedures for people with persistent atrial fibrillation (a type of irregular heartbeat). One group gets the standard treatment (isolating the pulmonary veins) plus an extra set of ablation lines in the heart, while the other group gets the standard…

This study looks at whether a heart procedure called catheter ablation can slow or improve memory loss in people with mild cognitive impairment and persistent atrial fibrillation (an irregular heartbeat). About 120 adults aged 60-80 will be randomly assigned to either medication …

This early study tests a new catheter that changes shape to better treat persistent atrial fibrillation (a type of irregular heartbeat). The catheter uses electrical pulses to scar small areas in the heart and block faulty signals. About 40 adults with this condition will receive…

This study tests if using a special energy device (radiofrequency ablation) during planned open-heart surgery can safely stop long-lasting atrial fibrillation (AFib). About 160 people with persistent AFib who need heart surgery for other reasons will take part. The goal is to see…

This study tests if a two-step hybrid ablation procedure works better than standard catheter ablation for controlling heart rhythm in people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 adults with enlarged left atria and reduce…

This study tests a new catheter system (Sphere-9 and Affera) for a repeat heart ablation procedure in people whose atrial fibrillation (AFib) came back after a first ablation. About 400 adults with recurrent symptomatic AFib will be treated and followed for 12 months. The goal is…

This study is a registry that will track the safety and success of a procedure called pulsed field ablation (PFA) for treating atrial fibrillation (an irregular heartbeat) in 275 patients who are racial or ethnic minorities. The procedure uses FDA-approved catheters to correct th…

This study compares two treatments for persistent atrial fibrillation (AF), a heart rhythm problem. One group gets catheter ablation (a procedure to destroy tiny areas causing the irregular rhythm), the other gets a controlled electric shock (cardioversion) to reset the heart. Re…

This study tests whether adding a kidney nerve treatment (renal denervation) to a repeat heart ablation procedure can better prevent atrial fibrillation from coming back. It involves 250 adults with high blood pressure who need a second ablation. Participants are randomly assigne…

This study compares two doses of the heart medication amiodarone in people with persistent atrial fibrillation (an irregular heartbeat) after they receive an electrical shock to restore normal rhythm. The goal is to see if a lower daily dose (100 mg) works as well as the standard…

This study compares three different ablation techniques for people with persistent atrial fibrillation (a type of irregular heartbeat). Using a special catheter that can switch between two energy types, doctors will see if adding extra ablation spots improves results. Sixty adult…

This study tests a new device called FARAFLEX that uses pulsed field ablation to treat people with persistent or occasional atrial fibrillation (an irregular heartbeat). About 250 adults will receive either the new catheter or a standard one to see if it safely and effectively cr…

This study tests whether Qidong Yixin Granules, a Chinese herbal medicine, can lower the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to take either …

This study looks at whether a week of exercise (moderate or high intensity) changes symptoms of atrial fibrillation compared to a week of rest. It includes 36 adults aged 40+ with paroxysmal or persistent AF who have had symptoms recently. The main goal is to see if a larger stud…

This study is testing a new, paddle-shaped catheter designed to map abnormal heart rhythms (arrhythmias) in people with conditions like atrial fibrillation or ventricular tachycardia. About 60 participants will undergo a standard heart-mapping procedure using this investigational…