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Electric pulses aim to tame irregular heartbeat after stroke prevention surgery

NCT ID NCT07313228

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a procedure called pulsed field ablation in 70 people with atrial fibrillation who have already had a left atrial appendage occlusion to prevent stroke. The procedure uses electric pulses to destroy small areas of heart tissue causing the irregular rhythm. Researchers will check if it safely prevents atrial fibrillation from coming back over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pulsed field ablation (a procedure using electric pulses to destroy heart tissue causing abnormal rhythms)
What this could lead to
If successful, this could offer a safer way to control atrial fibrillation in patients who already had a stroke-prevention procedure, potentially reducing the need for long-term medication.
What could go wrong
This is a small, early-stage trial at one center with no comparison group. The procedure carries risks like bleeding, heart damage, or arrhythmia recurrence. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The selected population consists of adult patients with a documented history of atrial fibrillation who have undergone left atrial appendage occlusion and are planned to undergo pulsed field ablation due to ineffective drug treatment. Additionally, they must not have any surgical contraindications.

Ages

18 to 75 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18-75 years; 2. Documented symptomatic atrial fibrillation; 3. Ineffective or intolerant to at least one class I or III antiarrhythmic drug; 4. Able to fully understand the treatment protocol, voluntarily sign the informed consent form, and willing to undergo the required examinations, procedures, and follow-up. Exclusion Criteria: 1. Patients who have previously undergone left atrial surgery; 2. Left atrial thrombus; 3. Patients with pulmonary agenesis; 4. Female patients of reproductive age who cannot use effective contraception within 12 months after enrollment; 5. Left atrial anteroposterior diameter ≥ 55 mm; 6. Left ventricular ejection fraction (LVEF) ≤ 40%; 7. Patients who have previously undergone interatrial septal repair or removal of atrial myxoma; 8. Patients with active implanted devices (e.g., pacemaker, ICD); 9. Patients with NYHA heart failure class III-IV; 10. Patients with a clear history of cerebrovascular disease (including cerebral hemorrhage, stroke, or TIA) within the past 6 months; 11. Patients who have experienced cardiovascular events (e.g., acute myocardial infarction, coronary intervention or bypass surgery, valve replacement or repair, atrial or ventricular surgery) within the past 3 months; 12. Patients with acute or severe systemic infections; 13. Patients with severe liver or kidney disease, malignancy, or end-stage disease that may affect the treatment, assessment, or compliance of the trial (as judged by the investigator); 14. Patients with significant bleeding tendency, hypercoagulable state, or severe hematologic disorders; 15. Patients who have participated or are currently participating in another clinical trial within the past 12 months prior to enrollment; 16. Patients who the investigator deems unsuitable for participation in this trial.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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