ATRIAL FIBRILLATION

This study tests whether using a patient's gender, weight, and kidney function to calculate the first dose of the blood thinner heparin helps reach the target level faster than using a standard dose based only on weight. About 145 adults with conditions like deep vein thrombosis,…

This study tests whether the blood thinner edoxaban can reduce the risk of stroke or blood clots in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or no blood thinner (just aspi…

This study tests if a device called the Amulet, which closes a small pouch in the heart, is as safe and effective as daily blood thinner pills for preventing strokes in people with atrial fibrillation. About 2,650 participants will be randomly assigned to get the device or take s…

This study planned to test a device called LAmbre Plus that blocks a small pouch in the heart (the left atrial appendage) in people with an irregular heartbeat (atrial fibrillation) who are at high risk for stroke. The goal was to see if the device could safely prevent strokes be…

This study compares two ways of doing a heart procedure called catheter ablation for people with atrial fibrillation (a fast, irregular heartbeat). One group gets the standard treatment plus a drug to find missed spots, while the other gets extra ablation circles. The goal is to …

This study compares three different surgical ablation techniques (Cox-Maze IV, Tampa 2, and EnCompass alone) to treat atrial fibrillation, a common heart rhythm disorder. About 220 adults with a history of atrial fibrillation who are already scheduled for heart surgery will take …

This study follows 550 adults with atrial fibrillation who are getting a standard heart ablation procedure using the FARAPULSE system and a new mapping tool called FARAVIEW. The goal is to see how safe and effective the procedure is over one year, and to understand what factors a…

This study aimed to see if giving the drug amiodarone for a short time after heart surgery could prevent a common complication called atrial fibrillation (an irregular heartbeat). The trial planned to include adults having heart surgery other than bypass, who had a normal heart r…

This study tests a new device that uses electrical pulses to treat atrial fibrillation (AFib), a common heart rhythm problem. About 25 people with AFib will receive the procedure to see if it safely and effectively restores normal heart rhythm. The goal is to control the conditio…

This study tests three different catheter ablation techniques in 617 adults with persistent atrial fibrillation (AF) to see which best controls heart rhythm. Participants receive one of three procedures: isolating the pulmonary veins alone, adding ablation of abnormal electrical …

This study tests a new oral blood thinner called milvexian against the standard drug apixaban in about 20,000 adults with atrial fibrillation (an irregular heartbeat). The goal is to see if milvexian is at least as good as apixaban at preventing strokes and blood clots elsewhere …

This study is a real-world registry that will follow 10,000 people with atrial fibrillation who are getting a procedure called pulsed field ablation using the Farapulse system. The goal is to see how safe and effective the procedure is over the long term. Participants will be mon…

This study looks at two different treatments for older adults (75 and older) with a type of irregular heartbeat called persistent atrial fibrillation. One treatment uses a pacemaker plus a procedure to block the heart's electrical signal, while the other uses a procedure to isola…

This study tests whether liraglutide, a medication that reduces fat and promotes weight loss, can shrink the fat deposits around the heart and help stabilize atrial fibrillation (AF) in people who have had a catheter ablation. About 60 adults with AF and a BMI of 27 or higher wil…

This study tests a modified version of the Maze procedure, done at the same time as other heart surgery, to treat atrial fibrillation (an irregular heartbeat). The goal is to safely restore a normal rhythm and reduce stroke risk. About 151 adults with AFib scheduled for heart sur…

This study looks at two methods for treating atrial fibrillation (a common heart rhythm problem) using a special balloon catheter that delivers radiofrequency energy to isolate the veins in the heart. The goal is to see if using a 3D mapping system (CARTO) makes the procedure fas…

This study tests a computer alert that reminds doctors to prescribe blood thinners for patients with atrial fibrillation, a heart condition that raises stroke risk. About 5,000 patients and their doctors are taking part. The goal is to see if the alert helps more patients start a…

This study tests whether using a special risk score (ABC-score) to personalize treatment can lower the chance of stroke or death in people with atrial fibrillation, a common heart rhythm problem. About 3,900 participants were randomly assigned to either receive care guided by thi…

This study compares two catheter ablation methods for people with persistent atrial fibrillation (AF), a type of irregular heartbeat. About 500 participants will either receive standard treatment (isolating the pulmonary veins) or a tailored approach that also targets areas of lo…

This study tests whether people with atrial fibrillation can take just one blood thinner or aspirin instead of two drugs after getting a WATCHMAN FLX Pro device to close a heart pouch. The goal is to see if these simpler plans are as safe and effective at preventing stroke and ma…

This study looks at 82 people with heart failure and a type of irregular heartbeat called atrial fibrillation. All participants will have a procedure to control their heart rate and then get a pacemaker. The study compares a newer pacing method (conduction system pacing) with the…

This study tests if a device called WATCHMAN FLX, which closes a small pouch in the heart, is a good alternative to daily blood thinners for preventing strokes in people with a common heart rhythm problem called atrial fibrillation. About 3000 participants are involved. The goal …

This study tests two heart procedures in 200 people with persistent atrial fibrillation and scarred heart tissue. One group gets standard vein isolation; the other also gets ablation of scarred areas. The goal is to see which approach better prevents irregular heartbeats for a ye…

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation procedure. About 120 adults with AFib will receive the monitor and be followed for 15 months. The…

This study looks at whether a tailored exercise and education program, given both before and after a first-time atrial fibrillation (AF) ablation, can improve heart fitness and quality of life. About 107 adults scheduled for AF ablation will be randomly assigned to either the exe…

This study looks at how well the Amulet device works in everyday medical practice to prevent stroke in people with atrial fibrillation (an irregular heartbeat). Over 600 participants at 16 U.S. sites were followed for 2 years. Researchers tracked complications, device closure suc…

This study looks at whether closing a small sac in the heart (the left atrial appendage) during heart surgery can help prevent strokes in people with atrial fibrillation. About 1500 patients having planned heart surgery are taking part. The goal is to see if this simple procedure…

This study tests a device called CLAAS that is placed in the heart to close off a small pouch (the left atrial appendage) in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing lifelong blood thinners. The study involves 80 participants and u…

This study tests a new tablet called Refralon to see if it can prevent atrial fibrillation or flutter from returning after the heart's normal rhythm has been restored. About 175 adults with persistent AFib or flutter will take either a low or high dose of Refralon or a placebo da…

This study tests a new system that uses pulsed field ablation to treat atrial fibrillation, a common heart rhythm problem. About 300 people with symptoms that haven't improved with medication will receive the procedure. The goal is to see if it safely and effectively restores a n…

This study compares two blood thinners, dabigatran and warfarin, in 370 people with atrial fibrillation (irregular heartbeat) and moderate to severe mitral stenosis (narrowed heart valve). The goal is to see if dabigatran is as safe and effective as warfarin at preventing strokes…

This study follows over 1,100 people with atrial fibrillation who received a new treatment called FARAPULSE pulsed field ablation. The procedure uses electrical pulses to destroy tiny areas of heart tissue causing irregular rhythm. Researchers are watching for safety issues and h…

This study checks if a special blood pressure monitor (Withings BPM Core) can correctly detect atrial fibrillation, a common heart rhythm issue. Researchers compared the device's readings to a standard 12-lead ECG in 160 adults. The goal is to see if this easy-to-use home device …

This study checks how well the Withings Move ECG watch can detect atrial fibrillation, a common heart rhythm issue, compared to a standard 12-lead ECG. About 234 adults will wear the watch and also get a standard ECG to see if the watch's readings are accurate. The goal is to see…

This study tests whether a waterproof, wireless heart monitor worn for 7 days can find more cases of atrial fibrillation (an irregular heartbeat) in people who recently had a stroke or mini-stroke than the usual 24-hour Holter monitor. About 320 adults with no known cause for the…

This study tests whether wearable heart monitors can find hidden atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 337 participants will use either a short-term continuous patch or a long-term intermittent device to see which detects more cas…

This study tests whether an Apple Watch can catch early signs of atrial fibrillation (a common heart rhythm problem) in 2,000 people who are at high risk but haven't been diagnosed yet. Participants wear the watch for long-term monitoring. The goal is to see if this simple device…

This study tested whether a risk score based on health records can help find people with hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors used a remote ECG monitor at home. The g…

This study looks at whether the diabetes drug metformin, combined with lifestyle and risk factor changes, can reduce episodes of atrial fibrillation (a type of irregular heartbeat) in people with pacemakers or defibrillators. About 175 participants will be randomly assigned to re…

This study tests whether aggressively managing risk factors (like high blood pressure, obesity, and diabetes) and avoiding triggers (like alcohol and smoking) can prevent atrial fibrillation from returning after a heart procedure called ablation. About 509 adults with atrial fibr…

This study tests whether actively cooling the esophagus during a heart ablation procedure helps people with atrial fibrillation (an irregular heartbeat) have better results. About 312 adults with symptomatic AFib who are scheduled for ablation will be followed for up to 12 months…

This study tests a single 30-minute IV infusion of HBI 3000 in 150 adults aged 18 to 80 who have had atrial fibrillation for 2 to 72 hours. The goal is to see if the drug can safely and quickly convert the heart back to a normal rhythm. The trial first finds the best dose in an o…

This study tests whether adding online weight loss classes to standard cardiac rehab helps people with atrial fibrillation (AFib) and obesity lose at least 10% of their body weight and feel better. About 120 adults with AFib and a BMI of 30 or higher will take part. The goal is t…

This study compares a standard heart procedure called pulmonary vein isolation (PVI) to a fake (sham) procedure to see if the symptom relief in atrial fibrillation patients is real or just a placebo effect. About 262 adults with symptomatic atrial fibrillation will be randomly as…

This study looks at whether sending cardiologists quarterly emails about their prescribing habits can help more patients get the right medications for heart failure and atrial fibrillation. About 7,000 patients will be included. The goal is to see if this simple feedback strategy…

This study aimed to confirm whether certain blood markers (like NT-proBNP and IL-6) are linked to the severity of atrial fibrillation, a common heart rhythm problem. Researchers planned to analyze samples from 266 patients before and after treatment to see if these markers could …

This study looks at whether people with atrial fibrillation (an irregular heart rhythm) experience temporary changes in thinking, memory, or focus during an episode. About 600 participants will take tablet-based cognitive tests while in atrial fibrillation and again when their he…

This study tests whether a new type of ECG (called wavECG) can better predict who will develop atrial fibrillation after open-heart surgery. Researchers will follow 353 adults having their first open-heart surgery, using wavECG, standard ECG, and echocardiograms. The goal is to i…

This study looks at whether insulin resistance (when the body doesn't respond well to insulin) can predict how well a heart procedure called pulsed field ablation works for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their firs…

This study follows 5,000 adults with persistent atrial fibrillation (a heart rhythm problem) in Southwest China for 5 years. Researchers will collect information on treatments, side effects, and health outcomes to learn what works best. The goal is to improve personalized care an…

This study aims to classify patients with atrial fibrillation based on the electrical patterns in their hearts using computer simulations, rather than just how long they've had the condition. Researchers will study 91 people already scheduled for a heart procedure to see if this …

This study follows 186 people with atrial fibrillation (an irregular heartbeat) who are having a catheter ablation procedure. Doctors will use an AI software to help identify and treat the abnormal heart signals. The goal is to see how well the AI-guided approach works in everyda…

This study looks at past medical records from France to see how doctors prescribe blood thinners to people with atrial fibrillation (an irregular heartbeat) who also have a high risk of stomach bleeding. It aims to understand which treatments are used and how often serious bleedi…

This study is a registry that collects medical information and blood samples from over 2,400 people who are scheduled for a procedure called atrial fibrillation (AF) ablation. The goal is to find out which factors—like genetics or blood markers—can predict whether the procedure w…

This study looks at whether a small device placed under the skin (an implantable cardiac monitor) can find hidden atrial fibrillation in people with heart failure who are at high risk for stroke. About 477 participants will either get the monitor or standard care. The goal is to …

This study tests whether watching storytelling videos can help African American patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners, which lower stroke risk. About 80 participants will be randomly assigned to view the videos or rece…

This study aims to uncover the genetic factors that contribute to atrial fibrillation, a common heart rhythm disorder. Researchers will collect blood samples and health data from 1300 adults—some with the condition and some without—to build a gene bank. The goal is to better unde…

This study looks at 1400 women who had a stroke with no known cause. It tests if using a small heart monitor for a long time can find hidden heart rhythm problems and help doctors choose blood thinners to prevent another stroke. The goal is to see if this approach reduces disabil…

This study aimed to compare a new, more targeted ablation method with the standard approach for treating atrial fibrillation (an irregular heartbeat). Researchers planned to enroll people with symptomatic paroxysmal AF to see if the new technique could shorten procedure time and …

This study aims to detect hidden episodes of atrial fibrillation (an irregular heartbeat) in 1,200 acutely ill patients aged 50 and older who are at risk. Participants will be monitored with devices to catch brief heart rhythm changes that could lead to stroke. The goal is to use…

This study watches 50 adults with chronic lymphocytic leukemia who are starting certain drugs (acalabrutinib or zanabrutinib). These drugs can cause high blood pressure and irregular heartbeats. Participants will use wearable devices at home to track their heart rhythm and blood …