ATRIAL FIBRILLATION

This registry study is collecting real-world safety and effectiveness data on a pulsed field ablation system used to treat atrial fibrillation. It will follow 500 patients for one year after their procedure to track outcomes and complications. The study aims to understand how dif…

This study is testing whether a new telemedicine support program can help vulnerable patients with heart failure stay healthier at home and avoid repeat hospital visits. The program connects patients, their home caregivers, and their family doctors with hospital heart specialists…

This study is testing a new medical device called the FARAFLEX system for people with a persistent irregular heartbeat called atrial fibrillation. The device uses electrical pulses to create small scars in the heart to block the faulty signals causing the problem. Researchers wan…

This study is testing a new digital app called VIRTUES, designed to help people manage various heart conditions from home. It will enroll 2000 participants across Canada to try seven core modules that give personalized advice on things like blood pressure, cholesterol, and heart …

This study is testing if a diabetes medication called Dapagliflozin can reduce the amount of time people with both diabetes and a type of irregular heartbeat (atrial fibrillation) spend in that dangerous rhythm. About 28 participants will be randomly assigned to take either the d…

This study is testing a new surgical tool designed to treat atrial fibrillation (an irregular heartbeat) while a patient is already undergoing planned heart surgery, like a valve repair or bypass. The device uses electrical pulses to create scar tissue in the heart to block the f…

This study is comparing two ways to manage heart failure in people who also have a permanent, irregular heart rhythm called atrial fibrillation. One group will get a pacemaker and a minor heart procedure to regulate their heartbeat, while the other group will receive standard med…

This study is testing whether a new oral medication called PKN605 can safely reduce the amount of time people spend in atrial fibrillation (AF), a common irregular heart rhythm. About 165 adults with a history of AF will be randomly assigned to take either PKN605 or a placebo pil…

This study is collecting real-world safety and effectiveness data on a balloon-based heart procedure (the Volt PFA System) used to treat symptomatic atrial fibrillation (AFib). It will enroll 300 adults with AFib who plan to undergo this specific ablation procedure. The main goal…

This study is observing a combined heart procedure that treats two problems at once: irregular heartbeat (atrial fibrillation) and stroke risk. Doctors will perform both a heart rhythm treatment and a stroke prevention device placement during the same procedure. The study aims to…

This study is collecting real-world data on a heart implant device called LambrE. The device is for patients with atrial fibrillation (AFib) who are at high risk of stroke but have a permanent medical reason they cannot take standard blood-thinning medications. The goal is to see…

This study directly compares two newer blood thinners (rivaroxaban and apixaban) to see which causes fewer bleeding problems in people with atrial fibrillation. Researchers will follow 3,018 patients for one year, tracking bleeding events while both medications work equally well …

This study is testing a new medical device system designed to treat a common type of irregular heartbeat called atrial fibrillation (AFib). The procedure uses pulsed electrical fields to scar heart tissue and block faulty electrical signals. Researchers aim to see if this new sys…

This study is testing whether combining a heart procedure (ablation) with a supervised exercise program works better than the procedure alone for people with a specific type of heart failure and a recent irregular heartbeat. Researchers will measure if this combination improves h…

This study compares two different guidance methods for a heart procedure that treats atrial fibrillation, an irregular heartbeat. Researchers want to see if using a simpler X-ray-only approach works as well as adding more detailed 3D mapping technology. Participants will have the…

This study aims to find the safest and most effective medication to prevent future strokes in people who have survived a brain bleed (intracerebral hemorrhage) and also have an irregular heart rhythm called atrial fibrillation. Researchers will compare a newer blood thinner (apix…

This study is testing the safety and initial performance of a new surgical device called the CellFX Cardiac Clamp. It is designed to treat atrial fibrillation (a type of irregular heartbeat) in patients who are already scheduled for other heart surgeries, like valve repair or byp…

This study is testing if a weekly weight-loss medication called Tirzepatide can help people with obesity and a heart rhythm disorder called atrial fibrillation. About 100 participants will receive either Tirzepatide or a placebo for 12 months to see if losing weight leads to bett…

This study aims to find the best dose of intravenous magnesium to quickly lower a dangerously fast heart rate caused by atrial fibrillation or flutter. Researchers will compare a 2-gram dose, a 4-gram dose, and a placebo (saltwater) in 153 adult patients who are already receiving…

This study is testing a new heart implant device called CLAAS that aims to prevent strokes in people with atrial fibrillation. The device seals off a small pouch in the heart where blood clots often form, offering an alternative to long-term blood thinner medications. Researchers…

This large study is testing if a smartwatch can safely guide when people with atrial fibrillation (AFib) need to take blood thinners. Instead of taking the medication every day, participants in the test group will only take it for one month after the watch detects an AFib episode…

This study is checking how well a heart procedure works over five years to prevent strokes in people with atrial fibrillation (AFib) who cannot take long-term blood thinners. Doctors close off a small pouch in the heart where clots often form. The research will follow 250 patient…

This study aims to find the safest time to start blood-thinning medication for stroke patients who have an irregular heartbeat (atrial fibrillation) and develop a specific type of brain bleed after a clot-removal procedure. It will compare starting the medication early versus lat…

This study compares two approaches for people with heart failure and chronic irregular heartbeat (atrial fibrillation). One group will receive optimized medication to control heart rate, while the other will undergo a procedure to implant a special pacemaker and disable a small p…

This registry aims to collect real-world safety and effectiveness data on heart ablation procedures for atrial fibrillation. It will follow up to 10,000 patients at medical centers worldwide for up to 10 years after their procedure. The study tracks how well the ablation controls…

This study is testing whether a newer, two-part 'hybrid' heart procedure works better than the standard catheter procedure for people who have both a long-lasting irregular heartbeat (persistent atrial fibrillation) and heart failure. About 120 participants will be randomly assig…

This study is observing how well patients do after a procedure for atrial fibrillation when doctors use special AI software as a guide. It will follow 400 U.S. patients who have had or will have this heart procedure. The main goal is to see how many patients remain free of signif…

This study is testing if ondansetron, a drug commonly used to prevent nausea, can help control atrial fibrillation (Afib), a dangerous irregular heartbeat. Researchers will give 80 people scheduled for a heart procedure either ondansetron or a placebo pill for 28 days to see if i…

This study compares two different defibrillator brands to see which one is more effective at restoring normal heart rhythm in people with atrial fibrillation. Researchers will test whether a device delivering higher maximum energy (360J) works better than one with lower maximum e…

This study is testing if a medication called semaglutide, which is approved for weight loss, can help people with both obesity and atrial fibrillation (AFib). Researchers want to see if losing weight with this drug can reduce how often AFib occurs and its severity when used along…

This study aims to find the best and safest time to restart blood-thinning medication for stroke patients who also have an irregular heartbeat called atrial fibrillation. Researchers will compare starting the medication early versus delaying it after patients have a procedure to …

This study is testing if adding a kidney nerve treatment to the standard heart ablation procedure helps people with a persistent form of atrial fibrillation (AFib) stay in normal rhythm longer. It will compare the combined procedure to the standard ablation alone in 50 participan…

This study is checking the long-term safety and effectiveness of an FDA-approved catheter system for treating irregular heartbeats. It involves 276 people with symptomatic atrial fibrillation who haven't responded well to medication. The research focuses on whether the treatment …

This study is testing a new medical device called the SpherePVI™ catheter system for treating paroxysmal atrial fibrillation, a type of irregular heartbeat. The trial will enroll 100 participants who haven't responded well to medication to see if the device can safely and effecti…

This study is testing a new medical device called the SpherePVI™ Multi-Ablation System to treat paroxysmal atrial fibrillation, a type of irregular heartbeat. The device uses a catheter to deliver targeted energy to isolate problematic veins in the heart that cause the irregular …

This study is tracking patients for three years after they receive a specific heart procedure called the PulseSelect PFA System to treat atrial fibrillation. The goal is to see how many patients stay free from irregular heart rhythms and to monitor for any safety issues related t…

This study is testing if a different type of heart ultrasound, done from inside the heart, can safely guide the placement of a device that helps prevent strokes in people with a common heart rhythm problem. The goal is to see if this new method works as well as the current standa…

This study is testing if a newer way to pace the heart (His bundle pacing) is better and safer than the standard method (right ventricular pacing) for people with a fast, irregular heartbeat (atrial fibrillation) who also have signs of heart failure. About 100 participants will b…

This study aims to find out which of two heart procedures works better for people who have both heart failure and atrial fibrillation (an irregular heartbeat). Seventy participants will be randomly assigned to receive either a procedure to restore normal heart rhythm or one to co…

This study aims to find out if adding a blood-thinning pill helps prevent strokes and other blood clots in patients who develop a temporary irregular heartbeat after coronary artery bypass surgery. It will compare the benefits of preventing clots against the risk of serious bleed…

This study is testing a new medical device that uses pulsed electrical fields to treat atrial fibrillation, a common type of irregular heartbeat. The device creates a detailed map of the heart's left atrium and then delivers targeted energy to disrupt the abnormal electrical sign…

This study is testing whether a catheter-based heart procedure that closes off a small pouch in the heart (left atrial appendage) can prevent strokes in people with atrial fibrillation. Participants have a high stroke risk despite already taking blood-thinning medications. The tr…

This study is testing a new care program to see if finding and treating a common sleep disorder (obstructive sleep apnea) can help control atrial fibrillation (AFib), a type of irregular heartbeat. About 209 adults with symptomatic AFib will use a simple home sleep test. If sleep…

This large international study is testing whether performing a heart rhythm procedure (ablation) soon after diagnosis can prevent strokes, heart failure, and cardiovascular death in people with atrial fibrillation who have other health conditions like high blood pressure or diabe…

This study is collecting real-world information on how well a new heart procedure device works and how safe it is for people with atrial fibrillation (an irregular heartbeat). It will follow about 1,950 patients who receive the PulseSelect PFA treatment in hospitals around the wo…

This study is for people with atrial fibrillation (AFib) who have had a stroke despite taking blood thinners. It tests if adding a heart procedure to close a small pouch in the heart (called the left atrial appendage) is better than just continuing blood thinners alone. The goal …

This study is testing a new pulsed field ablation system to treat people with symptomatic paroxysmal atrial fibrillation, a type of irregular heartbeat. The procedure aims to isolate problematic heart veins to prevent abnormal rhythms. Researchers will enroll 440 participants to …

This study compares two different pacemaker placement methods for people with atrial fibrillation who need a procedure to control their heart rhythm. Researchers want to see if placing pacemaker wires in a specific area of the heart's electrical system helps maintain better heart…

This study is collecting real-world data on how well the Affera cardiac ablation system works for treating atrial fibrillation (irregular heartbeat). Researchers will follow 540 patients worldwide who receive this already-approved treatment to track how many stay free from irregu…

This study is testing a new imaging and navigation system called VERAFEYE to see if it helps doctors better see inside the heart during standard procedures to treat irregular heartbeats (atrial fibrillation and flutter). The goal is to collect data on how well the system works an…

This study is testing if a smartwatch can find a dangerous irregular heartbeat that often happens silently after heart surgery. About 324 patients who just had heart surgery will be randomly assigned to either use a smartwatch for monitoring or receive the hospital's usual care. …

This early-stage study is testing a new imaging tracer called 64Cu-FBP8 to see if it can safely and accurately detect blood clots throughout the body using a PET-MR scan. Researchers are enrolling 165 healthy volunteers and patients with conditions like atrial fibrillation, COVID…

This study is testing if a smartwatch can help doctors better monitor patients for irregular heartbeats after heart surgery. It will compare the watch's continuous monitoring for a year against the standard method of occasional ECG check-ups. The goal is to see if the watch helps…

This study is testing if a drug called colchicine, combined with a small surgical opening in the heart's lining, can prevent a common irregular heartbeat (atrial fibrillation) after coronary bypass surgery. Researchers will compare 70 patients receiving this new approach to 70 pa…

This study aims to find out if taking blood-thinning pills can prevent strokes and other serious heart problems in people who recently had temporary atrial fibrillation (an irregular heartbeat) triggered by stress, surgery, or illness. Researchers will compare outcomes between pe…

This study is testing whether applying a special patch soaked with a heart rhythm medicine directly to the heart during surgery can prevent a common and serious complication called atrial fibrillation. The research involves 63 adults having open-heart bypass or valve surgery. Doc…

This study is testing if a heart medication called amiodarone can prevent a common and serious irregular heartbeat (atrial fibrillation) after a specific type of esophageal cancer surgery. About 90 patients will be randomly assigned to receive either the real medication or a plac…

This study is testing two different ways to stop bleeding at the leg after a heart procedure for atrial fibrillation. Researchers want to see if using a special closure device helps patients get up and walk sooner compared to the standard method of manual pressure and a stitch. T…

This study is testing a new digital toolkit, like a mobile app, designed to help people with atrial fibrillation (AFib) manage their condition. The goal is to see if using this tool improves their quality of life and reduces the burden of AFib symptoms. Researchers will compare t…

This study is testing whether specific exercise programs can help people with a long-term heart rhythm condition called atrial fibrillation feel better and improve their fitness. Researchers are comparing two types of exercise—high-intensity interval training and moderate continu…

This study aims to find out if using an electrical shock to restore a normal heart rhythm (cardioversion) actually improves how people with persistent atrial fibrillation feel day-to-day. Researchers are comparing the real procedure to a fake 'sham' procedure in 100 participants …

This study is testing if a personalized exercise program, guided by a FitBit and digital health tools, can help people with a common heart rhythm problem called atrial fibrillation (AFib) feel better. Researchers will enroll 120 adults with symptomatic AFib to see if this tech-su…

This study aims to learn if a special MRI scan that measures scarring in the heart's upper chambers can predict who will develop irregular heartbeats after heart surgery. Researchers will observe 50 patients undergoing planned heart surgery who have no history of these rhythm pro…

This study aims to understand if people with specific genetic changes and early-onset atrial fibrillation (AF) are also at risk for dangerous rapid heart rhythms from the lower heart chambers (ventricular tachycardia). Researchers will test 200 adults already scheduled for a stan…

This study is creating a registry to observe and document the real-world care of 2,000 patients who undergo heart surgery to treat atrial fibrillation (an irregular heartbeat). It aims to understand how often and why this surgery is performed, how safe and effective it is, and wh…

This study aims to use machine learning (a type of artificial intelligence) to better understand different types of atrial fibrillation (AF) and predict which ablation treatments will be successful for individual patients. Researchers will analyze detailed heart electrical data f…

This study aims to understand if certain markers in the blood related to clotting are connected to how much atrial fibrillation (AFib) a person experiences. Researchers will observe about 20 people with AFib who are scheduled for a standard catheter ablation procedure. They will …

This study aims to understand why some people with atrial fibrillation (an irregular heartbeat) still have strokes despite taking blood-thinning medication. Researchers will follow 500 patients who have had a stroke and have atrial fibrillation, collecting blood samples and heart…

This study aims to understand how common and serious irregular heartbeats are after heart surgery. Researchers will monitor 150 heart surgery patients using a wearable heart monitor patch to track heart rhythms. The goal is to identify which patients are most at risk and measure …

This study aims to identify which patients with genetic forms of early-onset atrial fibrillation are at higher risk for dangerous ventricular arrhythmias. Researchers will use specialized heart imaging and electrical mapping during scheduled procedures to look for hidden scar tis…

This study aims to understand if obstructive sleep apnea causes scarring (fibrosis) in the upper chambers of the heart. Researchers will use a special MRI scan to look for this scarring in 60 people with varying levels of sleep apnea, some with and some without a history of irreg…

This study is observing how well a small, implanted heart monitor works in everyday medical care. It will track 1,400 patients who receive the monitor to see how quickly it can detect rare, irregular heartbeats. The goal is to gather real-world information on the device's perform…

This study aims to learn more about irregular heartbeats in people with heart failure who do not have a pacemaker or defibrillator. Researchers will use a small, implanted heart monitor called the BIOMONITOR IV to track heart activity remotely for a long time. The goal is to see …

This study is watching what happens when a single heart doctor schedules eight or more procedures to implant a heart device in one day. It aims to see if doing this many procedures back-to-back is as safe and works as well as doing fewer. The results will help doctors understand …

This study aims to see if a special, non-invasive heart ultrasound scan given before surgery can predict which patients will develop dangerous irregular heartbeats (like atrial fibrillation) after heart surgery. Researchers will scan 138 patients before their operation and then m…

This study aims to compare different computer algorithms for analyzing heart scans and electrical signals in people with atrial fibrillation (an irregular heartbeat). Researchers will study data from 1,000 patients who have already undergone a standard ablation procedure. The goa…

This is a small pilot study to see if it's practical to run a larger trial on how short-term exercise affects symptoms in people with atrial fibrillation (AF). Researchers will enroll 36 symptomatic men and women with AF. Participants will try a week of moderate exercise, a week …

This research aims to learn if a simple heart rhythm test (ECG) can predict which patients are at high risk for forming dangerous blood clots that cause stroke. The study involves 1,000 people already scheduled for heart surgery. During their operation, a small piece of heart tis…

This study aims to understand why some people with beta-thalassemia develop atrial fibrillation (an irregular heart rhythm) while others don't. Researchers will compare 350 thalassemia patients with and without this heart condition to identify differences in their health data. Th…

This study aims to learn what makes a common heart rhythm procedure (ablation for atrial fibrillation) more effective and safer in everyday practice. It will follow over 1,000 patients for one year after their procedure, collecting information about their lifestyle, symptoms, and…

This study aims to better understand atrial fibrillation (AF) and predict which patients will respond best to specific heart procedures. Researchers will use heart mapping techniques on 200 patients with persistent AF who need treatment. The goal is to guide personalized therapy …

This study is collecting information on a new 3D imaging system used to guide doctors during a procedure to treat irregular heartbeats (atrial fibrillation or flutter). The system creates a detailed 3D map of the heart's upper chambers to help guide the treatment. Researchers wil…

This study aims to understand how often irregular heartbeats occur in cancer patients starting BTK inhibitor medications. Researchers will implant small heart monitors in 50 patients to continuously track their heart rhythms for up to five years. The goal is to see how frequently…