ATRIAL FIBRILLATION

This study compares two blood thinners—apixaban and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents another stroke or death. About 700 adults will tak…

This study tests whether the drug colchicine can prevent atrial fibrillation (a type of irregular heartbeat) in people recovering from heart bypass surgery. Researchers will compare 70 patients who receive colchicine plus a special surgical technique with 70 patients who receive …

This study looks at whether adding a blood thinner to standard anti-clotting medication can prevent strokes and other blood clots in people who develop a new irregular heartbeat after heart bypass surgery. About 3,200 adults who had bypass surgery and then a lasting or repeated e…

This study is testing the safety and effectiveness of the Volt PFA System, a balloon-based device that uses electrical pulses to treat atrial fibrillation (AFib). About 300 people with paroxysmal or persistent AFib will be enrolled. The main goal is to see how well the system sto…

This study tests whether a catheter-based procedure to close a small pouch in the heart (the left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are still at high risk despite taking blood thinners. About 4,000 participants will be ran…

This study tests if placing small filters in the carotid arteries (the main blood vessels in the neck) can catch blood clots before they reach the brain and cause a stroke. It involves 2,000 people with atrial fibrillation who have already had a stroke and are taking blood thinne…

This study follows about 1,950 people with atrial fibrillation (an irregular heartbeat) who are getting a procedure called PulseSelect PFA. The procedure uses energy to fix the heart's electrical signals. Researchers want to see how well it stops irregular heartbeats and if it ca…

This study follows 580 people with atrial fibrillation (AFib) who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will check how many patients stay free of AFib and avoid serious side effects over 3 years.…

This early study tests a new device that uses nanosecond electric pulses to treat atrial fibrillation (an irregular heartbeat) during heart surgery. About 30 adults aged 18-85 with a history of atrial fibrillation will receive the treatment. The goal is to see if the device can s…

This study looks at whether a telemedicine program can help vulnerable heart failure patients who cannot attend regular rehab. About 300 patients, along with their doctors and home caregivers, will use video calls and chat to coordinate care. Researchers will compare hospital rea…

This study looks at whether blood thinners can prevent strokes in people who had a short episode of atrial fibrillation (irregular heartbeat) triggered by stress, such as after surgery or a serious illness. About 2,270 adults with additional stroke risk factors will either take a…

This study compares two ways to perform a heart procedure called pulmonary vein isolation (PVI) for people with atrial fibrillation (AFib). One method uses only X-ray guidance, while the other adds a special mapping system. The goal is to see if the mapping system helps keep the …

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (AF), a common heart rhythm problem. Half of the 556 participants will receive the standard treatment, while the other half will get a personalized procedure that targets the specifi…

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (an irregular heartbeat) while people are already having heart surgery for other reasons. About 135 adults aged 18-85 with a history of atrial fibrillation will take part. The goal is to …

This study follows 250 people with atrial fibrillation who had a procedure to close a small pouch in the heart (the left atrial appendage) to lower stroke risk. The goal is to see how well the closure works over 5 years, especially for those who cannot take long-term blood thinne…

This study tests a digital app called VIRTUES that helps people with heart conditions manage their health from home. The app provides personalized recommendations for medications, diet, exercise, and more. Researchers will enroll 2,000 patients to see if the app is easy to use an…

This study tests a new device called CLAAS that closes a small pouch in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1,600 participants will be randomly assigned to get either the new device or an existing one, and they will be f…

This study compares two common blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults with newly diagnosed AF will be randomly assigned one of the two drugs and monitored for blee…

This study tests if a newer pacemaker method (conduction system pacing) combined with a targeted heart ablation works better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. The goal is to reduce deaths, heart fai…

This study tests whether doing two heart procedures at once—fixing faulty electrical signals and closing a small heart pouch—can prevent future strokes better than standard treatments in people who recently had a stroke due to atrial fibrillation. About 240 participants will be r…

This study is testing whether a drug called Enavogliflozin, currently used for diabetes, can help prevent atrial fibrillation (an irregular heartbeat) from coming back after a catheter ablation procedure in people who also have heart failure. About 390 adults aged 19 to 85 will b…

This study looks at whether finding and treating obstructive sleep apnea can help people with atrial fibrillation (an irregular heartbeat). About 209 adults with AF will use a home sleep test and a Fitbit smartwatch to track their heart rhythm. If sleep apnea is found, they will …

This study compares a heart procedure (pacing and ablation) to standard medication for people with heart failure and permanent atrial fibrillation. About 334 adults with mild-to-moderate heart failure will be followed for 3 years to see which approach better reduces deaths, hospi…

This study tests whether starting comprehensive heart rhythm control early after a stroke caused by atrial fibrillation can prevent future strokes, heart failure, or heart attacks. About 1,700 adults who had a stroke in the last month and were recently diagnosed with atrial fibri…

This study looks at 86 people with atrial fibrillation who need a procedure to control their heart rate. After the procedure, they will get either a standard pacemaker or a new type that paces the heart's natural conduction system. The goal is to see which method better prevents …

This study is testing a new device that uses short bursts of energy (pulsed field ablation) to treat atrial fibrillation, a common heart rhythm problem. About 175 people with a history of AF will receive the procedure to see if it is safe and works well. The device maps the heart…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and bleeding in the brain after emergency treatment. About 240 adults will be randomly assigned to start blood thinners early or later. The goal is to find the safest tim…

This study tests an experimental oral drug, PKN605, to see if it can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. About 165 adults with a history of atrial fibrillation will receive either the drug or a placebo. The main goal is to…

This study looks at people with atrial fibrillation who get a procedure to close a part of the heart (left atrial appendage) to lower stroke risk. Instead of taking standard blood thinners for life, participants take a lower dose of apixaban for just 3 months and then stop all bl…

This study tests a new system that uses heat to create small scars in the heart to block faulty electrical signals causing atrial fibrillation (an irregular heartbeat). About 150 adults with this condition who haven't improved with medication will be treated. The goal is to see i…

This study tests if people with atrial fibrillation (AFib) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with AFib and low-to-moderate stroke risk will be randomly assigned to either standard daily blood thinners …

This study looks at whether doing a heart procedure called ablation early after diagnosis can prevent strokes, heart-related deaths, and heart failure hospitalizations in people with atrial fibrillation and multiple other health issues. About 2,300 participants will be randomly a…

This study tests whether ondansetron, a drug used to prevent nausea in cancer patients, can help people with atrial fibrillation (Afib). Afib is a common irregular heartbeat that can lead to stroke and other serious problems. The researchers will give 80 people either ondansetron…

This study tests if a two-step hybrid ablation procedure works better than standard catheter ablation for controlling heart rhythm in people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 adults with enlarged left atria and reduce…

This study tests whether tirzepatide, a weight-loss medication, can reduce the burden of atrial fibrillation (an irregular heart rhythm) in 100 adults with obesity. Participants will receive either tirzepatide or a placebo for 12 months. The goal is to see if significant weight l…

This study tests whether adding a kidney nerve procedure (renal denervation) to the standard heart ablation can improve long-term control of persistent atrial fibrillation (AFib). About 50 adults with AFib and controlled or no high blood pressure will be randomly assigned to rece…

This study looks at the best time to start blood thinners after a stroke caused by a clot in the brain, in people who also have an irregular heartbeat (atrial fibrillation). All participants will have had emergency surgery to remove the clot. The goal is to see if starting blood …

This study tests a new device called the SpherePVI catheter to treat a common heart rhythm problem called atrial fibrillation (AFib). About 100 adults with AFib will receive a procedure that uses heat to isolate faulty electrical signals in the heart. The goal is to restore a nor…

This study is for people with atrial fibrillation (an irregular heartbeat) who are at high risk for stroke but cannot take blood thinners. The LambrE device is implanted to close off a small pouch in the heart where clots often form. Researchers will track 220 patients to see how…

This study looks at 70 people with heart failure, atrial fibrillation (an irregular heartbeat), and a special pacemaker (CRT) that isn't working as well as it should. Participants will be randomly assigned to one of two procedures: ablation of the faulty electrical signals in the…

This study tests whether closing a small heart pouch (left atrial appendage) with a device, along with taking blood thinners, can better prevent another stroke in people with atrial fibrillation who already had a stroke despite being on blood thinners. About 482 participants will…

This study compares two approaches to taking blood thinners after a procedure for atrial fibrillation (an irregular heartbeat). One group takes blood thinners every day as usual. The other group takes them only when a small heart monitor detects that the irregular rhythm has retu…

This study compares two catheter ablation methods for people with persistent atrial fibrillation (AFib). One method only isolates the pulmonary veins, while the other also targets scar tissue in the left atrium. The goal is to see which approach better prevents abnormal heart rhy…

This study looks at 300 adults with atrial fibrillation (an irregular heartbeat) who have had a brain bleed. It compares three approaches to prevent future strokes: taking blood thinners, using a device to close a part of the heart, or avoiding both. The goal is to find which opt…

This study compares a new pacing method called His bundle pacing to the standard right ventricular pacing in 100 adults with symptomatic atrial fibrillation and heart failure who are undergoing AV node ablation. The goal is to see if the new method improves walking distance, symp…

This study observes centers where one doctor schedules eight or more left atrial appendage occlusion (LAAO) procedures in a single day. It aims to see if this high-volume approach is safe and effective for patients with atrial fibrillation. About 678 adults receiving a Watchman d…

This study tests a new catheter called VARIPULSE against an already-approved one (FARAWAVE) for people with persistent atrial fibrillation, a condition where the heart beats irregularly for over a week. About 466 participants will receive one of the two treatments to see which is…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 participants will wear a heart monitor for two weeks at the start and again after three months of t…

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. About 50 adults with either short-lasting (paroxysmal) or longer-lasting (persistent) atrial fibrillat…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AF) in overweight or obese adults. About 200 people aged 18-75 with AF and a BMI of 30 or higher will receive semaglutide alongside standard AF care. The goal is to see …

This study tests a new device called FARAFLEX that uses pulsed field ablation to treat people with persistent or occasional atrial fibrillation (an irregular heartbeat). About 250 adults will receive either the new catheter or a standard one to see if it safely and effectively cr…

This study compares two types of ablation (pulsed field vs cryoballoon) for people with atrial fibrillation, a heart rhythm problem. About 104 participants will be randomly assigned to one of the two methods. The main goal is to see which technique creates better scar tissue arou…

This study combines two heart procedures into one session for people with atrial fibrillation (AFib). The first uses pulsed field energy to fix the irregular heartbeat, and the second closes a small pouch in the heart to lower stroke risk. About 433 adults who need both treatment…

This study tests a new device that uses quick electric pulses to fix faulty heart signals in people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 440 adults who have not gotten relief from medication will receive the procedure. The goal is to see…

This study looks at the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants will undergo a procedure to isolate the…

This study tests whether a smartwatch can find irregular heartbeats (atrial fibrillation) that often go unnoticed after heart surgery. About 324 adults who had heart surgery will either use a smartwatch or receive standard care. The goal is to see if the watch helps doctors catch…

This early-phase study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately find clots anywhere in the body, including in the heart of people with atrial fibrillation. The study in…

This study tests whether the heart medication amiodarone can prevent atrial fibrillation (an irregular, often rapid heartbeat) in people recovering from minimally invasive esophageal cancer surgery. Atrial fibrillation is the most common complication after this surgery, and there…

This study tests if placing amiodarone directly into the sac around the heart during bypass or valve surgery can prevent a common complication called atrial fibrillation. About 63 adults aged 20-85 will be monitored continuously after surgery. The goal is to reduce irregular hear…

This study tests a special device that seals the leg puncture after a heart procedure for atrial fibrillation. The goal is to see if it helps patients get up and walk sooner compared to standard manual pressure and stitches. About 100 adults having AF ablation will be randomly as…

This study tests a new device (TS-RF system) against a standard needle for a heart procedure called transseptal puncture, which helps doctors reach the left upper chamber of the heart. The goal is to treat conditions like atrial fibrillation (irregular heartbeat) and mitral steno…

This study looks at whether helping patients have realistic expectations before a catheter ablation for atrial fibrillation can improve their quality of life during the first three months after the procedure. About 60 adults with symptomatic atrial fibrillation will take part. Th…

This study tests if a personalized, app-based exercise program can reduce symptoms like heart fluttering and shortness of breath in people with atrial fibrillation (AFib). Researchers will enroll 120 adults with AFib who are already somewhat active. Participants will use a sensor…

This study looks at whether a heart procedure called ablation, combined with a 12-week exercise program, helps people with heart failure and atrial fibrillation use oxygen better. About 40 adults with both conditions will take part. The goal is to see if the combination improves …

This study tests if using a small ultrasound probe placed inside the heart (called ICE) works as well as the standard throat ultrasound for guiding the placement of a Watchman device. The Watchman is a small plug that helps prevent strokes in people with atrial fibrillation. Abou…

This study aims to find out if restoring a normal heart rhythm through a procedure called cardioversion truly improves quality of life for people with persistent atrial fibrillation (AF). One hundred adults with AF will be randomly assigned to receive either real cardioversion or…

This study tests a digital toolkit (smartphone app) designed to help people with atrial fibrillation (AFib) learn about their condition, stick to treatments, and handle AFib episodes with less anxiety. Researchers will measure if the tool improves quality of life and reduces AFib…

This study tests whether a defibrillator that delivers a 360-joule shock works better than one that delivers a 200-joule shock for restoring normal heart rhythm in people with atrial fibrillation. About 376 adults scheduled for elective cardioversion will take part. The goal is t…

This study compares two types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against standard care in 132 adults with persistent or permanent atrial fibrillation. The goal is to see which approach best improves exercise cap…

This study tests whether giving magnesium through an IV can safely lower a dangerously fast heart rate in people with atrial fibrillation or flutter. About 153 adults will receive either a low dose (2g), a higher dose (4g), or a placebo. The main goal is to see if magnesium helps…

This study aims to see if certain blood markers that indicate clotting risk go up when atrial fibrillation (an irregular heartbeat) gets worse. Researchers will take blood samples from 20 adults before, during, and after a standard heart procedure called catheter ablation. The go…

This study looks at whether sleep apnea can cause scarring in the heart's upper chambers, even before a heart rhythm problem develops. Researchers will use special MRI scans to measure scarring in 60 adults with different severities of sleep apnea, some with and some without atri…

This study looks at whether a connected watch can track heart rhythm better than usual check-ups in people who develop atrial fibrillation after heart surgery. About 106 adults will either use the watch or get standard care with ECGs at 3, 6, and 12 months. The goal is to see if …

This study is a registry that collects information on patients with atrial fibrillation (an irregular heartbeat) who are treated with a surgical procedure called cardiac ablation during heart surgery. The goal is to understand how this treatment is used in everyday medical practi…

This study is creating a large collection of blood samples from 1,000 people with atrial fibrillation (an irregular heartbeat) and stroke. Researchers will analyze the DNA and plasma to better understand the genetic causes linking these conditions. The goal is to find new targets…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky heart valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and risk factors that predict disease p…

This study is observing 1400 people who get a small heart monitor implanted under their skin. The monitor watches for irregular heartbeats like atrial fibrillation or slow heart rate. Researchers want to see how quickly the device finds these problems and how easy it is to insert…

This study looks at the heart signals of 200 people with atrial fibrillation (AF) to understand why some respond better to a procedure called ablation. Researchers will map organized electrical areas in the heart and see if larger areas predict success. The goal is to help doctor…

This study follows 24 adults who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers will track how AF changes over two years using heart monitors and blood tests. The goal is to better understand AF progression in stroke su…

This study looks at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called ablation. Researchers want to see if more scarring means a higher chance of AF coming back or needing hospital care. …

This study follows 1,125 adults who have had or will have a procedure called catheter ablation for atrial fibrillation (an irregular heartbeat). Over one year, participants use a smartphone app to answer surveys about their lifestyle, symptoms, and quality of life. The goal is to…

This study follows 2,000 people with atrial fibrillation who are taking long-term blood thinners. Researchers will track how many have heart problems like stroke or heart attack, and how many have bleeding events. The goal is to better understand the risks of these medications, n…

This study is for people with beta-thalassemia who need regular blood transfusions. Researchers want to compare those who have atrial fibrillation (a type of irregular heartbeat) with those who don't, to find differences in health tests and lab results. The goal is to learn more …

This study tracks 150 adults having planned open-heart surgery to see how often atrial fibrillation (AF) occurs afterward. Participants wear a small EKG patch to record heart rhythms, and researchers will look for patterns and risk factors. The goal is to better understand AF's t…

This study compares different computer methods to map the heart's electrical activity in people with atrial fibrillation (an irregular heartbeat). Researchers will analyze data from 1,000 adults aged 21-80 who are already scheduled for a heart procedure. The goal is to find which…

This study is for people with heart failure who do not have a pacemaker or defibrillator. Researchers will use a small implanted device called BIOMONITOR IV to track heart rhythms and other body signals over time. The goal is to learn how often irregular heartbeats happen and to …

This study is testing a new 3D imaging system called VERAFEYE that helps doctors guide catheter ablation procedures for people with atrial fibrillation or atrial flutter. About 50 adults scheduled for ablation will take part. The goal is to see how well the system works and gathe…

This study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems. The goal is to learn how often these problems hap…

This study looks at whether a week of exercise (moderate or high intensity) changes symptoms of atrial fibrillation compared to a week of rest. It includes 36 adults aged 40+ with paroxysmal or persistent AF who have had symptoms recently. The main goal is to see if a larger stud…

This study aims to find out if a simple ECG test can identify which patients with atrial fibrillation are at risk of forming blood clots that lead to stroke. Researchers will analyze heart tissue and blood samples from 1,000 adults undergoing open-heart surgery, along with their …

This study follows 750 adults who are getting a standard procedure (catheter ablation) for atrial fibrillation, a common heart rhythm problem. The main goal is to figure out why the condition comes back in up to 45% of people within a year. Researchers will track participants for…

This study watches 400 adults in the US who are getting a procedure for atrial fibrillation (a type of irregular heartbeat). Doctors use special AI software to help guide the procedure. The goal is to see how well the AI works in real-world hospitals by tracking heart rhythm prob…

This study aims to improve how we detect and understand heart disease using a new type of MRI that looks at the heart's microscopic structure. Researchers will compare these advanced scans with standard tests and blood work in 1,000 adults, both healthy volunteers and those with …

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…

This study is a global registry that will follow about 540 people with atrial fibrillation who receive a heart procedure using the Affera platform. The goal is to see how well the procedure stops abnormal heart rhythms and how safe it is in routine medical practice. Participants …

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. The study will enroll 50 adults and focus on how well the system w…

This study looks at whether a special heart ultrasound done before cardiovascular surgery can help predict which patients will develop atrial fibrillation (an irregular heartbeat) after their operation. Researchers will follow 138 adults who are in normal rhythm before surgery an…

This study aims to find new biomarkers in blood and saliva that can quickly and accurately tell if someone is having a stroke. Researchers will study 650 adults with suspected stroke to improve early detection and diagnosis. The goal is to develop better tools to differentiate st…

This study looks at 200 adults with early-onset atrial fibrillation (before age 60) who have certain genetic changes. Researchers will use cardiac MRI and electrical mapping during a scheduled heart procedure to see who is at risk for ventricular tachycardia, a dangerous fast hea…

This study is a large registry that will collect data from 10,000 people with atrial fibrillation who are scheduled for or have had a heart ablation procedure. The goal is to track how well the procedure controls the heart rhythm and to monitor any side effects. The study does no…

This study at Stanford University is testing whether a computer program can help doctors better treat atrial fibrillation, a common heart rhythm problem. About 120 adults with AF who are scheduled for a procedure called ablation will take part. The researchers will use machine le…

This study is looking at 50 adults without prior irregular heartbeat who are scheduled for heart surgery. Researchers want to see if scarring (fibrosis) in the heart's upper chambers before surgery can predict who will develop a temporary irregular heartbeat after the operation. …

To evaluate the progression of atrial myopathy through wearable devices and cardiac imaging.