Electric pulses aim to tame irregular heartbeat after stroke prevention surgery
NCT ID NCT07313228
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a procedure called pulsed field ablation in 70 people with atrial fibrillation who have already had a left atrial appendage occlusion to prevent stroke. The procedure uses electric pulses to destroy small areas of heart tissue causing the irregular rhythm. Researchers will check if it safely prevents atrial fibrillation from coming back over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pulsed field ablation (a procedure using electric pulses to destroy heart tissue causing abnormal rhythms)
- What this could lead to
- If successful, this could offer a safer way to control atrial fibrillation in patients who already had a stroke-prevention procedure, potentially reducing the need for long-term medication.
- What could go wrong
- This is a small, early-stage trial at one center with no comparison group. The procedure carries risks like bleeding, heart damage, or arrhythmia recurrence. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The selected population consists of adult patients with a documented history of atrial fibrillation who have undergone left atrial appendage occlusion and are planned to undergo pulsed field ablation due to ineffective drug treatment. Additionally, they must not have any surgical contraindications.
- Ages
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18 to 75 years
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged 18-75 years; 2. Documented symptomatic atrial fibrillation; 3. Ineffective or intolerant to at least one class I or III antiarrhythmic drug; 4. Able to fully understand the treatment protocol, voluntarily sign the informed consent form, and willing to undergo the required examinations, procedures, and follow-up. Exclusion Criteria: 1. Patients who have previously undergone left atrial surgery; 2. Left atrial thrombus; 3. Patients with pulmonary agenesis; 4. Female patients of reproductive age who cannot use effective contraception within 12 months after enrollment; 5. Left atrial anteroposterior diameter ≥ 55 mm; 6. Left ventricular ejection fraction (LVEF) ≤ 40%; 7. Patients who have previously undergone interatrial septal repair or removal of atrial myxoma; 8. Patients with active implanted devices (e.g., pacemaker, ICD); 9. Patients with NYHA heart failure class III-IV; 10. Patients with a clear history of cerebrovascular disease (including cerebral hemorrhage, stroke, or TIA) within the past 6 months; 11. Patients who have experienced cardiovascular events (e.g., acute myocardial infarction, coronary intervention or bypass surgery, valve replacement or repair, atrial or ventricular surgery) within the past 3 months; 12. Patients with acute or severe systemic infections; 13. Patients with severe liver or kidney disease, malignancy, or end-stage disease that may affect the treatment, assessment, or compliance of the trial (as judged by the investigator); 14. Patients with significant bleeding tendency, hypercoagulable state, or severe hematologic disorders; 15. Patients who have participated or are currently participating in another clinical trial within the past 12 months prior to enrollment; 16. Patients who the investigator deems unsuitable for participation in this trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can exercise tame atrial fibrillation? trial tests workouts on heart rhythm and fitness
- Pacemaker lead position may cut heart rhythm complication
- Can zapping the heart beat drugs for AF in heart failure?
- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
- Two ways to quiet a racing heart: trial pits hybrid ablation against standard catheter treatment
- Stroke's hidden heart rhythm clue under investigation