ATRIAL FIBRILLATION

This large VA study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in 10,000 veterans with atrial fibrillation. The goal is to determine which medication is safer (causes less major bleeding) and at least as effective at preventing stro…

This study is testing how well a new pulsed-field ablation system works for treating persistent atrial fibrillation, a type of irregular heartbeat that lasts over a week. Researchers will enroll 50 participants to measure procedure times, how effectively the treatment isolates pr…

This study tests whether a telemedicine support program helps village doctors better manage older adults with both atrial fibrillation and heart failure in rural China. About 1,200 participants will receive either the digital program with medication guidance, remote expert suppor…

This study is testing whether a nasal spray called etripamil can safely and quickly lower a dangerously fast heart rate during episodes of atrial fibrillation (AFib). About 750 adults with a history of symptomatic AFib will be given either the real spray or a placebo to use at ho…

This study is testing a new procedure called pulsed field ablation for people with a common heart rhythm problem (atrial fibrillation) who have already had a small heart pouch closed to prevent strokes. The goal is to see if this new technique is safe and effective at stopping th…

This pilot study is testing a small heart implant, called a left atrial appendage occlusion (LAAO), in patients who have both kidney failure requiring dialysis and atrial fibrillation (AF). The goal is to see if this device is a safe and effective way to prevent strokes and major…

This study aims to find the best medication plan to prevent a second stroke in people who have just had a stroke, also have an irregular heartbeat (atrial fibrillation), and hardened brain arteries. Researchers will randomly assign about 586 participants to take either one standa…

This study is testing whether adding a special pacing technique and a minor ablation procedure to a standard heart defibrillator implant can improve outcomes for people with very severe heart failure and a permanent irregular heartbeat (atrial fibrillation). The participants are …

This study aims to find the best way to treat atrial fibrillation (an irregular heartbeat) in people who also have a specific type of heart failure. It will compare a minimally invasive procedure called catheter ablation against standard medication. About 900 participants will be…

This study is testing if weight loss surgery is better than medication and lifestyle changes at controlling atrial fibrillation (AFib) in people who are obese. It will enroll 100 adults with AFib and significant obesity. Researchers will compare how much AFib burden and symptoms …

This study is testing a procedure to implant a small device in the heart to help prevent strokes in people with atrial fibrillation. It specifically looks at using lighter 'conscious' sedation instead of full general anesthesia during the implant. Researchers want to see if this …

This study compares different standard methods for treating irregular heart rhythm (atrial fibrillation) using a procedure called pulmonary vein isolation. Over 1,100 patients at two Copenhagen hospitals will receive one of the standard treatments during their scheduled procedure…

This study aims to find out if a more extensive heart ablation procedure works better than the standard one for people with persistent atrial fibrillation (AFib). It will involve 406 adults whose AFib hasn't responded well to medication and who are getting their first ablation. R…

This study is testing whether a new artificial intelligence (AI) tool can help doctors find atrial fibrillation (AFib) sooner in people who have symptoms but haven't been diagnosed yet. About 1,230 adults in Korea will be randomly assigned to receive either standard heart monitor…

This study is testing a small, wireless heart monitor patch for patients in the hospital. The goal is to see if this new system can detect dangerous heart rhythms faster and more reliably than standard monitoring, helping doctors make quicker treatment decisions. It will involve …

This study aims to see if a new type of heart scan called magnetocardiography (MCG) is better than the standard ECG at predicting which patients with a specific heart rhythm condition (Long QT syndrome) can safely take the medication dofetilide. Researchers will enroll 100 adults…

This study aims to see if artificial intelligence (AI) can predict dangerous heart rhythm problems in patients before and after major, high-risk surgeries. Researchers will use a simple, portable heart monitor and a standard ECG to gather data from 300 patients. The AI will analy…

This study tests whether a telemedicine-supported care program can prevent heart failure in older adults with atrial fibrillation who live in rural China. 1,268 participants will be assigned by their local village clinic to receive either standard care or a digital program that i…

This study tests if a computer alert system can help doctors in community clinics prescribe blood-thinning medication to prevent strokes in high-risk patients with atrial fibrillation (AF). It will involve about 2,500 patients who are not currently on these medications. The goal …

This study tests whether connecting vulnerable atrial fibrillation patients with trained peer mentors for 16 weeks can reduce their anxiety and improve mental well-being. Researchers will compare 290 patients who receive peer support plus usual care against those receiving usual …

This study is testing a new decision support tool designed to help patients with atrial fibrillation understand their options for stroke prevention medication. The research team wants to see if this tool improves the quality of decisions and increases the use of recommended blood…

This study is observing 500 patients who receive a dual-chamber pacemaker to understand how different pacemaker settings affect the progression of atrial fibrillation (AF), a common heart rhythm disorder. Researchers will track patients over time to see if certain pacemaker featu…

This study aims to collect heart rhythm recordings from 600 people with various heart conditions using a portable ECG device. Participants will have their heart activity recorded during their normal medical care. The data will be compiled into an anonymous database to help resear…

This study aims to understand why some patients with heart rhythm problems respond well to treatments like pacemakers or ablation, while others do not. Researchers will observe 253 adults with various heart conditions who are scheduled for these procedures. By using advanced hear…

This study aims to find out how often a new, non-heat-based procedure for treating atrial fibrillation causes temporary paralysis of the main breathing muscle (the diaphragm). Researchers will enroll 250 patients and use special moving X-rays before and after the procedure to car…

This study aims to collect real-world information on how well a new 3D imaging system, called VERAFEYE, works during standard heart procedures. It will enroll 50 adults who are already scheduled for a procedure to treat an irregular heartbeat (atrial fibrillation) or to close off…

This study aims to test and validate new, faster heart MRI scanning techniques that can detect very early tissue damage. Researchers will compare these detailed heart images with standard blood tests in 1,000 participants, including both people with various heart conditions and h…

This study is testing a new software tool designed to help doctors better measure the success of a heart procedure called pulsed field ablation (PFA), which treats atrial fibrillation. It will observe 100 patients undergoing the standard procedure to see if the software's measure…

This study aims to learn from real-world experience with a newer heart procedure called pulsed field ablation (PFA) for atrial fibrillation (AFib). It will follow 1,100 patients in Spain for one year after their standard-care PFA procedure. The main goal is to identify up to ten …