ATRIAL FIBRILLATION

This study tests a new way to treat atrial fibrillation (an irregular heartbeat) in people who already have a device to prevent strokes. The procedure uses short electrical pulses to fix the heart's electrical signals. About 70 adults will be followed for one year to see if the t…

This study compares a new dual electrical shock technique to the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation (an irregular heartbeat). About 177 adults will be randomly assigned to receive either the dual shock or the conv…

This study tests a new device called the VARIPULSE catheter system for people with persistent atrial fibrillation (a type of irregular heartbeat that lasts more than a week). The procedure uses heat energy to isolate certain veins in the heart to restore normal rhythm. About 920 …

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or a heart pump. Participants will receive a special pacemaker and a procedure to calm the heart's electrical signals, along with an im…

This study compares different standard methods for a heart procedure called ablation, used to treat atrial fibrillation (an irregular heartbeat). About 1,125 adults will take part, and each will receive the method that is standard at the time of their treatment. The goal is to se…

This study looks at 900 adults with atrial fibrillation (an irregular heartbeat) and a type of heart failure where the heart's pumping ability is mildly reduced or preserved. It compares a procedure called catheter ablation (which destroys tiny areas of heart tissue causing the i…

This study tests a special catheter to treat paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). About 300 adults aged 18-80 who have symptoms despite medication will receive the procedure under different sedation types. The goal is to see how well…

This study tests a device called CLAAS that is implanted to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation. The goal is to reduce stroke risk and allow patients to stop taking long-term blood thinners. About 300 adults with AF …

This study compares two approaches for treating persistent atrial fibrillation (AFib), a common heart rhythm problem. About 406 adults having their first catheter ablation will either receive standard pulmonary vein isolation (PVI) alone or PVI plus ablation of extra triggers fou…

This study tests if metabolic (weight-loss) surgery can reduce the severity of atrial fibrillation (AF), a common heart rhythm disorder, in people with obesity. About 100 adults with AF and a BMI of 35-65 will be randomly assigned to surgery or standard care. The main goal is to …

This study tests a new pulsed field ablation system (VARIPULSE catheter and TRUPULSE generator) with updated software in 50 adults with persistent atrial fibrillation (an irregular heart rhythm lasting over 7 days). The goal is to see how well the system works during the procedur…

This study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in about 10,000 veterans with atrial fibrillation (an irregular heartbeat). The goal is to see which drug better prevents strokes, major bleeding, and death. Participants must al…

This study tests a procedure called left atrial appendage occlusion (LAAO) in 40 dialysis patients with atrial fibrillation to prevent strokes. The goal is to see if it is safe and effective, allowing patients to avoid long-term blood thinners that raise bleeding risks. Participa…

This study tests a telemedicine program for older adults (ages 65-80) with both atrial fibrillation and heart failure in rural China. Village doctors use a digital platform with remote expert support to guide medication and lifestyle changes, including group exercise and wearable…

This study tests whether an artificial intelligence tool (SmartECG-AFrisk) can detect atrial fibrillation (AF) earlier than standard care in 1,230 adults with symptoms like palpitations or dizziness but no prior AF diagnosis. Participants are randomly assigned to usual monitoring…

This study will test a small, single-lead ECG patch that sticks to the chest and sends heart rhythm data to a central monitoring system. It aims to help doctors spot serious heart rhythm problems like atrial fibrillation or ventricular tachycardia faster in hospitalized patients.…

This study tests if a numbing injection near certain neck nerves, given before heart bypass surgery, can prevent a common complication called atrial fibrillation (an irregular heartbeat). About 450 adults having bypass surgery will receive either the nerve block or a placebo. The…

This study tests whether giving the sedative dexmedetomidine during and after mitral valve surgery can lower the chance of developing a new, fast, and irregular heartbeat called atrial fibrillation. About 140 adults having this surgery will be randomly assigned to receive the dru…

This study compares apixaban alone versus apixaban plus clopidogrel in 586 adults who recently had a stroke due to atrial fibrillation and hardened brain arteries. Participants take either one or two blood thinners for 30 days. The goal is to see if the combination better prevent…

This study tests whether a telemedicine program led by village doctors can prevent heart failure in older adults (ages 65-80) in rural China who have atrial fibrillation but not yet heart failure. Participants will either receive standard care or a digital program with wearable h…

This study tests whether two heart medications, amiodarone and metoprolol, can prevent new atrial fibrillation (an irregular heartbeat) in people who have just had a valve replacement procedure called TAVR. About 198 participants who show early signs of extra heartbeats after TAV…

This study tests whether electronic alerts in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goal …

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can help reduce anxiety in vulnerable patients. About 290 adults with AFib and lower education levels will either receive usual care or be matched with a mentor for 16 weeks. The goal i…

This study tests an experimental nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. Participants will use the spray at home when symptoms start, with an optional second dose if needed. The goal is to see…

This study tests a new way to treat a common heart rhythm problem called atrial fibrillation (AFib). The method uses pulsed field ablation, which targets only heart cells and may be safer for nearby tissues. Doctors will also use a special 3D ultrasound system to map the heart wi…

This study tests whether using a brain-activity monitor (BIS) to guide sedation during electrical cardioversion for atrial fibrillation leads to faster recovery and fewer side effects compared to standard clinical checks. Sixty adults will be randomly assigned to either BIS-guide…

This study is testing a new software tool that helps doctors see, during a heart procedure, whether they have successfully treated the tissue causing atrial fibrillation. About 100 adults having their first such procedure will take part. The goal is to see if the software can acc…

This study will collect information from 50 adults having standard heart procedures for atrial fibrillation or left atrial appendage closure using the VERAFEYE imaging system. The goal is to see how well the system helps doctors create 3D heart models and complete the procedures …

This study tests whether an artificial intelligence (AI) system can help doctors find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 400 participants will be split into two groups: one gets AI-guided monitoring with wearable devices and…

This study will collect heart recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The recordings will be used to create a database for future research and regulatory submissions. No treatment or diagnosis is given—the data is for observation only.

This study will follow 1100 people who have already had a heart ablation for atrial fibrillation using pulsed field ablation and now need a repeat procedure. Researchers want to find out which patient traits or procedure details predict the need for a second ablation. The goal is…

This study looks at how often a new heart procedure called pulsed field ablation (PFA) for atrial fibrillation causes temporary diaphragm paralysis. About 250 adults having their first PFA will get a special X-ray before and after the procedure to check diaphragm movement. The go…

This study aims to see if artificial intelligence can predict serious heart rhythm problems in people having high-risk surgeries, such as heart, lung, or liver operations. Researchers will use a portable ECG device to record heart signals before surgery and analyze over 200 diffe…

This study follows 500 people with dual-chamber pacemakers to see if certain pacemaker settings increase the risk of developing permanent atrial fibrillation (an irregular heartbeat). Participants will have their devices checked regularly and report quality of life over time. No …

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and remote monitoring to see which patients respond best to treatment and which have complications. The goal is to fin…

This study compares a new heart test called magnetocardiography (MCG) to the standard ECG in 100 adults with Long QT syndrome and atrial fibrillation. The goal is to see if MCG can more accurately predict who will have complications during treatment with a heart medication. Parti…

This pilot study tests whether a patient decision support tool can help Black and White adults with atrial fibrillation make better-informed choices about blood thinners to prevent strokes. The study enrolls 40 participants and measures how acceptable and useful the tool is, as w…

This study aims to test new MRI methods that can see tiny changes in heart muscle structure, which may help detect heart disease earlier than current tests. Researchers at the Cleveland Clinic will compare these advanced scans with standard blood tests and imaging in 1000 adults …